Results 51 to 60 of about 21,687 (212)

Muc5ac Expression Protects the Colonic Barrier in Experimental Colitis [PDF]

Inflammatory Bowel Diseases, 2020
Abstract Background The mucus gel layer (MGL) lining the colon is integral to exclusion of bacteria and maintaining intestinal homeostasis in health and disease. Some MGL defects allowing bacteria to directly contact the colonic surface are commonly observed in ulcerative colitis (UC).
Kristine E Olli, Caroline Rapp, Lauren O’Connell, Colm B Collins, Eoin N McNamee, Owen Jensen, Paul Jedlicka, Kristen C Allison, Matthew S Goldberg, Mark E Gerich, Daniel N Frank, Diana Ir, Charles E Robertson, Christopher M Evans, Carol M Aherne   +14 more
openaire   +4 more sources

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

M1/MUC5AC mucin released by human airways in vitro [PDF]

European Respiratory Journal, 1999
A series of monoclonal antibodies which bind to a mucin known as M1 (anti-M1 MAbs) have also been shown to detect the product of the human gene MUC5AC. The aim of this investigation was to determine the concentration of the M1 mucin in the surface epithelium of human bronchial preparations by means of immunohistochemistry and in the bronchial fluid ...
C, Labat, J, Bara, J P, Gascard, H, Sossé-Alaoui, V, Thomas de Montpreville, M, Yeadon, C, Brink   +6 more
openaire   +2 more sources

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Gene expression of SPDEF & MUC5AC mRNA and ELISA for MUC5AC mucin secretion.

, 2014
A - Gene expression of SPDEF mRNA using comparative quantitation real time PCR in IL-13 stimulated PNECs and PBECs expressed as fold change compared to unstimulated cells.
Jeremy C. Parker (411704), Michael D Shields (514966), Michael E. McBrien (514965), Liam G. Heaney (411708), Grzegorz Skibinski (411706), Surendran Thavagnanam (411705)   +5 more
core   +1 more source

Sputum MUC5AC and MUC5B pQTL.

, 2023
Hyper-secretion and/or hyper-concentration of mucus is a defining feature of multiple obstructive lung diseases, including chronic obstructive pulmonary disease (COPD). Mucus itself is composed of a mixture of water, ions, salt and proteins, of which the
Suresh Garudadri (10682665), Stephanie A. Christenson (2993706), Mehmet Kesimer (800987), Sarah Lester (8830154), Maarten van den Berge (116456), Victor E. Ortega (7782260), Wanda K. O’Neal (2993700), Jerry A. Krishnan (7923323), Jeffrey L. Curtis (10682674), MeiLan K. Han (2616532), Tuuli Lappalainen (95615), Michael H. Cho (6856079), Yun Li (692280), Silva Kasela (817613), Eric Van Buren (14920593), Annette Hastie (16437842), Samir N. P. Kelada (6666578), Hong Dang (2090011), Emily S. Wan (7512374), Martijn C. Nawijn (11188479), Giorgia Radicioni (800990), Edwin K. Silverman (6856082)   +21 more
core   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Secretory Mucin MUC5AC in Gastrointestinal Malignancies [PDF]

, 2016
Secretory mucin MUC5AC is an extensively glycosylated high molecular weight protein that forms a polymeric gel layer over the epithelial layers under physiological conditions, to protect these surfaces from myriad of insults.
Krishn, Shiv Ram
core  

Fluorescent Anti-MUC5AC Brightly Targets Pancreatic Cancer in a Patient-derived Orthotopic Xenograft [PDF]

, 2022
BackgroundOverexpression of mucin-5AC (MUC5AC) makes it a targetable biomarker in pancreatic cancer. The present study evaluated tumor targeting with a MUC5AC antibody conjugated to a near-infrared dye in a patient-derived orthotopic xenograft (PDOX ...
THINZAR M. LWIN, Turner, Michael A, ROBERT M. HOFFMAN, SURINDER K. BATRA, Lowy, Andrew M, Kaur, Sukhwinder, Amirfakhri, Siamak, Natarajan, Gopalakrishnan, SUKHWINDER KAUR, MICHAEL BOUVET, Batra, Surinder K, GOPALAKRISHNAN NATARAJAN, HIROTO NISHINO, Bouvet, Michael, KAVITA MALLYA, SIAMAK AMIRFAKHRI, Nishino, Hiroto, ANDREW M. LOWY, Mallya, Kavita, Hollandsworth, Hannah M, Lwin, Thinzar M, Hoffman, Robert M, MICHAEL A. TURNER, HANNAH M. HOLLANDSWORTH   +23 more
core   +1 more source

A General High‐Throughput Mucus Microrheology Platform for Quantitative and Scalable Mucus Phenotyping

Advanced Science, EarlyView.
High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling, Ayşe Tuğçe Şahin, Bernardo Miller Naranjo, Stefano Aime, Doris Roth, Anna Pukaluk, Niels Tepho, Romina Augustin, Benedetta Zampa, Andrea S. Vendrame, Mark‐Christian Klassen, Ellen Emken, Marion Kiechle, Mircea Gabriel Stoleriu, Pontus Mertsch, Ruth Olmer, Yohannes Tesfaigzi, Oliver Lieleg, Janna C. Nawroth   +18 more
wiley   +1 more source