Results 101 to 110 of about 3,802 (167)

Regulation of TMEM16A altrenatice splincing

, 2012
TMEM16A/Anoctamin1 is a novel calcium-­‐activated chloride channel involved in neuronal and cardiac excitation, vascular tone, pain perception and olfactory and sensory signal transduction and GI tract motility. It is also associated to diverse type of cancer including breast cancer malignancy. Alternative splicing (AS) of exons 6b, 13 and 15 generates
openaire   +1 more source

The role and regulation of TMEM16A in the vascular system

, 2019
TMEM16A is a Ca2+-activated Cl- channel (CaCC) encoded by the TMEM16A gene, expressed in vascular smooth muscle cells (VSMCs). TMEM16A has a proposed role in depolarising the membrane potential (Vm) in response to activation of the Gq-protein coupled receptor (Gq-PCR) signalling cascade.
openaire   +1 more source

ANO1 (TMEM16A) Genetic Variants, Promoter Methylation, and Chloride Dysregulation in Pulmonary Hypertension. [PDF]

J Cardiovasc Dev Dis
Yaman İ, Korkmaz H, Akağaç AE, Kaymaz T, Önder R, Önalan EE.   +5 more
europepmc   +1 more source

A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow. [PDF]

Proc Natl Acad Sci U S A
Xiang L, Hariharan A, Isaacs D, Weir N, Longden TA.   +4 more
europepmc   +1 more source

Exploring the selective inhibitory effects of Flavoxate and its analogues on two chloride channels and neuronal action potentials. [PDF]

Korean J Physiol Pharmacol
Zhang G, Zhou A, Liu J, Wang J, Yang J, Cui Y, Zhao Y, Song Y, Li Y, Li H, Zhang X, Zhang Y.   +11 more
europepmc   +1 more source

Interplay of Ca²⁺ and PIP₂ in TMEM16A channel function. [PDF]

J Physiol
Lara-Santos C, Tembo M, Miller JM, Rosenbaum JC, Carlson AE.   +4 more
europepmc   +1 more source

Advances in the Treatment of Autosomal Dominant Polycystic Kidney Disease and Novel Therapeutic Targets. [PDF]

Curr Issues Mol Biol
Zhang W, Sun T, Wang X, Jiang T.
europepmc   +1 more source

Epithelial plasma membrane transporters as drug targets. [PDF]

Physiol Rev
Verkman AS.
europepmc   +1 more source

Carrier-free procyanidin-ferric nanonetworks loading gefitinib to inhibit TMEM16A-EGFR mutual activation loop for photothermally enhanced breast cancer targeted therapy. [PDF]

Mater Today Bio
Li G, Cai C, Zhang N, Wang Z, Zhang M, Liu Q, Chen S, Shang Y, Zhao C, Ren S, An H.   +10 more
europepmc   +1 more source

Restoring chloride efflux in cystic fibrosis with TMEM16a antisense oligonucleotides. [PDF]

Mol Ther
Mitri C, Rousselet N, Bardin P, Dias Wickramanayaka M, Foussignière T, Dupuis G, Leblanc M, Gournet V, Sonneville F, Corvol H, Tabary O.   +10 more
europepmc   +1 more source