Results 21 to 30 of about 21,687 (212)

Dissecting the MUC5AC/ANXA2 signaling axis: implications for brain metastasis in lung adenocarcinoma

Experimental and Molecular Medicine
Non-small cell lung carcinoma (NSCLC) exhibits a heightened propensity for brain metastasis, posing a significant clinical challenge. Mucin 5ac (MUC5AC) plays a pivotal role in the development of lung adenocarcinoma (LUAD); however, its role in causing ...
Sanjib Chaudhary, Jawed Akhtar Siddiqui, Muthamil Iniyan Appadurai, Shailendra Kumar Maurya, Swathi P. Murakonda, Elizabeth Blowers, Ben J. Swanson, Mohd Wasim Nasser, Surinder K. Batra, Imayavaramban Lakshmanan, Apar Kishor Ganti   +10 more
doaj   +2 more sources

Long-Term Ocular Outcomes of Dupilumab in Atopic Dermatitis: Results From the BioDay Registry. [PDF]

Clin Transl Allergy
ABSTRACT Background Dupilumab‐associated ocular surface disease (DAOSD) is the most reported side effect in dupilumab‐treated atopic dermatitis (AD) patients. We investigated the effect of long‐term dupilumab treatment on ocular surface disease (OSD), conjunctival goblet cells (GCs), and tear fluid dupilumab levels and proteins.
Veldhuis N, Achten RE, van Luijk CM, van der Wal MM, den Hartog Jager CF, Zuithoff NPA, El Amrani M, Knol EF, van Wijk F, de Graaf M, Haeck IM, Dickman MM, de Bruin-Weller MS.   +12 more
europepmc   +2 more sources

Benzo(a)pyrene induces MUC5AC expression through the AhR/mitochondrial ROS/ERK pathway in airway epithelial cells

Ecotoxicology and Environmental Safety, 2021
Objectives: Benzo(a)pyrene (BaP) is a ubiquitous air pollutants, and BaP exposure leads to a risk of respiratory diseases. The oversecretion of airway mucus and high expression of mucin 5AC (MUC5AC) are associated with common respiratory disorders caused
Yipeng Sun, Zhaowen Shi, Yuhua Lin, Mengzhe Zhang, Jinjin Liu, Linyun Zhu, Qingge Chen, Junjie Bi, Shanqun Li, Zhenhua Ni, Xiongbiao Wang   +10 more
doaj   +1 more source

Effects of baicalin on expression of mucin 5AC and cystic fibrosis transmembrane conductance regulator in airway epithelium through NF-κB signaling pathway

Di-san junyi daxue xuebao, 2022
Objective To investigate the mechanism of baicalin in improving pathological airway mucus by regulating the expression of airway epithelial mucus regulators mucin 5AC (MUC5AC) and cystic fibrosis transmembrane conductance regulator (CFTR) through nuclear
ZHANG Yan, ZHANG Caili, LIU Yan, CHEN Yulong, PENG , SANG Yazhou, WU Yaosong, WU Yaosong, WU Yaosong   +8 more
doaj   +1 more source

Differential Regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 Expression in Airway Epithelium [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2005
Abstract This study demonstrates that the two biomarkers, MUC5AC/ Muc5ac and hCLCA1/Gob5, which are frequently associated with surface mucous/goblet cells in asthmatic airways, are differentially regulated. Intratracheal instillation of IL-13 (0.5 μg/mouse lung) elicited 8- and 110-fold induction of Muc5ac and Gob5 messages ...
Philip, Thai, Yin, Chen, Gregory, Dolganov, Reen, Wu   +3 more
openaire   +2 more sources

Associations between the expression of mucins (MUC1, MUC2, MUC5AC and MUC6) and clinicopathologic parameters of human breast carcinomas

Indian Journal of Pathology and Microbiology, 2020
Aims: The aim of this study is to evaluate the relationships between the expression of mucins in invasive breast carcinomas and clinicopathologic parameters.
Onur Oral, Hatice Unverdi, Emrah Kumcu, Duygu Turkbey, Serdar Dogan, Sema Hucumenoglu   +5 more
doaj   +1 more source

Ghrelin Downregulates Lipopolysaccharide/ Leptin-Induced MUC5AC Expression in Human Nasal Epithelial Cells [PDF]

Clinical and Experimental Otorhinolaryngology, 2023
Objectives. Obesity, which induces chronic low-grade systemic inflammation in the human body, is a known risk factor for various diseases. Recent studies have shown associations between various otorhinolaryngological diseases and obesity.
Yoon Seok Choi, Hyung Gyun Na, Chang Hoon Bae, Si-Youn Song, Yong-Dae Kim   +4 more
doaj   +1 more source

A Rheological Study of the Association and Dynamics of MUC5AC Gels [PDF]

Biomacromolecules, 2017
The details of how a mucus hydrogel forms from its primary structural component, mucin polymers, remain incompletely resolved. To explore this, we use a combination of macrorheology and single-particle tracking to investigate the bulk and microscopic mechanical properties of reconstituted MUC5AC mucin gels. We find that analyses of thermal fluctuations
Caroline E. Wagner, Bradley S. Turner, Michael Rubinstein, Gareth H. McKinley, Katharina Ribbeck   +4 more
openaire   +4 more sources

Role of MUC5AC in the pathogenesis of exercise-induced bronchoconstriction [PDF]

Journal of Allergy and Clinical Immunology, 2007
The pathogenesis of exercise-induced bronchoconstriction (EIB) involves the release of mediators from several airway cells in response to exercise challenge, but the mechanism leading to airflow obstruction during EIB is incompletely understood.To evaluate the role of secreted mucin in the pathogenesis of EIB.Induced sputum was collected at baseline ...
Teal S, Hallstrand, Jason S, Debley, Federico M, Farin, William R, Henderson   +3 more
openaire   +2 more sources

Integrin β1 subunit regulates cellular and secreted MUC5AC and MUC5B production in NCI–H292 human lung epithelial cells

Biochemistry and Biophysics Reports, 2021
The surface of the human respiratory tract is covered with a mucus layer containing mucin 5AC (MUC5AC) and mucin 5B (MUC5B) as the main components. This layer contributes to biological defense by eliminating irritants, but excessive MUC5AC secretion by ...
Jun Iwashita, Jun Murata
doaj   +1 more source