Results 31 to 40 of about 6,139 (238)
Interplay of Ca<sup>2+</sup> and PIP<sub>2</sub> in TMEM16A channel function. [PDF]
J PhysiolThe transmembrane member 16A (TMEM16A) forms a Ca2+‐activated Cl− channel with widespread expression and diverse physiological roles. Activating these channels requires both Ca2+ and the acidic phospholipid phosphatidylinositol 4,5‐bisphosphate (PIP2 ...
Lara-Santos C +4 more
europepmc +2 more sources
The Prognostic Value and Mechanisms of TMEM16A in Human Cancer [PDF]
Frontiers in Molecular Biosciences, 2021 As a calcium ion-dependent chloride channel transmembrane protein 16A (TMEM16A) locates on the cell membrane. Numerous research results have shown that TMEM16A is abnormally expressed in many cancers.
Wenjian Chen +11 more
doaj +3 more sources
Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer
Molecular Cancer, 2017 TMEM16A (known as anoctamin 1) Ca2+-activated chloride channel is overexpressed in many tumors. TMEM16A overexpression can be caused by gene amplification in many tumors harboring 11q13 amplification.
Hui Wang +6 more
doaj +2 more sources
TMEM16A in prostate cancer: mechanistic insights and therapeutic implications. [PDF]
Cancer Cell IntTransmembrane protein 16A (TMEM16A), functions as a calcium-activated chloride channel and has been recognized as a crucial factor in the pathophysiological processes of prostate cancer. Its elevated expression in metastatic prostate cancer cell lines is
He JW, Li PZ, Huang ZX.
europepmc +2 more sources
The role and regulation of TMEM16A in the vascular system [PDF]
, 2020 TMEM16A is a Ca2+-activated Cl- channel (CaCC) encoded by the TMEM16A gene, expressed in vascular smooth muscle cells (VSMCs). TMEM16A has a proposed role in depolarising the membrane potential (Vm) in response to activation of the Gq-protein coupled ...
Acheson, Kathryn
core +2 more sources
PLoS ONE, 2015 TMEM16A, a calcium-activated chloride channel (CaCC), is highly amplified and expressed in human cancers and is involved in the growth and metastasis of some malignancies. Inhibition of TMEM16A represents a novel pharmaceutical approach for the treatment
Yujie Sui +11 more
doaj +2 more sources
TMEM16A alternative splicing coordination in breast cancer [PDF]
Molecular Cancer, 2013 BACKGROUND: TMEM16A, also known as Anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors. The role of TMEM16A in cancer is not completely understood and no data are available regarding the potential tumorigenic ...
Luis Galietta +23 more
core +5 more sources
Molecular Mechanisms of Electric Signals Generated at Corneal Wounds [PDF]
The FASEB Journal, Volume 40, Issue 16, 31 August 2026.Corneal injury triggers cell signaling (including calcium waves) leading to ion channel up‐regulation, increased ion pumping, and enhanced wound electric signals which stimulate wound healing. ABSTRACT Over 150 years ago, it was demonstrated that wounds produce electric fields and currents.
Brian Reid, Guillaume Luxardi, Min Zhao
wiley +2 more sources
Intermolecular interactions in the TMEM16A dimer controlling channel activity [PDF]
Scientific Reports, 2016 TMEM16A and TMEM16B are plasma membrane proteins with Ca2+-dependent Cl- channel function. By replacing the carboxy-terminus of TMEM16A with the equivalent region of TMEM16B, we obtained channels with potentiation of channel activity.
Gianotti A. +9 more
core +6 more sources
TMEM16A (ANO1) as a therapeutic target in cystic fibrosis
Current Opinion in Pharmacology, 2022 Cystic fibrosis (CF) is a multi-organ genetic disease caused by loss of function of CFTR, a cAMP-regulated chloride channel expressed in epithelial cells.
Galietta, L
core +4 more sources