Results 61 to 70 of about 6,153 (212)

Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing [PDF]

Journal of Biological Chemistry, 2009
Expression of TMEM16A protein is associated with the activity of Ca(2+)-activated Cl(-) channels. TMEM16A primary transcript undergoes alternative splicing. thus resulting in the generation of multiple isoforms. We have determined the pattern of splicing and assessed the functional properties of the corresponding TMEM16A variants.
Ferrera, Loretta, Caputo, Antonella, Ubby, Ifeoma, Bussani, Erica, Zegarra-Moran, Olga, Ravazzolo, Roberto, Pagani, Franco, Galietta, Luis J. V.   +7 more
openaire   +4 more sources

Calcium- and Voltage-Dependent Dual Gating ANO1 is an Intrinsic Determinant of Repolarization in Rod Bipolar Cells of the Mouse Retina

Cells, 2020
TMEM16A/anoctamin1 (ANO1), a calcium (Ca2+)-activated chloride (Cl−) channel, has many functions in various excitable cells and modulates excitability in both Ca2+- and voltage-gating modes.
Sun-Sook Paik, Yong Soo Park, In-Beom Kim   +2 more
doaj   +1 more source

Intestinal TMEM16A control luminal chloride secretion in a NHERF1 dependent manner

Biochemistry and Biophysics Reports, 2021
TMEM16A (Transmembrane protein 16A or Anoctamin1) is a calcium-activated chloride channel.(CaCC),that exerts critical roles in epithelial secretion. However, its localization, function, and regulation in intestinal chloride (Cl−) secretion remain obscure.
Tultul Saha, Joydeep Aoun, Mikio Hayashi, Sheikh Irshad Ali, Paramita Sarkar, Prasanta Kumar Bag, Normand Leblanc, Nadia Ameen, Owen M. Woodward, Kazi Mirajul Hoque   +9 more
doaj   +1 more source

Genetic disruption of Ano5 in mice does not recapitulate human ANO5-deficient muscular dystrophy [PDF]

, 2015
BACKGROUND: Anoctamin 5 (ANO5) is a member of a conserved gene family (TMEM16), which codes for proteins predicted to have eight transmembrane domains and putative Ca(2+)-activated chloride channel (CaCC) activity. It was recently reported that mutations
Jing Xu, Kyle Floyd, Li Xu, Lixia Zhao, Mona El Refaey, Paul M. L. Janssen, Renzhi Han, Tallib Karaze, Yandi Gao   +8 more
core   +1 more source

Increased complexity of Tmem16a/Anoctamin 1 transcript alternative splicing [PDF]

, 2011
Background TMEM16A (Anoctamin 1; ANO1) is an eight transmembrane protein that functions as a calcium-activated chloride channel. TMEM16A in human exhibits alternatively spliced exons (6b, 13 and 15), which confer important roles in the ...
Kate E O'Driscoll, Rachel A Pipe, Fiona C Britton   +2 more
core   +1 more source

Intermolecular Interactions in the TMEM16A Dimer Controlling Channel Activity [PDF]

Scientific Reports, 2016
AbstractTMEM16A and TMEM16B are plasma membrane proteins with Ca2+-dependent Cl− channel function. By replacing the carboxy-terminus of TMEM16A with the equivalent region of TMEM16B, we obtained channels with potentiation of channel activity. Progressive shortening of the chimeric region restricted the “activating domain” to a short sequence close to ...
Scudieri, Paolo, Musante, Ilaria, Gianotti, Ambra, Moran, Oscar, Galietta, Luis J. V.   +4 more
openaire   +5 more sources

Hypoxia increases the proliferation of brain capillary endothelial cells via upregulation of TMEM16A Ca2+-activated Cl− channels

Journal of Pharmacological Sciences, 2021
The blood–brain barrier (BBB) is mainly formed by brain capillary endothelial cells (BCECs) and is exposed to hypoxic environments under pathological conditions. The effects of hypoxia on the expression and activity of Ca2+-activated Cl− (ClCa) channels,
Takahisa Suzuki, Yoshiaki Suzuki, Kiyofumi Asai, Yuji Imaizumi, Hisao Yamamura   +4 more
doaj   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Recent progress in structural studies on TMEM16A channel

Computational and Structural Biotechnology Journal, 2020
The calcium-activated chloride channel, also known as TMEM16A, shows both calcium and membrane potential dependent activation. The channel is expressed broadly and contributes to a variety of physiological processes, and it is expected to be a target for the treatment of diseases such as hypertension, pain, cystic fibrosis and lung cancer.
Sai Shi, Chunli Pang, Shuai Guo, Yafei Chen, Biao Ma, Chang Qu, Qiushuang Ji, Hailong An   +7 more
openaire   +3 more sources