Results 31 to 40 of about 21,687 (212)

Epithelial Aryl Hydrocarbon Receptor Protects From Mucus Production by Inhibiting ROS-Triggered NLRP3 Inflammasome in Asthma

Frontiers in Immunology, 2021
BackgroundDespite long-standing recognition in the significance of mucus overproduction in asthma, its etiology remains poorly understood. Muc5ac is a secretory mucin that has been associated with reduced pulmonary function and asthma exacerbations ...
Xinyue Hu, Xinyue Hu, Yingchun Shen, Yilin Zhao, Ji Wang, Ji Wang, Ji Wang, Xin Zhang, Xin Zhang, Wei Tu, Wei Tu, William Kaufman, Juntao Feng, Peisong Gao   +13 more
doaj   +1 more source

Exploiting the MUC5AC Antigen for Noninvasive Identification of Pancreatic Cancer [PDF]

Journal of Nuclear Medicine, 2021
Pancreatic cancer (PC) remains the fourth leading cause of cancer death; therefore, there is a clinically unmet need for novel therapeutics and diagnostic markers to treat this devastating disease. Physicians often rely on biopsy or CT for diagnosis, but more specific protein biomarkers are highly desired to assess the stage and severity of PC in a ...
Kelly E, Henry, Travis M, Shaffer, Kyeara N, Mack, Janine, Ring, Anuja, Ogirala, Susanne, Klein-Scory, Christina, Eilert-Micus, Wolff, Schmiegel, Thilo, Bracht, Barbara, Sitek, Marguerite, Clyne, Colm J, Reid, Bence, Sipos, Jason S, Lewis, Holger, Kalthoff, Jan, Grimm   +15 more
openaire   +2 more sources

PTPRH Alleviates Airway Obstruction and Th2 Inflammation in Asthma as a Protective Factor

Journal of Asthma and Allergy, 2022
Feng-jia Chen,1,2,* Li-juan Du,1,2,* Zhimin Zeng,1,2,* Xin-yan Huang,1,2 Chang-yi Xu,1,2 Wei-ping Tan,1,2 Can-mao Xie,1,2 Yu-xia Liang,1,2 Yu-biao Guo1,2 1Division of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun ...
Chen F, Du L, Zeng Z, Huang X, Xu C, Tan W, Xie C, Liang Y, Guo Y   +8 more
doaj  

Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease

The Journal of Clinical Investigation, 2022
The respiratory tract surface is protected from inhaled pathogens by a secreted layer of mucus rich in mucin glycoproteins. Abnormal mucus accumulation is a cardinal feature of chronic respiratory diseases, but the relationship between mucus and ...
Aran Singanayagam, Joseph Footitt, Matthias Marczynski, Giorgia Radicioni, Michael T. Cross, Lydia J. Finney, Maria-Belen Trujillo-Torralbo, Maria Calderazzo, Jie Zhu, Julia Aniscenko, Thomas B. Clarke, Philip L. Molyneaux, Nathan W. Bartlett, Miriam F. Moffatt, William O. Cookson, Jadwiga Wedzicha, Christopher M. Evans, Richard C. Boucher, Mehmet Kesimer, Oliver Lieleg, Patrick Mallia, Sebastian L. Johnston   +21 more
doaj   +1 more source

Effect of Tobacco-specific Nitrosamines on MUC5AC Expression in Human Airway Epithelial Cells [PDF]

Journal of Rhinology, 2020
Background and Objectives Nicotine is oxidized into tobacco-specific nitrosamines (TSNAs; NAB, NAT, NNN, NNAL, NNK) at high temperature and high pressure.
Soyoung Kwak, Yoon Seok Choi, Hyung Gyun Na, Chang Hoon Bae, Si-Youn Song, Yong-Dae Kim   +5 more
doaj   +1 more source

Human iPSC-Derived Vascularised Lung Organoids for Modelling COPD and Pulmonary Hypertension. [PDF]

Cell Prolif
Vascularised lung organoids (vLOs) that faithfully mimic human lung tissue architecture and disease pathology are critical for advancing pulmonary research but remain challenging to generate. Here, we developed a robust self‐organisation protocol to produce vLOs with cellular heterogeneity and functional vasculature. The engineered blood vessels within
Jiang S, Tian L, Qu J, Hong Y, Chen D, Pan Z, Long H, Chu L, Kong W, Yao Q, Ma X, Zhao Y, Ma B, Wang K, Chen Y.   +14 more
europepmc   +2 more sources

CREB mediates prostaglandin F2alpha-induced MUC5AC overexpression [PDF]

, 2009
Mucus secretion is an important protective mechanism for the luminal lining of open tubular organs, but mucin overproduction in the respiratory tract can exacerbate the inflammatory process and cause airway obstruction.
Zeldin, Darryl C, Koo, Ja Seok, Chung, Wen-Cheng, Ryu, Seung-Hee, Sun, Hongxia   +4 more
core   +1 more source

An animal study on the effect of topically administered ambroxol for dry eye

Frontiers in Bioscience-Landmark, 2022
Objective: To evaluate the effect of 0.2% ambroxol eye drop on tear secretion and corneal healing on a rabbit dry eye model, and to delineate potential underlying mechanisms.
Zixuan Wang, Li Yu, Shaochong Zhang, Zhenhan Wang, Mingwu Wang   +4 more
doaj   +1 more source

C-Mannosylation of MUC5AC and MUC5B Cys subdomains [PDF]

Glycobiology, 2004
We expressed recombinant Cys subdomains in COS-7 cells to examine the role of this highly conserved protein domain in mucin biosynthesis. The entire Cys1 and Cys5 and Cys1 and Cys3 subdomains in MUC5AC and MUC5B, respectively, each with six carboxyl terminal histidine residues, were pulse-labeled with [(35)S]cysteine/methionine, and the labeled ...
Juan, Perez-Vilar, Scott H, Randell, Richard C, Boucher   +2 more
openaire   +2 more sources

The biochemical and molecular characterisation of respiratory mucins in TB [PDF]

, 2006
Includes bibliographical references (leaves 96-112).The role of the dominant respiratory mucins (MUC5AC and MUC5B) and MUC2 has been investigated in chronic airway diseases as it is the mucin glycoprotein that confers upon mucus its biological ...
Govender, Ureshnie
core   +1 more source