Results 41 to 50 of about 3,802 (167)
Acta Pharmaceutica Sinica B, 2021 Vascular smooth muscle cell (VSMC) migration plays a critical role in the pathogenesis of many cardiovascular diseases. We recently showed that TMEM16A is involved in hypertension-induced cerebrovascular remodeling.
Huaqing Zheng +10 more
doaj +1 more source
PLoS ONE, 2015 TMEM16A, a calcium-activated chloride channel (CaCC), is highly amplified and expressed in human cancers and is involved in the growth and metastasis of some malignancies. Inhibition of TMEM16A represents a novel pharmaceutical approach for the treatment
Yujie Sui +11 more
doaj +1 more source
Expression of TMEM16A and SLC4A4 in Human Pancreatic Islets [PDF]
Cellular Physiology and Biochemistry, 2012 Stimulation of insulin release by D-glucose is accompanied by Cl(-) and HCO(3)(-) efflux from pancreatic islet cells. The efflux of these anions may involve volume-regulated anion channels, including possibly TMEM16A, and the Na(+)-HCO(3)(-)-cotransporter SLC4A4.
Hanzu, Felicia A +7 more
openaire +3 more sources
Frontiers in Physiology, 2022 Background: Cardiac hypertrophy (CH) occurs with an increase in myocardium mass as an adaptive compensation to increased stress. Prolonged CH causes decompensated heart failure (HF).
Yaofang Zhang +4 more
doaj +1 more source
TMEM16A chloride channel does not drive mucus production
Life Science Alliance, 2019 Despite being essential for airway hydration, TMEM16A is not required for mucus (MUC5AC) production. Cell proliferation is the main driver for TMEM16A up-regulation during inflammation.
Filipa B Simões +7 more
doaj +1 more source
Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer
Molecular Cancer, 2017 TMEM16A (known as anoctamin 1) Ca2+-activated chloride channel is overexpressed in many tumors. TMEM16A overexpression can be caused by gene amplification in many tumors harboring 11q13 amplification.
Hui Wang +6 more
doaj +1 more source
Epithelial Chloride Transport by CFTR Requires TMEM16A [PDF]
Scientific Reports, 2017 AbstractCystic Fibrosis Transmembrane Conductance Regulator (CFTR) is the secretory chloride/bicarbonate channel in airways and intestine that is activated through ATP binding and phosphorylation by protein kinase A, but fails to operate in cystic fibrosis (CF).
Roberta Benedetto +8 more
openaire +3 more sources
ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC) [PDF]
Pflügers Archiv - European Journal of Physiology, 2014 Pancreatic ductal adenocarcinoma (PDAC) has one of the worst survival rates of all cancers. ANO1 (TMEM16A) is a recently identified Ca(2+)-activated Cl(-) channel (CaCC) that is upregulated in several tumors. Although ANO1 was subject to extensive studies in the recent years, its pathophysiological function has only been poorly understood.
Sauter, Daniel Rafael Peter +4 more
openaire +4 more sources
TMEM16A as a potential treatment target for head and neck cancer
Journal of Experimental & Clinical Cancer Research, 2022 Transmembrane protein 16A (TMEM16A) forms a plasma membrane-localized Ca2+-activated Cl- channel. Its gene has been mapped to an area on chromosome 11q13, which is amplified in head and neck squamous cell carcinoma (HNSCC).
Kohei Okuyama, Souichi Yanamoto
doaj +1 more source
Frontiers in Pharmacology, 2021 Background: Effective anticancer therapy can be achieved by identifying novel tumor-specific drug targets and screening of new drugs. Recently, TMEM16A has been identified to be overexpressed in lung adenocarcinoma, and inhibitors of TMEM16A showed ...
Shuai Guo +9 more
doaj +1 more source