Results 61 to 70 of about 6,139 (238)

Expression of TMEM16A and SLC4A4 in Human Pancreatic Islets [PDF]

Cellular Physiology and Biochemistry, 2012
Stimulation of insulin release by D-glucose is accompanied by Cl(-) and HCO(3)(-) efflux from pancreatic islet cells. The efflux of these anions may involve volume-regulated anion channels, including possibly TMEM16A, and the Na(+)-HCO(3)(-)-cotransporter SLC4A4.
Hanzu, Felicia A, Gasa, Rosa, Bulur, Nurdan, Lybaert, Pascale, Gomis, Ramon, Malaisse, Willy, Beauwens, Renaud, Sener, Abdullah   +7 more
openaire   +3 more sources

TMEM16A Plays an Insignificant Role in Myocardium Remodeling but May Promote Angiogenesis of Heart During Pressure-overload

Frontiers in Physiology, 2022
Background: Cardiac hypertrophy (CH) occurs with an increase in myocardium mass as an adaptive compensation to increased stress. Prolonged CH causes decompensated heart failure (HF).
Yaofang Zhang, Lingyu Ye, Dayue Darrel Duan, Hong Yang, Tonghui Ma   +4 more
doaj   +1 more source

TMEM16A Ca2+-activated Cl− channel inhibition ameliorates acute pancreatitis via the IP3R/Ca2+/NFκB/IL-6 signaling pathway

Journal of Advanced Research, 2020
TMEM16A Ca2+-activated Cl− channels are expressed in pancreatic acinar cells and participate in inflammation-associated diseases. Whether TMEM16A contributes to the pathogenesis of acute pancreatitis (AP) remains unknown.
Qinghua Wang, Lichuan Bai, Shuya Luo, Tianyu Wang, Fan Yang, Jialin Xia, Hui Wang, Ke Ma, Mei Liu, Shuwei Wu, Huijie Wang, Shibin Guo, Xiaohong Sun, Qinghuan Xiao   +13 more
doaj   +1 more source

Ion permeation in TMEM16A and TMEM16F [PDF]

, 2021
TMEM16A and TMEM16F belong to the transmembrane protein 16 family. TMEM16A functions as a Ca2+-activated Cl− channel, whereas TMEM16F functions as a phospholipid scramblase that also conducts ionic current.
Nguyen, Dung Manh
core   +1 more source

TMEM16A chloride channel does not drive mucus production

Life Science Alliance, 2019
Despite being essential for airway hydration, TMEM16A is not required for mucus (MUC5AC) production. Cell proliferation is the main driver for TMEM16A up-regulation during inflammation.
Filipa B Simões, Margarida C Quaresma, Luka A Clarke, Iris AL Silva, Ines Pankonien, Violeta Railean, Arthur Kmit, Margarida D Amaral   +7 more
doaj   +1 more source

TMEM16A Mediates Mucus Production in Human Airway Epithelial Cells

, 2021
TMEM16A is a Ca2+-activated chloride channel that was shown to enhance production and secretion of mucus in inflamed airways. It is, however, not clear whether TMEM16A directly supports mucus production, or whether mucin and TMEM16A are upregulated ...
Centeio, Raquel, Wanitchakool, Podchanart, Lerias, Joana, Ousingsawat, Jiraporn, Kunzelmann, Karl, Cabrita, Inês, Benedetto, Roberta, Schreiber, Rainer   +7 more
core   +1 more source

CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A [PDF]

, 2021
TMEM16A, a Ca2+-activated chloride channel (CaCC), and its regulator, CLCA1, are associated with inflammatory airway disease and goblet cell metaplasia.
Raquel Centeio, Rainer Schreiber, Centeio, Raquel, Karl Kunzelmann, Kunzelmann, Karl, Ousingsawat, Jiraporn, Schreiber, Rainer, Jiraporn Ousingsawat   +7 more
core   +1 more source

Increased complexity of Tmem16a/Anoctamin 1 transcript alternative splicing [PDF]

, 2011
Background TMEM16A (Anoctamin 1; ANO1) is an eight transmembrane protein that functions as a calcium-activated chloride channel. TMEM16A in human exhibits alternatively spliced exons (6b, 13 and 15), which confer important roles in the ...
Fiona C Britton, Rachel A Pipe, Kate E O'Driscoll   +2 more
core   +1 more source

TMEM16A as a potential treatment target for head and neck cancer

Journal of Experimental & Clinical Cancer Research, 2022
Transmembrane protein 16A (TMEM16A) forms a plasma membrane-localized Ca2+-activated Cl- channel. Its gene has been mapped to an area on chromosome 11q13, which is amplified in head and neck squamous cell carcinoma (HNSCC).
Kohei Okuyama, Souichi Yanamoto
doaj   +1 more source

Inhibition of TMEM16A by Natural Product Silibinin: Potential Lead Compounds for Treatment of Lung Adenocarcinoma

Frontiers in Pharmacology, 2021
Background: Effective anticancer therapy can be achieved by identifying novel tumor-specific drug targets and screening of new drugs. Recently, TMEM16A has been identified to be overexpressed in lung adenocarcinoma, and inhibitors of TMEM16A showed ...
Shuai Guo, Shuai Guo, Xue Bai, Yufei Liu, Sai Shi, Xuzhao Wang, Yong Zhan, Xianjiang Kang, Yafei Chen, Hailong An   +9 more
doaj   +1 more source