Results 1 to 10 of about 18,381 (159)
Airway Mucus and Asthma: The Role of MUC5AC and MUC5B [PDF]
Journal of Clinical Medicine, 2017 Asthma is characterized by mucus abnormalities. Airway epithelial hyperplasia and metaplasia result in changes in stored and secreted mucin and the production of a pathologic mucus gel. Mucus transport is impaired, culminating in mucus plugging and airway obstruction—a major cause of morbidity in asthma.
Luke R Bonser, David J Erle
exaly +3 more sources
Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma
Allergology International, 2022 Background: Airway mucus hypersecretion is an important pathophysiological feature of asthma. MUC5AC and MUC5B are the major secreted polymeric mucins in airways, and their compositions affect mucus properties.
Toshiyuki Iwata +2 more
exaly +3 more sources
A SNP altering the MUC5AC mucin structure is increased in idiopathic pulmonary fibrosis together with the MUC5B SNP [PDF]
Respiratory ResearchBackground The gel-forming mucins MUC5B and MUC5AC constitute the main structural components of mucus in the respiratory system where MUC5AC is known to form nets. The MUC5B (rs35705950) Single Nucleotide Polymorphism (SNP) has been shown to increase the
Sergio Trillo-Muyo +5 more
doaj +2 more sources
Immunohistochemical detection of MUC5AC and MUC5B mucins in ferrets
BMC Research Notes, 2023 Objective Cystic fibrosis (CF) is a genetic condition that causes abnormal mucus secretions in affected organs. MUC5AC and MUC5B are gel-forming mucins and frequent targets for investigations in CF tissues.
David K. Meyerholz +8 more
doaj +3 more sources
Biochemistry and Biophysics Reports, 2019 MUC5AC is a well-known gastric differentiation marker, which has been frequently used for the classification of stomach cancer. However, the molecular mechanism of regulation of MUC5AC expression remains to be elucidated.
Natsuko Kageyama-Yahara +6 more
doaj +3 more sources
Technology in Cancer Research and Treatment, 2021 Background: Mucin 5AC (MUC5AC) belongs to the glycoprotein family of secreted gel-forming mucins and is physiologically expressed in some epithelial cells.
Franziska Büscheck +2 more
exaly +2 more sources
Muc5ac mucin expression during rat skin development
European Journal of Histochemistry, 2015 Some mucin genes have been detected during human embryonic and fetal organ development; however, little is known about mucin expression in epidermal development, neither in humans nor in other species. The present research was developed to explore Muc5ac
V. Ferretti +3 more
doaj +6 more sources
Changes in Mucin Production in Human Airway Epithelial Cells After Exposure to Electronic Cigarette Vapor With or Without Nicotine [PDF]
Clinical and Experimental Otorhinolaryngology, 2021 Objectives The emergence of electronic cigarettes (e-cigarettes) has created new perceptions of the tobacco market. Unlike traditional tobacco, the greatest advantage of e-cigarettes is that they have less smell and are convenient and inexpensive. Most e-
Si-Youn Song +5 more
doaj +1 more source
The effect of 8 weeks of quercetin supplementation and intermittent exercise on gene expression of Muc5Ac, Muc4 and polyphosphate in rats with colon cancer [PDF]
Sport Sciences and Health Research, 2023 Background: Expression of mucosal levels would affect the function of internal organs of the body and the digestive system, such as by creating a blockage for the progression of cancerous tumors and the failure of the target tissue, especially the large ...
Shahin Heydari +2 more
doaj +1 more source
ROMO1 is involved in airway mucus hypersecretion in COPD through the mitochondrial ROS-STAT6 pathway [PDF]
Respiratory ResearchBackground Oxidative stress contributes to airway mucus hypersecretion in the pathogenesis of chronic obstructive pulmonary disease (COPD). Although reactive oxygen species modulator 1 (ROMO1) is involved in mitochondrial oxidative stress, its role in ...
Shaobo Ge +9 more
doaj +2 more sources