Results 11 to 20 of about 6,139 (238)

Development of the Olfactory Epithelium and Nasal Glands in TMEM16A-/- and TMEM16A+/+ Mice. [PDF]

PLoS ONE, 2015
TMEM16A/ANO1 is a calcium-activated chloride channel expressed in several types of epithelia and involved in various physiological processes, including proliferation and development.
Devendra Kumar Maurya, Tiago Henriques, Monica Marini, Nicoletta Pedemonte, Luis J V Galietta, Jason R Rock, Brian D Harfe, Anna Menini   +7 more
doaj   +10 more sources

Restoring chloride efflux in cystic fibrosis with TMEM16a antisense oligonucleotides. [PDF]

Mol Ther
Patients with cystic fibrosis (CF) who are non-responsive to treatments due to specific mutations need alternative CF transmembrane conductance regulator (CFTR)-independent therapies.
Mitri C, Rousselet N, Bardin P, Dias Wickramanayaka M, Foussignière T, Dupuis G, Leblanc M, Gournet V, Sonneville F, Corvol H, Tabary O.   +10 more
europepmc   +3 more sources

TMEM16A in gastrointestinal and vascular smooth muscle contractility. [PDF]

J Physiol
Calcium-activated Cl− channels (CaCC) are widely-expressed proteins which regulate various physiological functions. TMEM16A is a CaCC expressed in the gastrointestinal and cardiovascular systems, where it is a major regulator of tissue contraction.
Tas ST, Anderson MO, Cil O.
europepmc   +4 more sources

Intracellular TMEM16A is necessary for myogenesis of skeletal muscle [PDF]

iScience, 2022
Summary: Transmembrane protein 16A (TMEM16A) localizes at plasma membrane and controls chloride influx in various type of cells. We here showed an intracellular localization pattern of TMEM16A molecules.
Wen Yuan, Cong-Cong Cui, Jing Li, Yan-Hua Xu, Chun-E Fan, Yu-Chen Chen, Hong-Wei Fan, Bing-Xue Hu, Mei-Yun Shi, Zhi-Yuan Sun, Pei Wang, Teng-Xiang Ma, Zhao Zhang, Min-Sheng Zhu, Hua-Qun Chen   +14 more
doaj   +4 more sources

TMEM16A inhibition suppresses melanoma metastasis. [PDF]

Acta Biochim Biophys Sin (Shanghai)
As a highly aggressive malignancy arising from melanocytes, malignant melanoma accounts for the majority of skin cancer - related deaths worldwide. Metastases, particularly lung and brain metastases, contribute significantly to mortality [1].
Zhou N, Pei C, Lu X, Shi P, Wu S, Chen H.   +5 more
europepmc   +4 more sources

TMEM16A in Cystic Fibrosis: Activating or Inhibiting? [PDF]

Frontiers in Pharmacology, 2019
The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction.
Karl Kunzelmann, Jiraporn Ousingsawat, Inês Cabrita, Tereza Doušová, Andrea Bähr, Andrea Bähr, Melanie Janda, Rainer Schreiber, Roberta Benedetto   +8 more
doaj   +6 more sources

Identification of novel TMEM16A blockers through integrated virtual screening, molecular dynamics, and experimental studies [PDF]

Scientific Reports
The calcium-activated chloride channel TMEM16A is a promising drug target for treating hypertension, secretory diarrheas, and various cancers, including head and neck cancer. Despite its potential, no FDA-approved drugs have provided the structural basis
Mattanun Sangkhawasi, Wichuda Pitaktrakul, Rungtiwa Khumjiang, Yasuteru Shigeta, Chatchai Muanprasat, Kowit Hengphasatporn, Thanyada Rungrotmongkol   +6 more
doaj   +3 more sources

Carrier-free procyanidin-ferric nanonetworks loading gefitinib to inhibit TMEM16A-EGFR mutual activation loop for photothermally enhanced breast cancer targeted therapy. [PDF]

Mater Today Bio
The calcium-activated chloride channel TMEM16A is frequently overexpressed in breast cancer, establishing a reciprocal activation loop with EGFR signaling pathways that play a crucial role in the proliferation of breast cancer.
Li G, Cai C, Zhang N, Wang Z, Zhang M, Liu Q, Chen S, Shang Y, Zhao C, Ren S, An H.   +10 more
europepmc   +2 more sources

Hepatocyte-specific TMEM16A deficiency alleviates hepatic ischemia/reperfusion injury via suppressing GPX4-mediated ferroptosis

Cell Death and Disease, 2022
Ischemia/reperfusion (I/R)-induced liver injury with severe cell death is a major complication of liver transplantation. Transmembrane member 16A (TMEM16A), a component of hepatocyte Ca2+-activated chloride channel, has been implicated in a variety of ...
Jiawei Guo, Zihao Song, Jie Yu, Chengyi Li, Chenchen Jin, Wei Duan, Xiu Liu, Yingying Liu, Shuai Huang, Yonghua Tuo, Fei Pei, Zhengyang Jian, Pengyu Zhou, Shaoyi Zheng, Zhaowei Zou, Feng Zhang, Quan Gong, Sijia Liang   +17 more
doaj   +2 more sources

Calmodulin-Dependent Regulation of Overexpressed but Not Endogenous TMEM16A Expressed in Airway Epithelial Cells [PDF]

Membranes, 2021
Regulation of the Ca2+-activated Cl− channel TMEM16A by Ca2+/calmodulin (CAM) is discussed controversially. In the present study, we compared regulation of TMEM16A by Ca2+/calmodulin (holo-CAM), CAM-dependent kinase (CAMKII), and CAM-dependent ...
Khaoula Talbi, Jiraporn Ousingsawat, Raquel Centeio, Rainer Schreiber, Karl Kunzelmann   +4 more
doaj   +2 more sources