Results 21 to 30 of about 6,139 (238)

Ca2+‐Activated Cl− Channels: Do Bestrophins and TMEM16A Interact? [PDF]

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Ca2+‐activated Cl– conductances are present in many cell types and are important for regulating membrane potential as well as other cellular functions. TMEM16A is widely accepted as the principal molecular basis for Ca2+‐activated Cl– conductances, but also members of the bestrophin family may be important for some Ca2+‐activated Cl ...
Christian Aalkjær, Vibeke Secher Dam, Holger Nilsson, Donna B. Boedtkjer, Vladimir Matchkov   +4 more
wiley   +2 more sources

Epithelial chloride transport by CFTR requires TMEM16A [PDF]

Scientific Reports, 2017
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is the secretory chloride/bicarbonate channel in airways and intestine that is activated through ATP binding and phosphorylation by protein kinase A, but fails to operate in cystic fibrosis (CF).
Michael J. Holtzman, Rainer Schreiber, Podchanart Wanitchakool, Wanitchakool, Podchanart, Amaral, Margarida, Kunzelmann, Karl, Benedetto, Roberta, Schreiber, Rainer, Rock, Jason R., Yong Zhang, Margarida Amaral, Rock, Jason R, Holtzman, Michael J, Karl Kunzelmann, Ousingsawat, Jiraporn, Jiraporn Ousingsawat, Holtzman, Michael J., Roberta Benedetto, Jason R. Rock, Zhang, Yong   +19 more
core   +5 more sources

The Calcium-Activated Chloride Channel TMEM16A is Inhibitied by Liquiritigenin

Frontiers in Pharmacology, 2021
The transmembrane 16 (TMEM16) family contains 10 subtypes, and the function of each protein is different. TMEM16A is a calcium-activated chloride channel involved in physiological and pathological situations.
Masataka Sunagawa, Mami Kato, Yasunori Takayama   +2 more
exaly   +3 more sources

Control of Ion Transport by Tmem16a Expressed in Murine Intestine [PDF]

Frontiers in Physiology, 2019
Cl– secretion by the human and murine intestinal epithelium occurs through the cystic fibrosis transmembrane conductance regulator (cftr). However, the Ca2+ activated Cl– channel Tmem16a was shown to contribute to Cl– secretion, mainly, but not ...
Karl Kunzelmann, Raquel Centeio, Podchanart Wanitchakool, Inês Cabrita, Roberta Benedetto, Tultul Saha, Kazi Mirajul Hoque, Kazi Mirajul Hoque, Rainer Schreiber   +8 more
doaj   +2 more sources

The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury

JCI Insight
The role played by anionic channels in diabetic kidney disease (DKD) is not known. Chloride channel accessory 1 (CLCA1) facilitates the activity of TMEM16A (Anoctamin-1), a Ca2+-dependent Cl– channel. We examined if CLCA1/TMEM16A had a role in DKD.
Hak Joo Lee, Yuyang Sun, Falguni Das, Wenjun Ju, Viji Nair, Christopher G. Kevil, Shankara Varadarajan, Guanshi Zhang, Goutam Ghosh Choudhury, Brij B. Singh, Matthias Kretzler, Robert G. Nelson, Kumar Sharma, Balakuntalam S. Kasinath   +13 more
doaj   +2 more sources

Calcium-activated chloride channel TMEM16A opens via pi-helical transition in transmembrane segment 4. [PDF]

Proc Natl Acad Sci U S A
Significance TMEM16A is an anion channel whose main physiological function is to couple chloride conduction to the level of intracellular Ca2+. Despite physiological importance and high pharmacological potential of TMEM16A, its gating mechanism remains ...
Kostritskii AY, Kostritskaia Y, Dmitrieva N, Stauber T, Machtens JP.   +4 more
europepmc   +2 more sources

Renin‐Angiotensin Signaling and Vascular Function: Insights into Health and Disease [PDF]

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT The renin‐angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications.
Giovanni Bertoldi, Swapnil K. Sonkusare
wiley   +2 more sources

Afatinib amplifies cAMP-induced fluid secretion in a mouse mini-gut model via TMEM16A-mediated fluid secretion and secretory cell differentiation. [PDF]

Sci Rep
Afatinib is an effective treatment of metastatic non-small cell lung cancer, despite the occurrence of its common gastrointestinal toxicities especially diarrheas, which lead to dose adjustments or treatment cessation in severe cases.
Ariyadamrongkwan J, Satitsri S, Khumjiang R, Muanprasat C.   +3 more
europepmc   +2 more sources

TMEM16A Maintains Acrosomal Integrity Through ERK1/2, RhoA, and Actin Cytoskeleton During Capacitation. [PDF]

Int J Mol Sci
Mammalian spermatozoa undergo a series of physiological and biochemical changes in the oviduct that lead them to acquire the ability to fertilize eggs.
Roa-Espitia AL, Reyes-Miguel T, Salgado-Lucio ML, Cordero-Martínez J, Tafoya-Domínguez D, Hernández-González EO.   +5 more
europepmc   +2 more sources

Functional expression of TMEM16A in taste bud cells [PDF]

The Journal of Physiology, 2021
Key points: Taste transduction occurs in taste buds in the tongue epithelium. The Ca2+-activated Cl– channels TMEM16A and TMEM16B play relevant physiological roles in several sensory systems. Here, we report that TMEM16A, but not TMEM16B, is expressed in
Pifferi S., Gonzalez-Velandia K. Y., Hernandez-Clavijo A., Menini A., Guarascio D. M.   +4 more
core   +5 more sources