Results 41 to 50 of about 109,419 (254)

Proton Pump Inhibitors and Mucus Secretion [PDF]

Digestive Diseases and Sciences, 2009
I have read with great interest the article by Sarosiek et al. [1] reporting a stimulatory effect of rabeprazole on esophageal mucin. The article describes a pharmacological property which may have a pivotal role in protecting the esophageal mucosa against gastro-esophageal reflux and which appears to be unique in comparison with other proton pump ...
openaire   +2 more sources

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Airway mucus in infection

Frontiers in Physiology
The mucosa of the airways is under a near-constant barrage of contaminants, allergens, and pathogens that can accumulate and cause irritation or infection if not promptly removed.
Caitlin Costello, Caitlin Costello, Susan Birket, Susan Birket   +3 more
doaj   +1 more source

Perovskite Nanoparticles Toxicity Study on Airway Epithelial Cells

Nanoscale Research Letters, 2019
Research on the toxicity of nanoparticles has developed over recent years due to their increasing prevalence in common everyday materials. Various nanoparticles have been reported to promote and induce mucus secretion, which could potentially lead to ...
Shih-Ming Tsai, Maria Mesina, Tyler Goshia, Meng-Hsuen Chiu, Julia Young, Angelo Sibal, Wei-Chun Chin   +6 more
doaj   +1 more source

Activation of goblet cell Piezo1 alleviates mucus barrier damage in mice exposed to WAS by inhibiting H3K9me3 modification

Cell & Bioscience, 2023
Background Our recent studies found that intestinal mechanical signals can regulate mucus synthesis and secretion of intestinal goblet cells through piezo type mechanosensitive ion channel component 1 (Piezo1), but the detailed molecular mechanisms ...
Yan Xu, Yilin Xiong, Ying Liu, Gangping Li, Tao Bai, Gen Zheng, Xiaohua Hou, Jun Song   +7 more
doaj   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Influence of Phenylbutazone on Gastric Secretion of Mucus.

Experimental Biology and Medicine, 1967
SummaryThis study was undertaken in an attempt to clarify the mechanism by which the therapeutic use of phenylbutazone sometimes causes gastric mucosal injury in the form of hemorrhage, erosions or frank ulcerations. Mucoid secretions from gastricantral pouches of dogs were studied before, during and after the oral administration of phenylbutazone in ...
R, Menguy, L, Desbaillets
openaire   +2 more sources

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers

BMC Medical Genomics, 2012
Background Mucus hypersecretion contributes to the morbidity and mortality of smoking-related lung diseases, especially chronic obstructive pulmonary disease (COPD), which starts in the small airways.
Wang Guoqing, Xu Zhibo, Wang Rui, Al-Hijji Mohammed, Salit Jacqueline, Strulovici-Barel Yael, Tilley Ann E, Mezey Jason G, Crystal Ronald G   +8 more
doaj   +1 more source