Results 121 to 130 of about 4,623 (196)

TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression

, 2012
Frequent gene amplification of the receptor-activated calcium-dependent chloride channel TMEM16A (TAOS2 or ANO1) has been reported in several malignancies. However, its involvement in human tumorigenesis has not been previously studied.
Kunzelmann, K, Gollin, SM, Egloff, AM, Grandis, JR, Huang, X, Harfe, BD, Lui, VW, Xiao, D, Chen, X, Schreiber, R, Duvvuri, U, Edinger, RS, Seethala, RS, Shiwarski, DJ, Rock, JR, Bertrand, C, Henson, BJ   +16 more
core   +2 more sources

Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A

Nature Communications, 2019
The calcium-activated chloride channel (CaCC) TMEM16A plays crucial roles in regulating neuronal excitability and muscle contraction. Here authors show that phosphatidylinositol (4,5)-bisphosphate (PIP2) regulates TMEM16A channel activation and ...
Son C. Le, Zhiguang Jia, Jianhan Chen, Huanghe Yang   +3 more
doaj   +1 more source

TMEM16A knockdown induced a decrease in proliferation of SW620 cells.

, 2014
A, The growth of SW620 cells was inhibited by TMEM16A shRNA #1 and #2 compared to the control group (Mean ± SD; n = 3 ...
Xuedong Fang (227155), Lili Zhong (679551), Meiyan Sun (679548), Tonghui Ma (549091), Guizhen Zhang (679550), Jinhao Zheng (679553), Yujie Sui (549090), Zhiming Ma (679552), Fei Wu (117860), Weihua Di (679549), Longfei Yang (435484)   +10 more
core   +1 more source

Olfactory sensory neurons in the developing olfactory epithelium of TMEM16A^-/- and TMEM16A^+/+ mice.

, 2015
Mature olfactory sensory neurons express the olfactory marker protein (OMP). Confocal images of coronal sections of the olfactory epithelium at E14.5, E16.5, E18.5 and P4 from TMEM16A-/- (A, C, E, G) or TMEM16A+/+ (B, D, F, H) mice.
Devendra Kumar Maurya (753367), Anna Menini (266689), Nicoletta Pedemonte (383764), Tiago Henriques (753368), Jason R. Rock (247452), Monica Marini (753369), Brian D. Harfe (148989), Luis J. V. Galietta (753370)   +7 more
core   +1 more source

The Tmem16a chloride channel is required for mucin maturation after secretion from goblet-like cells in the Xenopus tropicalis tadpole skin

Scientific Reports
The TMEM16A chloride channel is proposed as a therapeutic target in cystic fibrosis, where activation of this ion channel might restore airway surface hydration and mitigate respiratory symptoms.
Eamon Dubaissi, Emma N. Hilton, Sarah Lilley, Richard Collins, Charlotte Holt, Peter March, Henry Danahay, Martin Gosling, Richard K Grencis, Ian S Roberts, David J Thornton   +10 more
doaj   +1 more source

Control of TMEM16A by INO‐4995 and other inositolphosphates

, 2013
Background And Purpose Ca2+-dependent Cl- secretion (CaCC) in airways and other tissues is due to activation of the Cl- channel TMEM16A (anoctamin 1).
Fragata, José I, Tian, Yuemin, Kongsuphol, Patthara, Uliyakina, Inna, Faria, Diana, Wanitchakool, Podchanart, Kunzelmann, Karl, Traynor‐Kaplan, Alexis E, Schreiber, Rainer, Sousa, Marisa, Palma, Marta, Amaral, Margarida D   +11 more
core   +1 more source

ANO1 (TMEM16A) Genetic Variants, Promoter Methylation, and Chloride Dysregulation in Pulmonary Hypertension. [PDF]

J Cardiovasc Dev Dis
Yaman İ, Korkmaz H, Akağaç AE, Kaymaz T, Önder R, Önalan EE.   +5 more
europepmc   +1 more source

A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow. [PDF]

Proc Natl Acad Sci U S A
Xiang L, Hariharan A, Isaacs D, Weir N, Longden TA.   +4 more
europepmc   +1 more source

Exploring the selective inhibitory effects of Flavoxate and its analogues on two chloride channels and neuronal action potentials. [PDF]

Korean J Physiol Pharmacol
Zhang G, Zhou A, Liu J, Wang J, Yang J, Cui Y, Zhao Y, Song Y, Li Y, Li H, Zhang X, Zhang Y.   +11 more
europepmc   +1 more source

Interplay of Ca²⁺ and PIP₂ in TMEM16A channel function. [PDF]

J Physiol
Lara-Santos C, Tembo M, Miller JM, Rosenbaum JC, Carlson AE.   +4 more
europepmc   +1 more source