Results 31 to 40 of about 4,623 (196)

TMEM16A inhibition suppresses melanoma metastasis. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Zhou N, Pei C, Lu X, Shi P, Wu S, Chen H.   +5 more
europepmc   +3 more sources

Restoring chloride efflux in cystic fibrosis with TMEM16a antisense oligonucleotides. [PDF]

Mol Ther
International audiencePatients with cystic fibrosis (CF) who are non-responsive to treatments due to specific mutations need alternative CFTR-independent therapies. This study aims to assess the impact of TMEM16a expression by a specific oligonucleotide (
Mitri C, Rousselet N, Bardin P, Dias Wickramanayaka M, Foussignière T, Dupuis G, Leblanc M, Gournet V, Sonneville F, Corvol H, Tabary O.   +10 more
europepmc   +2 more sources

Expression of TMEM16A in Colorectal Cancer and Its Correlation With Clinical and Pathological Parameters

Frontiers in Oncology, 2021
TMEM16A is a recently identified calcium-activated chloride channel (CaCC) and its overexpression contributes to tumorigenesis and progression in several human malignancies.
Hongxia Li, Qiwei Yang, Sibo Huo, Sibo Huo, Zhenwu Du, Zhenwu Du, Fei Wu, Haiyue Zhao, Shifan Chen, Longfei Yang, Zhiming Ma, Yujie Sui   +11 more
doaj   +1 more source

TMEM16A in gastrointestinal and vascular smooth muscle contractility. [PDF]

J Physiol
AbstractCalcium‐activated Cl− channels (CaCC) are widely expressed proteins which regulate various physiological functions. TMEM16A is a CaCC expressed in the gastrointestinal and cardiovascular systems, where it is a major regulator of tissue contraction.
Tas ST, Anderson MO, Cil O.
europepmc   +3 more sources

Activation of TMEM16A Ca2+-activated Cl− channels by ROCK1/moesin promotes breast cancer metastasis

Journal of Advanced Research, 2021
Introduction: Transmembrane protein 16A (TMEM16A) is a Ca2+-activated chloride channel that plays a role in cancer cell proliferation, migration, invasion, and metastasis.
Shuya Luo, Hui Wang, Lichuan Bai, Yiwen Chen, Si Chen, Kuan Gao, Huijie Wang, Shuwei Wu, Hanbin Song, Ke Ma, Mei Liu, Fan Yao, Yue Fang, Qinghuan Xiao   +13 more
doaj   +1 more source

The pharmacology of the TMEM16A channel: therapeutic opportunities

Trends in Pharmacological Sciences, 2022
The TMEM16A Ca2+-gated Cl- channel is involved in a variety of vital physiological functions and may be targeted pharmacologically for therapeutic benefit in diseases such as hypertension, stroke, and cystic fibrosis (CF). The determination of the TMEM16A structure and high-throughput screening efforts, alongside ex vivo and in vivo animal studies and ...
Rumaitha Al-Hosni, Zeki Ilkan, Emilio Agostinelli, Paolo Tammaro   +3 more
openaire   +2 more sources

The Molecular Mechanism of Ginsenoside Analogs Activating TMEM16A [PDF]

Biophysical Journal, 2020
The calcium-activated chloride channel TMEM16A is involved in many physiological processes, and insufficient function of TMEM16A may lead to the occurrence of various diseases. Therefore, TMEM16A activators are supposed to be potentially useful for treatment of TMEM16A downregulation-inducing diseases.
Shuai Guo, Yafei F. Chen, Sai Shi, Chunli L. Pang, Xuzhao Z. Wang, Hailin L. Zhang, Yong Zhan, Hailong L. An   +7 more
openaire   +2 more sources

Electrophysiological Characterization of TMEM16A [PDF]

Biophysical Journal, 2015
Sweating is an essential physiological process to regulate body temperature in humans and various disorders are associated with dysregulated sweat formation.Primary sweat secretion in human eccrine sweat glands is initiated by Ca2+-activated Cl- channels (CaCC).
Bruggemann, Andrea, Rapedius, Markus, Götze, Tom, Haarmann, Claudia, Rinke, Ilka, Vogel, Marius, Stengel, Timo, Stiehler, Johannes, George, Michael, Fertig, Niels, Ertongur-Fauth, Torsten   +10 more
openaire   +1 more source

Niclosamide potentiates TMEM16A and induces vasoconstriction

Biophysical Journal, 2023
ABSTRACT The TMEM16A calcium-activated chloride channel is a promising therapeutic target for various diseases. Niclosamide, an anthelmintic medication, has been considered as a TMEM16A inhibitor for treating asthma and chronic obstructive pulmonary disease, but was recently found to possess broad-spectrum off-target effects.
Pengfei Liang, Yui Chun S. Wan, Kuai Yu, H. Criss Hartzell, Huanghe Yang   +4 more
openaire   +3 more sources

Paneth Cell Secretion in vivo Requires Expression of Tmem16a and Tmem16f

Gastro Hep Advances, 2022
Background and Aims: Paneth cells play a central role in intestinal innate immune response. These cells are localized at the base of small intestinal crypts of Lieberkuhn.
Rainer Schreiber, Ines Cabrita, Karl Kunzelmann   +2 more
doaj   +1 more source