Results 111 to 120 of about 4,623 (196)

TMEM16A is associated with Voltage-gated Calcium Channels in mouse retina and its function is disrupted upon mutation of the auxiliary α2δ4 subunit.

Frontiers in Cellular Neuroscience, 2015
Photoreceptors rely upon highly specialized synapses to efficiently transmit signals to multiple postsynaptic targets. Calcium influx in the presynaptic terminal is mediated by voltage-gated calcium channels (VGCC).
Antonella eCaputo, Ilaria ePiano, Gian Carlo eDemontis, Niccolò eBacchi, Simona eCasarosa, Luca eDella Santina, Claudia eGargini   +6 more
doaj   +1 more source

Trans-ε-viniferin as an inhibitor of TMEM16A preventing intestinal smooth muscle contraction

, 2023
TMEM16A regulator is an important tool to study the physiological functions and pathogenesis related to TMEM16A. In the present study, trans-ε-viniferin (TV) was identified as a TMEM16A inhibitor with inhibitory activity against TMEM16A mediated Cl ...
Ling-Ling Jin (16882508), Yue Pang (168110), Xin-Yi Liu (221086), Bo Yu (241082), Yan Zhao (58882)   +4 more
core   +1 more source

Activation and Inhibition of TMEM16A Calcium-Activated Chloride Channels

PLoS ONE, 2014
Calcium-activated chloride channels (CaCC) encoded by family members of transmembrane proteins of unknown function 16 (TMEM16) have recently been intensely studied for functional properties as well as their physiological roles as chloride channels in various tissues. One technical hurdle in studying these channels is the well-known channel rundown that
Ni, Yu-Li, Kuan, Ai-Seon, Chen, Tsung-Yu
openaire   +6 more sources

CLCA2 does not increase TMEM16A stability or surface occupancy.

, 2018
(A) Immunofluorescence micrographs showing HEK293 cells stably expressing vector (upper row) or CLCA2 (lower row) and probed for transduced TMEM16A or CLCA2.
Aarushi Sharma (5216615), Grace Ramena (2549773), Louis Premkumar (5216612), Yufang Yin (2549770), Randolph C. Elble (502366)   +4 more
core   +1 more source

Modulation of TMEM16A-Channel Activity as Ca2+ Activated Cl− Conductance via the Interaction With Actin Cytoskeleton in Murine Portal Vein

Journal of Pharmacological Sciences, 2014
.: TMEM16A is a major component of Ca2+-activated Cl− channel (CaCC) conductance in murine portal vein smooth muscle cells (mPVSMCs). Here, the regulation of CaCC activity by the actin cytoskeleton was examined in mPVSMCs.
Junya Ohshiro, Hisao Yamamura, Yoshiaki Suzuki, Yuji Imaizumi   +3 more
doaj   +1 more source

Immunofluorescence labeling of TMEM16A in CRC cell lines.

, 2014
Cells were grown on coverslips and stained with anti-TMEM16A antibodies. Left column, anti-TMEM16A immunofluorescence (Cy3, red). Middle column, DAPI staining to visualize nuclei.
Xuedong Fang (227155), Lili Zhong (679551), Meiyan Sun (679548), Tonghui Ma (549091), Guizhen Zhang (679550), Jinhao Zheng (679553), Yujie Sui (549090), Zhiming Ma (679552), Fei Wu (117860), Weihua Di (679549), Longfei Yang (435484)   +10 more
core   +1 more source

TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis [PDF]

, 2019
Pancreatic cancer typically spreads rapidly and has poor survival rates. Here, we report that the calcium-activated chloride channel TMEM16A is a biomarker for pancreatic cancer with a poor prognosis. TMEM16A is up-regulated in 75% of cases of pancreatic
Lin, Yu-Hsiu T, Jan, Yuh, Wiita, Arun, Gilchrist, John, Gilchrist, John M, Lin, Yu-Hsiu, Crottès, David, Peters, Christian, Peters, Christian J, Jan, Lily, Wiita, Arun P, Jan, Yuh Nung, Jan, Lily Yeh   +12 more
core   +1 more source

TMEM16A Potentiation: Possible Drawbacks

American Journal of Respiratory and Critical Care Medicine, 2020
Andrea Olschewski, Chandran Nagaraj, Diana Zabini, Bence M. Nagy, Grazyna Kwapiszewska, Horst Olschewski   +5 more
openaire   +2 more sources

Data_Sheet_1_Control of Ion Transport by Tmem16a Expressed in Murine Intestine.PDF

, 2019
Cl– secretion by the human and murine intestinal epithelium occurs through the cystic fibrosis transmembrane conductance regulator (cftr). However, the Ca2+ activated Cl– channel Tmem16a was shown to contribute to Cl– secretion, mainly, but not ...
Karl Kunzelmann (80303), Inês Cabrita (7461878), Podchanart Wanitchakool (5821628), Raquel Centeio (7461875), Rainer Schreiber (80302), Kazi Mirajul Hoque (822762), Roberta Benedetto (7461881), Tultul Saha (822761)   +7 more
core   +1 more source

Pharmacological properties of native CaCCs and TMEM16A [PDF]

Channels, 2014
Kenton M, Sanders, Kate, O'Driscoll, Normand, Leblanc   +2 more
openaire   +2 more sources