Results 111 to 120 of about 6,153 (212)

Endothelial Dysfunction Following Enhanced TMEM16A Activity in Human Pulmonary Arteries

Cells, 2020
Endothelial dysfunction is one of the hallmarks of different vascular diseases, including pulmonary arterial hypertension (PAH). Ion channelome changes have long been connected to vascular remodeling in PAH, yet only recently has the focus shifted ...
Davor Skofic Maurer, Diana Zabini, Chandran Nagaraj, Neha Sharma, Miklós Lengyel, Bence M. Nagy, Saša Frank, Walter Klepetko, Elisabeth Gschwandtner, Péter Enyedi, Grazyna Kwapiszewska, Horst Olschewski, Andrea Olschewski   +12 more
doaj   +1 more source

Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. [PDF]

, 2016
Gastrointestinal stromal tumors (GIST) arise within the interstitial cell of Cajal (ICC) lineage due to activating KIT/PDGFRA mutations. Both ICC and GIST possess primary cilia (PC), which coordinate PDGFRA and Hedgehog signaling, regulators of ...
Bardsley, Michael R, Burgoyne, Adam M, Chan, Jonathan C, Chmielecki, Juliann, Gao, Fei, Harismendy, Olivier, Kendrick, Michael L, Lee, Tracy E, Leonard, Stephanie Y, Mao, Junhao, Morosini, Deborah, Ordog, Tamas, Ross, Jeffrey S, Shi, Eileen, Sicklick, Jason K, Siena, Martina De, Syed, Sabriya A, Tang, Chih-Min, Wang, Kai   +18 more
core   +2 more sources

Native small airways secrete bicarbonate. [PDF]

, 2014
Since the discovery of Cl(-) impermeability in cystic fibrosis (CF) and the cloning of the responsible channel, CF pathology has been widely attributed to a defect in epithelial Cl(-) transport. However, loss of bicarbonate (HCO3(-)) transport also plays
Quinton, Paul M, Shamsuddin, AKM
core   +1 more source

Mechanism of persistent hyperalgesia in neuropathic pain caused by chronic constriction injury

Neural Regeneration Research, 2019
Transmembrane member 16A (TMEM16A) is involved in many physiological functions, such as epithelial secretion, sensory conduction, nociception, control of neuronal excitability, and regulation of smooth muscle contraction, and may be important in ...
Qin-Yi Chen, Chao-Yang Tan, Yang Wang, Ke-Tao Ma, Li Li, Jun-Qiang Si   +5 more
doaj   +1 more source

TMEM16A blocker as vasorelaxant

, 2013
Background and purposeT16A(inh) -A01 is a recently identified inhibitor of the calcium-activated chloride channel TMEM16A. The aim of this study was to test the efficacy of T16A(inh) -A01 for inhibition of calcium-activated chloride channels in vascular smooth muscle and consequent effects on vascular tone.Experimental approachSingle channel and whole ...
Davis, Alison J, Shi, Jian, Pritchard, Harry AT, Chadha, Preet S, Leblanc, Normand, Vasilikostas, Georgios, Yao, Zhen, Verkman, AS, Albert, Anthony P, Greenwood, Iain A   +9 more
openaire   +2 more sources

Coumarins attenuate intestinal motility by inhibiting TMEM16A.

Die Pharmazie
Transmembrane 16A (TMEM16A) is highly expressed in interstitial cells of Cajal (ICC) and participates in ICC-mediated rhythmic contractile activity of intestinal smooth muscle. TMEM16A is also expressed in epithelium of intestine with a minor contributor to transepithelial fluid secretion, while other unidentified Ca2+ -activated Cl - channels (unCaCCs)
Xiaojuan Zhu, Xiaojuan Zhu, Hao Wang, Hao Wang, Bo Yu, Bo Yu, Lingling Jin, Lingling Jin, Chao Qu, Chao Qu, Hongyan Li, Hongyan Li, Hong Yang, Hong Yang   +6 more
openaire   +2 more sources

Activation and Inhibition of TMEM16A Calcium-Activated Chloride Channels

PLoS ONE, 2014
Calcium-activated chloride channels (CaCC) encoded by family members of transmembrane proteins of unknown function 16 (TMEM16) have recently been intensely studied for functional properties as well as their physiological roles as chloride channels in various tissues. One technical hurdle in studying these channels is the well-known channel rundown that
Ni, Yu-Li, Kuan, Ai-Seon, Chen, Tsung-Yu
openaire   +6 more sources

Mechanisms of CFTR Functional Variants That Impair Regulated Bicarbonate Permeation and Increase Risk for Pancreatitis but Not for Cystic Fibrosis [PDF]

, 2014
CFTR is a dynamically regulated anion channel. Intracellular WNK1-SPAK activation causes CFTR to change permeability and conductance characteristics from a chloride-preferring to bicarbonate-preferring channel through unknown mechanisms.
Alkaade, Samer, Aloe, Amy, Amann, Stephen T., Anderson, Michelle A., Bahar, Ivet, Baillie, John, Banks, Peter A., Barmada, M. Michael, Brand, Randall E., Conwell, Darwin, Cote, Gregory, Gardner, Timothy B., Gelrud, Andres, General, Ignacio, Jung, Jinsei, Kienholz, Michelle L., LaRusch, Jessica, Lawrence, Christopher, Lee, Min Goo, Lewis, Michele D., North American Pancreatitis Study Group, Park, Hyun Woo, Romagnuolo, Joseph, Sandhu, Bimaljit, Slivka, Adam, Whitcomb, David C., Yadav, Dhiraj   +26 more
core   +4 more sources

TMEM16A is associated with Voltage-gated Calcium Channels in mouse retina and its function is disrupted upon mutation of the auxiliary α2δ4 subunit.

Frontiers in Cellular Neuroscience, 2015
Photoreceptors rely upon highly specialized synapses to efficiently transmit signals to multiple postsynaptic targets. Calcium influx in the presynaptic terminal is mediated by voltage-gated calcium channels (VGCC).
Antonella eCaputo, Ilaria ePiano, Gian Carlo eDemontis, Niccolò eBacchi, Simona eCasarosa, Luca eDella Santina, Claudia eGargini   +6 more
doaj   +1 more source

Concurrent absorption and secretion of airway surface liquids and bicarbonate secretion in human bronchioles. [PDF]

, 2019
Although small airways account for the largest fraction of the total conducting airway surfaces, the epithelial fluid and electrolyte transport in small, native airway epithelia has not been well characterized. Investigations have been limited, no doubt,
Quinton, Paul M, Shamsuddin, AKM
core