Results 41 to 50 of about 21,687 (212)

Type IV collagen reduces mucin 5AC secretion in three-dimensional cultured human primary airway epithelial cells

Biochemistry and Biophysics Reports, 2019
Mucin 5AC (MUC5AC) hypersecretion induces airway narrowing in patients with asthma, which leads to breathing problems. We investigated the regulation of MUC5AC secretion by extracellular matrix (ECM) proteins in human primary airway epithelial cells from
Yuho Ito, Jun Iwashita, Jun Murata
doaj   +1 more source

Serum MUC5AC protein levels are correlated with the development and severity of connective tissue disease-associated pulmonary interstitial lesions

Frontiers in Immunology, 2022
BackgroundMucin 5AC (MUC5AC) and mucin 5B (MUC5B) are the major components of airway mucins. The expression levels of MUC5AC and MUC5B are related to connective tissue disease-associated interstitial lung disease (CTD-ILD) in the promoter region of ...
Lin Weng, Wei Liu, Lingye Wang, Zhichao Wu, Dehao Liu, Yihua Lin, Shuli Song, Ciyuan Yu, Yaqiong Chen, Juan Chen, Shengxiang Ge   +10 more
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Evaluation of mucin changes between daily and extended wear silicone hydrogel contact lenses

African Vision and Eye Health
Background: Initially, contact lenses were recommended only for daily wear because of infection and discomfort concerns. With rising demand, particularly for overnight use, extended wear lenses have gained significance.
Rio Rhendy, Tri Rahayu, Lukman Edwar, Mohamad Sadikin, Aria Kekalih   +4 more
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SIRT3 knockout aggravates LPS-induced eustachian tube dysfunction

Journal of Otology
PurposeAcute otitis media caused by gram-negative bacteria is a common otological condition among pediatric patients. Eustachian tube dysfunction (ETD) plays a pivotal role in the delayed resolution of acute otitis media, whereas the precise contribution
Shimin Zong, Huimin Zhang, Ting Li, Xi Lian, Wei Tang, Tianyi Liu, Wenting Yu, Xuan Yu, Hongjun Xiao   +8 more
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Suppression of MUC5AC expression in human bronchial epithelial cells by interferon-γ

Allergology International, 2017
Background: Excessive mucin secretion in the airway is an important feature of airway inflammatory diseases. MUC5AC expression is regulated by a variety of stimuli such as cytokines.
Takahito Oyanagi, Takumi Takizawa, Akira Aizawa, Orosoo Solongo, Hisako Yagi, Yutaka Nishida, Harumi Koyama, Akihiko Saitoh, Hirokazu Arakawa   +8 more
doaj   +1 more source

Type IV collagen reduces MUC5AC secretion in the lungs of ovalbumin-sensitized mice

Frontiers in Pharmacology, 2022
Mucin 5AC (MUC5AC) is excessively secreted in the respiratory tract of patients with asthma. Suppressing this secretion is important for improving the air passages, which facilitates easy breathing.
Jun Iwashita, Hikari Maeda, Momo Ishimura, Jun Murata   +3 more
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CD147 increases mucus secretion induced by cigarette smoke in COPD

BMC Pulmonary Medicine, 2019
Background CD147 is expressed in many tissues and is involved in many inflammatory diseases. Emerging evidence suggests that the overproduction of mucus is a malignant factor in chronic obstructive pulmonary disease (COPD), which results in severe airway
Qiao Yu, Danhui Yang, Xi Chen, Qiong Chen   +3 more
doaj   +1 more source

Neutrophil elastase stimulates MUC5AC expression in human biliary epithelial cells: a possible pathway of PKC/Nox/ROS

, 2017
Introduction : Bacterial infection and bile flow retardation form a vicious cycle which promotes stone formation and recurrence, and it seems that mucin overexpression plays an important role in this process.
Shuodong Wu, Min Li, Ben Sun, Duoliang Wang, Yu Tian, Hong Wang, Junqing Xie   +6 more
core   +1 more source

Hypoxia-mediated mechanism of MUC5AC production in human nasal epithelia and its implication in rhinosinusitis. [PDF]

PLoS ONE, 2014
Excessive mucus production is typical in various upper airway diseases. In sinusitis, the expression of MUC5AC, a major respiratory mucin gene, increases.
Yoon-Ju Kim, Hyung-Ju Cho, Woo-Chul Shin, Hyun-Ah Song, Joo-Heon Yoon, Chang-Hoon Kim   +5 more
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RNA interference suppression of mucin 5AC (MUC5AC) reduces the adhesive and invasive capacity of human pancreatic cancer cells

Journal of Experimental & Clinical Cancer Research, 2010
Background MUC5AC is a secretory mucin normally expressed in the surface muconous cells of stomach and bronchial tract. It has been known that MUC5AC de novo expression occurred in the invasive ductal carcinoma and pancreatic intraepithelial neoplasm ...
Yamada Nobuya, Amano Ryosuke, Sawada Tetsuji, Tanaka Hiroaki, Yamazoe Sadaaki, Ohira Masaichi, Hirakawa Kosei   +6 more
doaj   +1 more source