Results 71 to 80 of about 6,139 (238)

TMEM16A Inhibition Preserves Blood–Brain Barrier Integrity After Ischemic Stroke

Frontiers in Cellular Neuroscience, 2019
The inflammatory response plays a pivotal role in Blood–Brain Barrier (BBB) destruction following ischemic brain injury. Enhanced leukocyte adhesion to vascular endothelial cells is an essential event in the inflammatory process.
Pin-yi Liu, Zhi Zhang, Yi Liu, Xue-lian Tang, Shu Shu, Xin-yu Bao, Yan Zhang, Yue Gu, Yun Xu, Yun Xu, Yun Xu, Yun Xu, Yun Xu, Xiang Cao, Xiang Cao, Xiang Cao, Xiang Cao, Xiang Cao   +17 more
doaj   +1 more source

Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation

Cells, 2020
Casein kinase 2 (CK2) is a highly ubiquitous and conserved serine/threonine kinase that forms a tetramer consisting of a catalytic subunit (CK2α) and a regulatory subunit (CK2β). Despite being ubiquitous, CK2 is commonly found at higher expression levels
Madalena C. Pinto, Rainer Schreiber, Joana Lerias, Jiraporn Ousingsawat, Aires Duarte, Margarida Amaral, Karl Kunzelmann   +6 more
doaj   +1 more source

TMEM16A/F support exocytosis but do not inhibit Notch-mediated goblet cell metaplasia of BCi-NS1.1 human airway epithelium

Frontiers in Physiology, 2023
Cl− channels such as the Ca2+ activated Cl− channel TMEM16A and the Cl− permeable phospholipid scramblase TMEM16F may affect the intracellular Cl− concentration ([Cl−]i), which could act as an intracellular signal.
Raquel Centeio, Inês Cabrita, Rainer Schreiber, Karl Kunzelmann   +3 more
doaj   +1 more source

ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC) [PDF]

Pflügers Archiv - European Journal of Physiology, 2014
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst survival rates of all cancers. ANO1 (TMEM16A) is a recently identified Ca(2+)-activated Cl(-) channel (CaCC) that is upregulated in several tumors. Although ANO1 was subject to extensive studies in the recent years, its pathophysiological function has only been poorly understood.
Sauter, Daniel Rafael Peter, Novak, Ivana, Pedersen, Stine Helene Falsig, Larsen, Erik Hviid, Hoffmann, Else Kay   +4 more
openaire   +4 more sources

Hepatocyte TMEM16A Deletion Retards NAFLD Progression by Ameliorating Hepatic Glucose Metabolic Disorder

Advanced Science, 2020
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease, and the mechanisms underpinning its pathogenesis have not been completely established.
Jia‐Wei Guo, Xiu Liu, Ting‐Ting Zhang, Xiao‐Chun Lin, Yu Hong, Jie Yu, Qin‐Yan Wu, Fei‐Ran Zhang, Qian‐Qian Wu, Jin‐Yan Shang, Xiao‐Fei Lv, Jing‐Song Ou, Jia‐Guo Zhou, Rui‐Ping Pang, Bao‐Dong Tang, Si‐Jia Liang   +15 more
doaj   +1 more source

Gating the pore of the calcium-activated chloride channel TMEM16A [PDF]

Nature Communications, 2021
AbstractThe binding of cytoplasmic Ca2+ to the anion-selective channel TMEM16A triggers a conformational change around its binding site that is coupled to the release of a gate at the constricted neck of an hourglass-shaped pore. By combining mutagenesis, electrophysiology, and cryo-electron microscopy, we identified three hydrophobic residues at the ...
Lam, Andy K M, Rheinberger, Jan, Paulino, Cristina, Dutzler, Raimund   +3 more
openaire   +4 more sources

Pharmacological profiling of small molecule modulators of the TMEM16A channel and their implications for the control of artery and capillary function

British Journal of Pharmacology
TMEM16A chloride channels constitute a depolarising mechanism in arterial smooth muscle cells (SMCs) and contractile cerebral pericytes. TMEM16A pharmacology is incompletely defined.
Rumaitha Al-Hosni, Emilio Agostinelli, Zeki Ilkan, Lara F. Scofano, Rachel Kaye, Ria L. Dinsdale, Kathryn E. Acheson, A. Macdonald, D. Rivers, Alice Biosa, Martin J Gunthorpe, F. Platt, Paolo Tammaro   +12 more
semanticscholar   +1 more source

Expression of TMEM16A in various nasal glands of TMEM16A^-/- and TMEM16A^+/+ littermate mice.

, 2015
Expression of TMEM16A and aquaporin 5 in the Bowman’s gland (BG), nasal septal gland (NSG) and lateral nasal gland (LNG) of TMEM16A-/- and TMEM16A+/+ littermate mice.
Devendra Kumar Maurya (753367), Anna Menini (266689), Nicoletta Pedemonte (383764), Tiago Henriques (753368), Jason R. Rock (247452), Monica Marini (753369), Brian D. Harfe (148989), Luis J. V. Galietta (753370)   +7 more
core   +1 more source

Intestinal TMEM16A control luminal chloride secretion in a NHERF1 dependent manner

Biochemistry and Biophysics Reports, 2021
TMEM16A (Transmembrane protein 16A or Anoctamin1) is a calcium-activated chloride channel.(CaCC),that exerts critical roles in epithelial secretion. However, its localization, function, and regulation in intestinal chloride (Cl−) secretion remain obscure.
Tultul Saha, Joydeep Aoun, Mikio Hayashi, Sheikh Irshad Ali, Paramita Sarkar, Prasanta Kumar Bag, Normand Leblanc, Nadia Ameen, Owen M. Woodward, Kazi Mirajul Hoque   +9 more
doaj   +1 more source

Expression of TMEM16A and ACIII in the olfactory epithelium of TMEM16A^-/- and TMEM16A^+/+ littermate mice.

, 2015
Confocal images of coronal sections of the olfactory epithelium from a region near the transition zone with the respiratory epithelium at E14.5, E16.5, E18.5 and P4.
Devendra Kumar Maurya (753367), Anna Menini (266689), Nicoletta Pedemonte (383764), Tiago Henriques (753368), Jason R. Rock (247452), Monica Marini (753369), Brian D. Harfe (148989), Luis J. V. Galietta (753370)   +7 more
core   +1 more source