Results 101 to 110 of about 6,139 (238)

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 channels to control artery tone and capillary diameter

British Journal of Pharmacology
TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism
Rachel Kaye, Claire F. Pearson, Tibyan Babiker, Emilio Agostinelli, Rumaitha Al-Hosni, Paolo Tammaro   +5 more
semanticscholar   +1 more source

Recent progress in structural studies on TMEM16A channel

Computational and Structural Biotechnology Journal, 2020
The calcium-activated chloride channel, also known as TMEM16A, shows both calcium and membrane potential dependent activation. The channel is expressed broadly and contributes to a variety of physiological processes, and it is expected to be a target for the treatment of diseases such as hypertension, pain, cystic fibrosis and lung cancer.
Sai Shi, Chunli Pang, Shuai Guo, Yafei Chen, Biao Ma, Chang Qu, Qiushuang Ji, Hailong An   +7 more
openaire   +3 more sources

Novel volume‐electron microscopic ultrastructural analysis of gastrointestinal excitability associated with calcium–activated chloride channels

The Journal of Physiology, EarlyView.
Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley   +1 more source

The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia

Journal of Clinical Investigation, 2022
Pericyte-mediated capillary constriction decreases cerebral blood flow in stroke after an occluded artery is unblocked. The determinants of pericyte tone are poorly understood.
Nils Korte, Zeki Ilkan, C. L. Pearson, Thomas Pfeiffer, Prabhav Singhal, J. Rock, H. Sethi, D. Gill, D. Attwell, P. Tammaro   +9 more
semanticscholar   +1 more source

TMEM16A Ca2+‐activated Cl− channel: Functional interactions with cytoskeletal and membrane‐associated proteins

The Journal of Physiology, EarlyView.
Abstract figure legend The calcium‐activated chloride (ClCa) channel TMEM16A (also known as ANO1) plays critical roles in ion transport, neurotransmission and smooth muscle contraction. Dysregulation of TMEM16A channel activity contributes to the development and progression of various diseases.
Hisao Yamamura, Rubii Kondo, Yoshiaki Suzuki, Yuji Imaizumi, Aya Yamamura   +4 more
wiley   +1 more source

CLCA2 and TMEM16A do not directly interact.

, 2018
(A) Immunoblots of cells transfected with CLCA2, TMEM16A, or both. Proteins were immunoprecipitated and detected with antibodies specific for either protein. (B) Cells stably expressing vector or CLCA2 were transiently transfected with TMEM16A (TMEM) and
Aarushi Sharma (5216615), Grace Ramena (2549773), Louis Premkumar (5216612), Yufang Yin (2549770), Randolph C. Elble (502366)   +4 more
core   +1 more source

Ca2+ Dependence of Volume-Regulated VRAC/LRRC8 and TMEM16A Cl– Channels

Frontiers in Cell and Developmental Biology, 2020
All vertebrate cells activate Cl– currents (ICl,swell) when swollen by hypotonic bath solution. The volume-regulated anion channel VRAC has now been identified as LRRC8/SWELL1.
Raquel Centeio, Jiraporn Ousingsawat, Rainer Schreiber, Karl Kunzelmann   +3 more
doaj   +1 more source

Update on cellular expression and function of ANO1 channels in urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley   +1 more source

Extracellular Chloride Regulates TMEM16A Gating [PDF]

Biophysical Journal, 2015
The gating mechanism of TMEM16A, an essential subunit of the Ca2+-activated Cl- channel, remains incompletely understood. Gating of TMEM16A channels is complex because elevation of intracellular calcium concentration ([Ca2+]i), strong depolarizations (Vm), and high extracellular Cl or highly permeant anions seem to contribute.
Contreras-Vite, Juan A., Cruz-Rangel, Silvia, Pérez-Cornejo, Patricia, Hartzell, H. Criss, Arreola, Jorge   +4 more
openaire   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source