Results 21 to 30 of about 3,802 (167)

Co-targeting TMEM16A with a novel monoclonal antibody and EGFR with Cetuximab inhibits the growth and metastasis of esophageal squamous cell carcinoma [PDF]

Journal of Translational Medicine
The chloride channel transmembrane protein 16A (TMEM16A) possesses a calcium-activated property linked to tumor-promoting malignant phenotype and electrophysiological stability.
Yutian Zheng, Lin Meng, Like Qu, Chuanke Zhao, Lixin Wang, Jiayi Ma, Caiyun Liu, Chengchao Shou   +7 more
doaj   +2 more sources

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +3 more sources

Identification of novel TMEM16A blockers through integrated virtual screening, molecular dynamics, and experimental studies [PDF]

Scientific Reports
The calcium-activated chloride channel TMEM16A is a promising drug target for treating hypertension, secretory diarrheas, and various cancers, including head and neck cancer. Despite its potential, no FDA-approved drugs have provided the structural basis
Mattanun Sangkhawasi, Wichuda Pitaktrakul, Rungtiwa Khumjiang, Yasuteru Shigeta, Chatchai Muanprasat, Kowit Hengphasatporn, Thanyada Rungrotmongkol   +6 more
doaj   +2 more sources

TMEM16A in Cystic Fibrosis: Activating or Inhibiting? [PDF]

Frontiers in Pharmacology, 2019
The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction.
Karl Kunzelmann, Jiraporn Ousingsawat, Inês Cabrita, Tereza Doušová, Andrea Bähr, Andrea Bähr, Melanie Janda, Rainer Schreiber, Roberta Benedetto   +8 more
doaj   +5 more sources

TMEM16A inhibition suppresses melanoma metastasis. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Zhou N, Pei C, Lu X, Shi P, Wu S, Chen H.   +5 more
europepmc   +3 more sources

Calmodulin-Dependent Regulation of Overexpressed but Not Endogenous TMEM16A Expressed in Airway Epithelial Cells

Membranes, 2021
Regulation of the Ca2+-activated Cl− channel TMEM16A by Ca2+/calmodulin (CAM) is discussed controversially. In the present study, we compared regulation of TMEM16A by Ca2+/calmodulin (holo-CAM), CAM-dependent kinase (CAMKII), and CAM-dependent ...
Khaoula Talbi, Jiraporn Ousingsawat, Raquel Centeio, Rainer Schreiber, Karl Kunzelmann   +4 more
doaj   +1 more source

Hepatocyte-specific TMEM16A deficiency alleviates hepatic ischemia/reperfusion injury via suppressing GPX4-mediated ferroptosis

Cell Death and Disease, 2022
Ischemia/reperfusion (I/R)-induced liver injury with severe cell death is a major complication of liver transplantation. Transmembrane member 16A (TMEM16A), a component of hepatocyte Ca2+-activated chloride channel, has been implicated in a variety of ...
Jiawei Guo, Zihao Song, Jie Yu, Chengyi Li, Chenchen Jin, Wei Duan, Xiu Liu, Yingying Liu, Shuai Huang, Yonghua Tuo, Fei Pei, Zhengyang Jian, Pengyu Zhou, Shaoyi Zheng, Zhaowei Zou, Feng Zhang, Quan Gong, Sijia Liang   +17 more
doaj   +1 more source

The Calcium-Activated Chloride Channel TMEM16A is Inhibitied by Liquiritigenin

Frontiers in Pharmacology, 2021
The transmembrane 16 (TMEM16) family contains 10 subtypes, and the function of each protein is different. TMEM16A is a calcium-activated chloride channel involved in physiological and pathological situations.
Mami Kato, Yasunori Takayama, Masataka Sunagawa   +2 more
doaj   +1 more source

Activation of TMEM16A Ca2+-activated Cl− channels by ROCK1/moesin promotes breast cancer metastasis

Journal of Advanced Research, 2021
Introduction: Transmembrane protein 16A (TMEM16A) is a Ca2+-activated chloride channel that plays a role in cancer cell proliferation, migration, invasion, and metastasis.
Shuya Luo, Hui Wang, Lichuan Bai, Yiwen Chen, Si Chen, Kuan Gao, Huijie Wang, Shuwei Wu, Hanbin Song, Ke Ma, Mei Liu, Fan Yao, Yue Fang, Qinghuan Xiao   +13 more
doaj   +1 more source

Expression of TMEM16A in Colorectal Cancer and Its Correlation With Clinical and Pathological Parameters

Frontiers in Oncology, 2021
TMEM16A is a recently identified calcium-activated chloride channel (CaCC) and its overexpression contributes to tumorigenesis and progression in several human malignancies.
Hongxia Li, Qiwei Yang, Sibo Huo, Sibo Huo, Zhenwu Du, Zhenwu Du, Fei Wu, Haiyue Zhao, Shifan Chen, Longfei Yang, Zhiming Ma, Yujie Sui   +11 more
doaj   +1 more source