Results 41 to 50 of about 6,139 (238)

Co-targeting TMEM16A with a novel monoclonal antibody and EGFR with Cetuximab inhibits the growth and metastasis of esophageal squamous cell carcinoma

Journal of Translational Medicine
The chloride channel transmembrane protein 16A (TMEM16A) possesses a calcium-activated property linked to tumor-promoting malignant phenotype and electrophysiological stability.
Yutian Zheng, Lin Meng, Like Qu, Chuanke Zhao, Lixin Wang, Jiayi Ma, Caiyun Liu, Chengchao Shou   +7 more
doaj   +2 more sources

TMEM16A Antagonism: Therapeutic Potential with Desensitization of β-Agonist Responsiveness in Asthma. [PDF]

Am J Respir Cell Mol Biol
The efficacy of β-agonists in asthma is severely limited by β-adrenoceptor desensitization which results in poorly managed symptoms and refractory bronchoconstriction.
Wu A, Kuforiji A, Zhang Y, Xu D, Perez-Zoghbi J, Emala C, Danielsson J.   +6 more
europepmc   +2 more sources

HIF‐Regulated Pannexin‐1 Channel Drives Luminal ATP Accumulation in Kidney Cysts [PDF]

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Kathrin Skoczynski, Julia Katharina Scholz, Raluca Ursu, Johannes Schödel, Steffen Grampp, Stephanie Naas, Victoria Lauer, Mario Schiffer, Maike Büttner‐Herold, Bjoern Buchholz, Andre Kraus   +10 more
wiley   +2 more sources

Niclosamide potentiates TMEM16A and induces vasoconstriction

Biophysical Journal, 2023
Niclosamide, a proposed TMEM16A inhibitor for asthma and COPD, unexpectedly enhances TMEM16A activity, raising caution for its clinical use. Discovering its binding site on TMEM16A aids in developing targeted modulators for various diseases.
P. Liang, Y. Wan, Kuai Yu, H. Hartzell, Huang-He Yang   +4 more
semanticscholar   +4 more sources

Regulation of TMEM16A altrenatice splincing

, 2012
TMEM16A/Anoctamin1 is a novel calcium-­‐activated chloride channel involved in neuronal and cardiac excitation, vascular tone, pain perception and olfactory and sensory signal transduction and GI tract motility.
Ubby, Ifeoma
core   +2 more sources

The Tmem16a chloride channel is required for mucin maturation after secretion from goblet-like cells in the Xenopus tropicalis tadpole skin

Scientific Reports
The TMEM16A chloride channel is proposed as a therapeutic target in cystic fibrosis, where activation of this ion channel might restore airway surface hydration and mitigate respiratory symptoms.
Eamon Dubaissi, Emma N. Hilton, Sarah Lilley, Richard Collins, Charlotte Holt, Peter March, Henry Danahay, Martin Gosling, Richard K Grencis, Ian S Roberts, David J Thornton   +10 more
doaj   +2 more sources

Ca2+-activated Cl− channel TMEM16A inhibition by cholesterol promotes angiogenesis in endothelial cells

Journal of Advanced Research, 2021
Introduction: Ca2+-activated Cl− channel TMEM16A is expressed in endothelial cells, and contributes to many diseases such as hypertension, blood-brain barrier dysfunction, and pulmonary hypertension.
Ke Ma, Sitong Liu, Hongyue Liang, Guan Wang, Tianyu Wang, Shuya Luo, Kuan Gao, Hui Wang, Mei Liu, Lichuan Bai, Qinghuan Xiao   +10 more
doaj   +1 more source

A Pharmacological Investigation of the TMEM16A Currents in Murine Skeletal Myogenic Precursor Cells [PDF]

International Journal of Molecular Sciences
TMEM16A is a Ca2+-activated Cl− channel expressed in various species and tissues. In mammalian skeletal muscle precursors, the activity of these channels is still poorly investigated.
M. Sciancalepore, Asja Ragnini, Paola Zacchi, V. Borelli, Paola D'Andrea, P. Lorenzon, A. Bernareggi   +6 more
semanticscholar   +2 more sources

Activation of TMEM16A Ca2+-activated Cl− channels by ROCK1/moesin promotes breast cancer metastasis

Journal of Advanced Research, 2021
Introduction: Transmembrane protein 16A (TMEM16A) is a Ca2+-activated chloride channel that plays a role in cancer cell proliferation, migration, invasion, and metastasis.
Shuya Luo, Hui Wang, Lichuan Bai, Yiwen Chen, Si Chen, Kuan Gao, Huijie Wang, Shuwei Wu, Hanbin Song, Ke Ma, Mei Liu, Fan Yao, Yue Fang, Qinghuan Xiao   +13 more
doaj   +1 more source

Expression of TMEM16A in Colorectal Cancer and Its Correlation With Clinical and Pathological Parameters

Frontiers in Oncology, 2021
TMEM16A is a recently identified calcium-activated chloride channel (CaCC) and its overexpression contributes to tumorigenesis and progression in several human malignancies.
Hongxia Li, Qiwei Yang, Sibo Huo, Sibo Huo, Zhenwu Du, Zhenwu Du, Fei Wu, Haiyue Zhao, Shifan Chen, Longfei Yang, Zhiming Ma, Yujie Sui   +11 more
doaj   +1 more source