Development of the Olfactory Epithelium and Nasal Glands in TMEM16A-/- and TMEM16A+/+ Mice. [PDF]
PLoS ONE, 2015 TMEM16A/ANO1 is a calcium-activated chloride channel expressed in several types of epithelia and involved in various physiological processes, including proliferation and development.
Devendra Kumar Maurya +7 more
doaj +8 more sources
Intracellular TMEM16A is necessary for myogenesis of skeletal muscle
iScience, 2022 Summary: Transmembrane protein 16A (TMEM16A) localizes at plasma membrane and controls chloride influx in various type of cells. We here showed an intracellular localization pattern of TMEM16A molecules.
Wen Yuan +14 more
doaj +3 more sources
TMEM16A in gastrointestinal and vascular smooth muscle contractility. [PDF]
J PhysiolAbstractCalcium‐activated Cl− channels (CaCC) are widely expressed proteins which regulate various physiological functions. TMEM16A is a CaCC expressed in the gastrointestinal and cardiovascular systems, where it is a major regulator of tissue contraction.
Tas ST, Anderson MO, Cil O.
europepmc +3 more sources
The Prognostic Value and Mechanisms of TMEM16A in Human Cancer [PDF]
Frontiers in Molecular Biosciences, 2021 As a calcium ion-dependent chloride channel transmembrane protein 16A (TMEM16A) locates on the cell membrane. Numerous research results have shown that TMEM16A is abnormally expressed in many cancers.
Wenjian Chen +11 more
doaj +3 more sources
TMEM16A Contributes to Calcium‐Activated Chloride Currents and Membrane Potential Changes in the Mouse Oocyte [PDF]
Journal of Cellular Physiology, Volume 241, Issue 3, March 2026.ABSTRACT Oscillations in intracellular Ca2+ [Ca2+]i are essential for mouse oocyte activation following fertilization. These [Ca2+]i oscillations also induce repetitive hyperpolarizations in the membrane potential (Em). The present study aimed to identify the channels underlying the Em hyperpolarizations.
Sarah Dalati +2 more
wiley +2 more sources
Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7‐Polarized Microfilament Coordination in Breast Cancer Cells [PDF]
Advanced Science, Volume 13, Issue 13, 3 March 2026.This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Ling Zhu +10 more
wiley +2 more sources
Isolation and long‐term culture of primary mouse cholangiocytes that retain biophysical properties and distinct Cl‐conductances: An initial study [PDF]
Physiological Reports, Volume 14, Issue 2, January 2026.Mouse cholangiocytes are isolated from bile ducts and cultured in conditioned medium containing ROCK inhibitor. Cells maintain expression of biliary markers & ion channel activity for >50 passages. Abstract Cultures of primary mouse bile duct epithelial cells are a valuable tool to study cholangiocyte secretion and bile formation.
Qin Li +4 more
wiley +2 more sources
The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury [PDF]
JCI InsightThe role played by anionic channels in diabetic kidney disease (DKD) is not known. Chloride channel accessory 1 (CLCA1) facilitates the activity of TMEM16A (Anoctamin-1), a Ca2+-dependent Cl– channel. We examined if CLCA1/TMEM16A had a role in DKD.
Hak Joo Lee +13 more
doaj +2 more sources
Studying the Influence of the Subunit Arrangement on the Function of Heterotetrameric Olfactory CNG Channels [PDF]
Biophysical Journal, 2015 Sweating is an essential physiological process to regulate body temperature in humans and various disorders are associated with dysregulated sweat formation.Primary sweat secretion in human eccrine sweat glands is initiated by Ca2+-activated Cl- channels (CaCC).
Schirmeyer, Jana +4 more
core +3 more sources
Co-targeting TMEM16A with a novel monoclonal antibody and EGFR with Cetuximab inhibits the growth and metastasis of esophageal squamous cell carcinoma [PDF]
Journal of Translational MedicineThe chloride channel transmembrane protein 16A (TMEM16A) possesses a calcium-activated property linked to tumor-promoting malignant phenotype and electrophysiological stability.
Yutian Zheng +7 more
doaj +2 more sources