Results 51 to 60 of about 4,623 (196)

Inhibition of TMEM16A by Natural Product Silibinin: Potential Lead Compounds for Treatment of Lung Adenocarcinoma

Frontiers in Pharmacology, 2021
Background: Effective anticancer therapy can be achieved by identifying novel tumor-specific drug targets and screening of new drugs. Recently, TMEM16A has been identified to be overexpressed in lung adenocarcinoma, and inhibitors of TMEM16A showed ...
Shuai Guo, Shuai Guo, Xue Bai, Yufei Liu, Sai Shi, Xuzhao Wang, Yong Zhan, Xianjiang Kang, Yafei Chen, Hailong An   +9 more
doaj   +1 more source

Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation

Cells, 2020
Casein kinase 2 (CK2) is a highly ubiquitous and conserved serine/threonine kinase that forms a tetramer consisting of a catalytic subunit (CK2α) and a regulatory subunit (CK2β). Despite being ubiquitous, CK2 is commonly found at higher expression levels
Madalena C. Pinto, Rainer Schreiber, Joana Lerias, Jiraporn Ousingsawat, Aires Duarte, Margarida Amaral, Karl Kunzelmann   +6 more
doaj   +1 more source

TMEM16A/F support exocytosis but do not inhibit Notch-mediated goblet cell metaplasia of BCi-NS1.1 human airway epithelium

Frontiers in Physiology, 2023
Cl− channels such as the Ca2+ activated Cl− channel TMEM16A and the Cl− permeable phospholipid scramblase TMEM16F may affect the intracellular Cl− concentration ([Cl−]i), which could act as an intracellular signal.
Raquel Centeio, Inês Cabrita, Rainer Schreiber, Karl Kunzelmann   +3 more
doaj   +1 more source

Ion permeation in TMEM16A and TMEM16F [PDF]

, 2021
TMEM16A and TMEM16F belong to the transmembrane protein 16 family. TMEM16A functions as a Ca2+-activated Cl− channel, whereas TMEM16F functions as a phospholipid scramblase that also conducts ionic current.
Nguyen, Dung Manh
core  

TMEM16A Inhibition Preserves Blood–Brain Barrier Integrity After Ischemic Stroke

Frontiers in Cellular Neuroscience, 2019
The inflammatory response plays a pivotal role in Blood–Brain Barrier (BBB) destruction following ischemic brain injury. Enhanced leukocyte adhesion to vascular endothelial cells is an essential event in the inflammatory process.
Pin-yi Liu, Zhi Zhang, Yi Liu, Xue-lian Tang, Shu Shu, Xin-yu Bao, Yan Zhang, Yue Gu, Yun Xu, Yun Xu, Yun Xu, Yun Xu, Yun Xu, Xiang Cao, Xiang Cao, Xiang Cao, Xiang Cao, Xiang Cao   +17 more
doaj   +1 more source

Hepatocyte TMEM16A Deletion Retards NAFLD Progression by Ameliorating Hepatic Glucose Metabolic Disorder

Advanced Science, 2020
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease, and the mechanisms underpinning its pathogenesis have not been completely established.
Jia‐Wei Guo, Xiu Liu, Ting‐Ting Zhang, Xiao‐Chun Lin, Yu Hong, Jie Yu, Qin‐Yan Wu, Fei‐Ran Zhang, Qian‐Qian Wu, Jin‐Yan Shang, Xiao‐Fei Lv, Jing‐Song Ou, Jia‐Guo Zhou, Rui‐Ping Pang, Bao‐Dong Tang, Si‐Jia Liang   +15 more
doaj   +1 more source

ER localized bestrophin1 activates Ca2+ dependent ion channels TMEM16A and SK4

, 2009
Bestrophins form Ca2+ activated Cl- channels and regulate intercellular Ca2+ signaling1. We demonstrate that bestrophin 1 is localized in the endoplasmic reticulum (ER), where it physically interacts with stromal interacting molecule 1 (Stim1), the ER ...
Rainer Schreiber, Fadi AlDehni, Kunzelmann, Karl, Ousingsawat, Jiraporn, René Barro-Soria, Karl Kunzelmann, Joana Almaça, Jiraporn Ousingsawat, Schreiber, Rainer, AlDehni, Fadi, Barro-Soria, René, Almaça, Joana, Ralph Witzgall, Witzgall, Ralph   +13 more
core   +2 more sources

Expression of TMEM16A in various nasal glands of TMEM16A^-/- and TMEM16A^+/+ littermate mice.

, 2015
Expression of TMEM16A and aquaporin 5 in the Bowman’s gland (BG), nasal septal gland (NSG) and lateral nasal gland (LNG) of TMEM16A-/- and TMEM16A+/+ littermate mice.
Devendra Kumar Maurya (753367), Anna Menini (266689), Nicoletta Pedemonte (383764), Tiago Henriques (753368), Jason R. Rock (247452), Monica Marini (753369), Brian D. Harfe (148989), Luis J. V. Galietta (753370)   +7 more
core   +1 more source

Expression of TMEM16A and ACIII in the olfactory epithelium of TMEM16A^-/- and TMEM16A^+/+ littermate mice.

, 2015
Confocal images of coronal sections of the olfactory epithelium from a region near the transition zone with the respiratory epithelium at E14.5, E16.5, E18.5 and P4.
Devendra Kumar Maurya (753367), Anna Menini (266689), Nicoletta Pedemonte (383764), Tiago Henriques (753368), Jason R. Rock (247452), Monica Marini (753369), Brian D. Harfe (148989), Luis J. V. Galietta (753370)   +7 more
core   +1 more source

Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic PAH [PDF]

, 2019
Our systematic analysis of anion channels and transporters in idiopathic pulmonary arterial hypertension (IPAH) showed marked upregulation of the Cl- channel TMEM16A gene.We hypothesised that TMEM16A overexpression might represent a novel vicious circle ...
Ghanim, Bahil, Klepetko, Walter, Olschewski, Horst, Didiasova, Miroslava, Lengyel, Miklós, Egemnazarov, Bakytbek, Maurer, Davor Skofic, Marsh, Leigh M, Nagy, Bence M, Kovacs, Gabor, Szucs, Peter, Enyedi, Péter, Nagaraj, Chandran, Sharma, Neha, Hrzenjak, Andelko, Sievers, Laura, Papp, Rita, Wygrecka, Malgorzata, Zabini, Diana, Höfler, Gerald, Olschewski, Andrea Judit, Kwapiszewska, Grazyna   +21 more
core   +1 more source