Results 41 to 50 of about 6,153 (212)
Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity. [PDF]
, 2019 TMEM16F is activated by elevated intracellular Ca2+, and functions as a small-conductance ion channel and as a phospholipid scramblase. In contrast to its paralogs, the TMEM16A/B calcium-activated chloride channels, mouse TMEM16F has been reported as a ...
Han, Tina W +4 more
core +2 more sources
Frontiers in Physiology, 2022 Background: Cardiac hypertrophy (CH) occurs with an increase in myocardium mass as an adaptive compensation to increased stress. Prolonged CH causes decompensated heart failure (HF).
Yaofang Zhang +4 more
doaj +1 more source
TMEM16A chloride channel does not drive mucus production
Life Science Alliance, 2019 Despite being essential for airway hydration, TMEM16A is not required for mucus (MUC5AC) production. Cell proliferation is the main driver for TMEM16A up-regulation during inflammation.
Filipa B Simões +7 more
doaj +1 more source
Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer
Molecular Cancer, 2017 TMEM16A (known as anoctamin 1) Ca2+-activated chloride channel is overexpressed in many tumors. TMEM16A overexpression can be caused by gene amplification in many tumors harboring 11q13 amplification.
Hui Wang +6 more
doaj +1 more source
Gating the pore of the calcium-activated chloride channel TMEM16A [PDF]
Nature Communications, 2021 AbstractThe binding of cytoplasmic Ca2+ to the anion-selective channel TMEM16A triggers a conformational change around its binding site that is coupled to the release of a gate at the constricted neck of an hourglass-shaped pore. By combining mutagenesis, electrophysiology, and cryo-electron microscopy, we identified three hydrophobic residues at the ...
Lam, Andy K M +3 more
openaire +4 more sources
The extracellular calcium-sensing receptor regulates human fetal lung development via CFTR [PDF]
, 2016 Optimal fetal lung growth requires anion-driven fluid secretion into the lumen of the developing organ. The fetus is hypercalcemic compared to the mother and here we show that in the developing human lung this hypercalcaemia acts on the extracellular ...
Brennan, Sarah C. +10 more
core +2 more sources
Control of Ion Transport by Tmem16a Expressed in Murine Intestine
Frontiers in Physiology, 2019 Cl– secretion by the human and murine intestinal epithelium occurs through the cystic fibrosis transmembrane conductance regulator (cftr). However, the Ca2+ activated Cl– channel Tmem16a was shown to contribute to Cl– secretion, mainly, but not ...
Karl Kunzelmann +8 more
doaj +1 more source
TMEM16A as a potential treatment target for head and neck cancer
Journal of Experimental & Clinical Cancer Research, 2022 Transmembrane protein 16A (TMEM16A) forms a plasma membrane-localized Ca2+-activated Cl- channel. Its gene has been mapped to an area on chromosome 11q13, which is amplified in head and neck squamous cell carcinoma (HNSCC).
Kohei Okuyama, Souichi Yanamoto
doaj +1 more source
Frontiers in Pharmacology, 2021 Background: Effective anticancer therapy can be achieved by identifying novel tumor-specific drug targets and screening of new drugs. Recently, TMEM16A has been identified to be overexpressed in lung adenocarcinoma, and inhibitors of TMEM16A showed ...
Shuai Guo +9 more
doaj +1 more source
Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. [PDF]
, 2019 As a Ca2+-activated lipid scramblase and ion channel that mediates Ca2+ influx, TMEM16F relies on both functions to facilitate extracellular vesicle generation, blood coagulation, and bone formation.
Cheng, Tong +9 more
core +1 more source