Results 51 to 60 of about 6,153 (212)
TMEM16A alternative splicing coordination in breast cancer [PDF]
Molecular Cancer, 2013 Abstract Background TMEM16A, also known as Anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors. The role of TMEM16A in cancer is not completely understood and no data are available regarding the potential tumorigenic properties of the multiple isoforms generated by ...
Ubby, Ifeoma +7 more
openaire +3 more sources
Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation
Cells, 2020 Casein kinase 2 (CK2) is a highly ubiquitous and conserved serine/threonine kinase that forms a tetramer consisting of a catalytic subunit (CK2α) and a regulatory subunit (CK2β). Despite being ubiquitous, CK2 is commonly found at higher expression levels
Madalena C. Pinto +6 more
doaj +1 more source
Frontiers in Physiology, 2023 Cl− channels such as the Ca2+ activated Cl− channel TMEM16A and the Cl− permeable phospholipid scramblase TMEM16F may affect the intracellular Cl− concentration ([Cl−]i), which could act as an intracellular signal.
Raquel Centeio +3 more
doaj +1 more source
ANO1 as a marker of oral squamous cell carcinoma and silencing ANO1 suppresses migration of human SCC-25 cells [PDF]
, 2013 Objectives: The purpose of this study is to confirm that ANO1 correlates with occurrence and metastasis of OSCC. Study Design: Immunohistochemistry was used to detect the expression of ANO1 in 160 specimens of OSCC and normal tissues.
Hong, Suling, Li, Yadong, Zhang, Jinsong
core +2 more sources
TMEM16A Inhibition Preserves Blood–Brain Barrier Integrity After Ischemic Stroke
Frontiers in Cellular Neuroscience, 2019 The inflammatory response plays a pivotal role in Blood–Brain Barrier (BBB) destruction following ischemic brain injury. Enhanced leukocyte adhesion to vascular endothelial cells is an essential event in the inflammatory process.
Pin-yi Liu +17 more
doaj +1 more source
Clinical significance of Anoctamin-1 gene at 11q13 in the development and progression of head and neck squamous cell carcinomas [PDF]
, 2015 This study investigates the clinical significance of Anoctamin-1 gene mapping at 11q13 amplicon in both the development and progression of head and neck squamous cell carcinomas (HNSCC).
Alonso Durán, Laura +10 more
core +1 more source
Advanced Science, 2020 Nonalcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease, and the mechanisms underpinning its pathogenesis have not been completely established.
Jia‐Wei Guo +15 more
doaj +1 more source
A perspective on the mechanism of the light-rise of the electro-oculogram [PDF]
, 2014 The light-rise of the electro-oculogram is believed to originate from a substance released from the rods after dark adaptation. The identity of this 'elusive' light-rise substance has not been demonstrated and therefore a new perspective on the light ...
Constable, P. A.
core +1 more source
Involvement of the transmembrane protein p23 in biosynthetic protein transport [PDF]
, 1997 The identification of ANO1/TMEM16A as the likely calcium-dependent chloride channel of exocrine glands has led to a more detailed understanding of its biophysical properties.
Alcalde +74 more
core +2 more sources
Novel roles for chloride channels, exchangers, and regulators in chronic inflammatory airway diseases [PDF]
, 2015 Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction.
Berry, Kayla N +3 more
core +4 more sources