Results 91 to 100 of about 6,153 (212)

HIF‐Regulated Pannexin‐1 Channel Drives Luminal ATP Accumulation in Kidney Cysts

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Kathrin Skoczynski, Julia Katharina Scholz, Raluca Ursu, Johannes Schödel, Steffen Grampp, Stephanie Naas, Victoria Lauer, Mario Schiffer, Maike Büttner‐Herold, Bjoern Buchholz, Andre Kraus   +10 more
wiley   +1 more source

Ca2+ tunnelling through the ER lumen as a mechanism for delivering Ca2+ entering via store-operated Ca2+ channels to specific target sites [PDF]

, 2017
Ca2+ signaling is perhaps the most universal and versatile mechanism regulating a wide range of cellular processes. Because of the many different calcium-binding proteins distributed throughout cells, signaling precision requires localized rises in the ...
Courjaret, Raphael, Machaca, Khaled, Petersen, Ole Holger   +2 more
core   +2 more sources

TMEM92 shields DDX3X from TTC3‐mediated degradation to confer chemoresistance in triple‐negative breast cancer

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
TMEM92 protects DDX3X from degradation by the E3 ligase TTC3, promoting TNBC cell proliferation and tumour growth. Depleting TMEM92 not only suppresses tumour growth but also sensitises cells to cisplatin, suggesting that targeting this axis is a potential therapeutic strategy.
Hao Shen, Xiaochao Jia, Xu Li, Zhi Li, Zhihua Zhang, Yang Zhao, Lei Shen, Xiaoqiu Bu, Qiang Ma, Chunli Liang, Xiaoti Lin, Lin‐Xiaoxi Ma, Chuan Qin   +12 more
wiley   +1 more source

TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension [PDF]

British Journal of Pharmacology, 2019
Background and PurposeCoronary artery disease leads to ischaemic heart disease and ultimately myocardial infarction. Thus, it is important to determine the factors that regulate coronary blood flow. Ca2+‐activated chloride channels contribute to the regulation of arterial tone; however, their role in coronary arteries is unknown.
Henry R. Askew Page, Thomas Dalsgaard, Samuel N. Baldwin, Thomas A. Jepps, Oleksandr Povstyan, Søren P. Olesen, Iain A. Greenwood   +6 more
openaire   +5 more sources

Potentiating TMEM16A does not stimulate airway mucus secretion or bronchial and pulmonary arterial smooth muscle contraction

FASEB BioAdvances, 2020
The calcium‐activated chloride channel (CaCC) TMEM16A enables chloride secretion across several transporting epithelia, including in the airways. Additional roles for TMEM16A have been proposed, which include regulating mucus production and secretion and
Henry Danahay, Roy Fox, Sarah Lilley, Holly Charlton, Kathryn Adley, Lee Christie, Ejaz Ansari, Camille Ehre, Alexis Flen, Michael J. Tuvim, Burton F. Dickey, Colin Williams, Sarah Beaudoin, Stephen P Collingwood, Martin Gosling   +14 more
doaj   +1 more source

Erk1/2 activation and modulation of STAT3 signaling in oral cancer [PDF]

, 2014
Constitutive activation of the signal transducer and activator of transcription 3 (STAT3) signaling pathway possesses confirmed oncogenic potential in oral squamous cell carcinoma (OSCC).
Aggarwal, Aguzzi, Ahmed, ALEXANDRA SKLAVOUNOU, Anjum, Balmanno, Bancroft, Bessard, Bromberg, Bromberg, Chen, Chen, Choi, Chung, Curado, Decker, Dhillon, Dumesic, Dunn, Duvvuri, Gao, GEORGE RASSIDAKIS, Gough, Grandis, Hazan-Halevy, IOANNIS GKOUVERIS, Jain, Jewett, Ji, Johnson, Judd, Katada, Kijima, Kovarik, Lai, Lavoie, Lee, Lee, Lee, Leeman, Li, Li, Lim, Lin, Maggioni, MARIA KARANIKOU, Mendoza, Miyakoshi, Molinolo, Naher, Nelson, Nikitakis, NIKOLAOS NIKITAKIS, Obajimi, O’Shea, Pearce, Quadros, Rane, Reich, Sakaguchi, Sengupta, Si, Siavash, Smalley, Song, Sumimoto, Tkach, Venkatasubbarao, Wakahara, Wang, Wierenga, Xue, Zhao, Zuo   +73 more
core   +1 more source

The role of TMEM16A (ANO1) and TMEM16F (ANO6) in cell migration [PDF]

Pflügers Archiv - European Journal of Physiology, 2013
Members of the TMEM16 family have recently been described as Ca(2+)-activated Cl(-) channels. They have been implicated in cancer and appear to be associated with poor patient prognosis. Here, we investigate the role of TMEM16 channels in cell migration, which is largely unknown.
Jacobsen, K.S., Zeeberg, K., Sauter, Daniel Rafael Peter, Poulsen, K.A., Hoffmann, Else Kay, Schwab, A.   +5 more
openaire   +4 more sources

The ciliary GTPase Arl13b regulates cell migration and cell cycle progression [PDF]

, 2016
Acknowledgments We acknowledge Prof. Tamara Caspary from Emory University for kindly providing the cell lines, Linda Duncan from the University of Aberdeen Ian Fraser Cytometry Center for help with flow cytometry.
Clancy, Hannah, Ding, Yu-Qiang, Lang, Bing, McCaig, Colin D., Pruski, Michal, Rajnicek, Ann, Yang, Zhifu   +6 more
core   +2 more sources

Pathogenesis of Age‐Related Hearing Loss and Therapeutic Strategies

Sensory Neuroscience, Volume 2, Issue 1, March 2026.
ABSTRACT Age‐related hearing loss (ARHL) is a degenerative disorder of the auditory system, characterized by bilateral symmetrical sensorineural hearing loss that occurs with aging. As a highly prevalent age‐related condition worldwide, ARHL significantly impairs both the quality of life and mental health of the elderly.
Yu Xiao, Jiaxin Liu, Xiaohan Zhang, Miao Chang, Cheng Cheng, Yunhao Wu, Xiaolong Fu   +6 more
wiley   +1 more source

Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis

Journal of Experimental Pharmacology, 2021
Madalena C Pinto,1,* Iris AL Silva,1,* Miriam F Figueira,2 Margarida D Amaral,1 Miquéias Lopes-Pacheco1,* 1Biosystems & Integrative Sciences Institute (BioISI), Faculty of Sciences, University of Lisboa, Lisboa, Portugal; 2Marsico Lung ...
Pinto MC, Silva IAL, Figueira MF, Amaral MD, Lopes-Pacheco M   +4 more
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