Results 51 to 60 of about 6,139 (238)
Paneth Cell Secretion in vivo Requires Expression of Tmem16a and Tmem16f
Gastro Hep Advances, 2022 Background and Aims: Paneth cells play a central role in intestinal innate immune response. These cells are localized at the base of small intestinal crypts of Lieberkuhn.
Rainer Schreiber +2 more
doaj +1 more source
The pharmacology of the TMEM16A channel: therapeutic opportunities
Trends in Pharmacological Sciences, 2022 The TMEM16A Ca2+-gated Cl- channel is involved in a variety of vital physiological functions and may be targeted pharmacologically for therapeutic benefit in diseases such as hypertension, stroke, and cystic fibrosis (CF). The determination of the TMEM16A structure and high-throughput screening efforts, alongside ex vivo and in vivo animal studies and ...
Rumaitha Al-Hosni +3 more
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Electrophysiological Characterization of TMEM16A [PDF]
Biophysical Journal, 2015 Sweating is an essential physiological process to regulate body temperature in humans and various disorders are associated with dysregulated sweat formation.Primary sweat secretion in human eccrine sweat glands is initiated by Ca2+-activated Cl- channels (CaCC).
Bruggemann, Andrea +10 more
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Fractionation of a herbal antidiarrheal medicine reveals eugenol as an inhibitor of Ca2+-Activated Cl- channel TMEM16A. [PDF]
PLoS ONE, 2012 The Ca(2+)-activated Cl(-) channel TMEM16A is involved in epithelial fluid secretion, smooth muscle contraction and neurosensory signaling. We identified a Thai herbal antidiarrheal formulation that inhibited TMEM16A Cl(-) conductance. C18-reversed-phase
Zhen Yao +5 more
doaj +1 more source
The diverse roles of TMEM16A Ca2+-activated Cl− channels in inflammation
Journal of Advanced Research, 2021 Background: Transmembrane protein 16A (TMEM16A) Ca2+-activated Cl− channels have diverse physiological functions, such as epithelial secretion of Cl− and fluid and sensation of pain.
Weiliang Bai, Mei Liu, Qinghuan Xiao
doaj +1 more source
Arctigenin Attenuates Vascular Inflammation Induced by High Salt through TMEM16A/ESM1/VCAM-1 Pathway
Biomedicines, 2022 Salt-sensitive hypertension is closely related to inflammation, but the mechanism is barely known. Transmembrane member 16A (TMEM16A) is the Ca2+-activated chloride channel in epithelial cells, smooth muscle cells, and sensory neurons.
Mengying Zeng +5 more
doaj +1 more source
The Molecular Mechanism of Ginsenoside Analogs Activating TMEM16A [PDF]
Biophysical Journal, 2020 The calcium-activated chloride channel TMEM16A is involved in many physiological processes, and insufficient function of TMEM16A may lead to the occurrence of various diseases. Therefore, TMEM16A activators are supposed to be potentially useful for treatment of TMEM16A downregulation-inducing diseases.
Shuai Guo +7 more
openaire +2 more sources
Reduced Expression of TMEM16A Impairs Nitric Oxide-Dependent Cl− Transport in Retinal Amacrine Cells
Frontiers in Cellular Neuroscience, 2022 Postsynaptic cytosolic Cl− concentration determines whether GABAergic and glycinergic synapses are inhibitory or excitatory. We have shown that nitric oxide (NO) initiates the release of Cl− from acidic internal stores into the cytosol of retinal ...
Tyler Christopher Rodriguez +3 more
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ER localized bestrophin1 activates Ca2+ dependent ion channels TMEM16A and SK4 [PDF]
, 2009 Bestrophins form Ca2+ activated Cl- channels and regulate intercellular Ca2+ signaling1. We demonstrate that bestrophin 1 is localized in the endoplasmic reticulum (ER), where it physically interacts with stromal interacting molecule 1 (Stim1), the ER ...
Rainer Schreiber +13 more
core +1 more source
Acta Pharmaceutica Sinica B, 2021 Vascular smooth muscle cell (VSMC) migration plays a critical role in the pathogenesis of many cardiovascular diseases. We recently showed that TMEM16A is involved in hypertension-induced cerebrovascular remodeling.
Huaqing Zheng +10 more
doaj +1 more source