Results 61 to 70 of about 4,623 (196)

Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing [PDF]

Journal of Biological Chemistry, 2009
Expression of TMEM16A protein is associated with the activity of Ca(2+)-activated Cl(-) channels. TMEM16A primary transcript undergoes alternative splicing. thus resulting in the generation of multiple isoforms. We have determined the pattern of splicing and assessed the functional properties of the corresponding TMEM16A variants.
Ferrera, Loretta, Caputo, Antonella, Ubby, Ifeoma, Bussani, Erica, Zegarra-Moran, Olga, Ravazzolo, Roberto, Pagani, Franco, Galietta, Luis J. V.   +7 more
openaire   +4 more sources

Calcium- and Voltage-Dependent Dual Gating ANO1 is an Intrinsic Determinant of Repolarization in Rod Bipolar Cells of the Mouse Retina

Cells, 2020
TMEM16A/anoctamin1 (ANO1), a calcium (Ca2+)-activated chloride (Cl−) channel, has many functions in various excitable cells and modulates excitability in both Ca2+- and voltage-gating modes.
Sun-Sook Paik, Yong Soo Park, In-Beom Kim   +2 more
doaj   +1 more source

Intestinal TMEM16A control luminal chloride secretion in a NHERF1 dependent manner

Biochemistry and Biophysics Reports, 2021
TMEM16A (Transmembrane protein 16A or Anoctamin1) is a calcium-activated chloride channel.(CaCC),that exerts critical roles in epithelial secretion. However, its localization, function, and regulation in intestinal chloride (Cl−) secretion remain obscure.
Tultul Saha, Joydeep Aoun, Mikio Hayashi, Sheikh Irshad Ali, Paramita Sarkar, Prasanta Kumar Bag, Normand Leblanc, Nadia Ameen, Owen M. Woodward, Kazi Mirajul Hoque   +9 more
doaj   +1 more source

Hypoxia increases the proliferation of brain capillary endothelial cells via upregulation of TMEM16A Ca2+-activated Cl− channels

Journal of Pharmacological Sciences, 2021
The blood–brain barrier (BBB) is mainly formed by brain capillary endothelial cells (BCECs) and is exposed to hypoxic environments under pathological conditions. The effects of hypoxia on the expression and activity of Ca2+-activated Cl− (ClCa) channels,
Takahisa Suzuki, Yoshiaki Suzuki, Kiyofumi Asai, Yuji Imaizumi, Hisao Yamamura   +4 more
doaj   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Expression of TMEM16A, cytokeratin 8 and ezrin in the olfactory epithelium of TMEM16A^-/- and TMEM16A^+/+ littermate mice.

, 2015
Confocal images of coronal sections of the olfactory epithelium from a region near the transition zone with the respiratory epithelium at E16.5 and P4 from TMEM16A-/- (A, C, E, G) or TMEM16A+/+ (B, D, F, H).
Devendra Kumar Maurya (753367), Anna Menini (266689), Nicoletta Pedemonte (383764), Tiago Henriques (753368), Jason R. Rock (247452), Monica Marini (753369), Brian D. Harfe (148989), Luis J. V. Galietta (753370)   +7 more
core   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Recent progress in structural studies on TMEM16A channel

Computational and Structural Biotechnology Journal, 2020
The calcium-activated chloride channel, also known as TMEM16A, shows both calcium and membrane potential dependent activation. The channel is expressed broadly and contributes to a variety of physiological processes, and it is expected to be a target for the treatment of diseases such as hypertension, pain, cystic fibrosis and lung cancer.
Sai Shi, Chunli Pang, Shuai Guo, Yafei Chen, Biao Ma, Chang Qu, Qiushuang Ji, Hailong An   +7 more
openaire   +3 more sources

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

TMEM16A inhibition by eugenol.

, 2012
A. Short-circuit current measured in TMEM16A-expressing FRT cells in the presence of a transepithelial Cl− gradient. Indicated concentrations of eugenol were added 10 min prior to TMEM16A activation by 1 µM ionomycin. B.
Jinhong Park (161037), A. S. Verkman (161048), Eun A. Ko (123088), Lukmanee Tradtrantip (161043), Zhen Yao (161023), Wan Namkung (161030)   +5 more
core   +1 more source