Results 101 to 110 of about 4,623 (196)

Intermolecular Interactions in the TMEM16A Dimer Controlling Channel Activity

, 2018
TMEM16A e TMEM16B sono proteine di membrana con funzione di canali del cloruro attivati da calcio. Attraverso la generazione di canali chimerici, e in particolare, sostituendo la regione carbossi-terminale di TMEM16A con la regione equivalente di ...
SCUDIERI, PAOLO
core   +1 more source

Endothelial Dysfunction Following Enhanced TMEM16A Activity in Human Pulmonary Arteries

Cells, 2020
Endothelial dysfunction is one of the hallmarks of different vascular diseases, including pulmonary arterial hypertension (PAH). Ion channelome changes have long been connected to vascular remodeling in PAH, yet only recently has the focus shifted ...
Davor Skofic Maurer, Diana Zabini, Chandran Nagaraj, Neha Sharma, Miklós Lengyel, Bence M. Nagy, Saša Frank, Walter Klepetko, Elisabeth Gschwandtner, Péter Enyedi, Grazyna Kwapiszewska, Horst Olschewski, Andrea Olschewski   +12 more
doaj   +1 more source

Piezo1 in intestinal smooth muscle cells: Emerging perspectives

The Journal of Physiology, Volume 604, Issue 1, Page 129-144, 1 January 2026.
Abstract figure legend Loss of Piezo1 in SMCs results in delayed gut transit, impaired small bowel contractility, and tissue alterations. But more critically, Piezo1 is shown to be intracellularly localized, highlighting important implications given the phenotype. Adapted from Bautista, G.M. et al.
Geoanna M. Bautista, L. Fernando Santana, Martin G. Martin   +2 more
wiley   +1 more source

Upregulation of TMEM16A Protein in Bronchial Epithelial Cells by Bacterial Pyocyanin.

PLoS ONE, 2015
Induction of mucus hypersecretion in the airway epithelium by Th2 cytokines is associated with the expression of TMEM16A, a Ca2+-activated Cl- channel. We asked whether exposure of airway epithelial cells to bacterial components, a condition that mimics ...
Emanuela Caci, Paolo Scudieri, Emma Di Carlo, Patrizia Morelli, Silvia Bruno, Ida De Fino, Alessandra Bragonzi, Ambra Gianotti, Elvira Sondo, Loretta Ferrera, Alessandro Palleschi, Luigi Santambrogio, Roberto Ravazzolo, Luis J V Galietta   +13 more
doaj   +1 more source

Knockdown of TMEM16A in SW620 cells.

, 2014
A, Western blot analysis of TMEM16A protein expression in SW620 cells that were transfected with shRNA #1 and #2. B, The bar graph summarizes the relative expression level of TMEM16A protein from panel A.
Xuedong Fang (227155), Lili Zhong (679551), Meiyan Sun (679548), Tonghui Ma (549091), Guizhen Zhang (679550), Jinhao Zheng (679553), Yujie Sui (549090), Zhiming Ma (679552), Fei Wu (117860), Weihua Di (679549), Longfei Yang (435484)   +10 more
core   +1 more source

Mechanism of persistent hyperalgesia in neuropathic pain caused by chronic constriction injury

Neural Regeneration Research, 2019
Transmembrane member 16A (TMEM16A) is involved in many physiological functions, such as epithelial secretion, sensory conduction, nociception, control of neuronal excitability, and regulation of smooth muscle contraction, and may be important in ...
Qin-Yi Chen, Chao-Yang Tan, Yang Wang, Ke-Tao Ma, Li Li, Jun-Qiang Si   +5 more
doaj   +1 more source

Die Bedeutung des calciumaktivierten Chloridkanals TMEM16A in vaskulären glatten Muskelzellen [PDF]

, 2015
Der arterielle Blutdruck wird durch das Herzzeitvolumen und den peripheren Widerstand des Gefäßsystems bestimmt. Dieser hängt wesentlich vom Tonus kleiner Arteriolen ab, die ihren Durchmesser durch Kontraktion ihrer glatten Muskelzellen verändern können.
Heinze, Christoph
core  

Immunohistochemical detection of TMEM16A in human airways.

, 2015
(A) Expression of TMEM16A in the surface epithelium. TMEM16A staining was mostly absent (b), and sometimes scanty (c) in the respiratory epithelium lining bronchi or bronchioles from CF patients (c, arrows).
Alessandra Bragonzi (108447), Luigi Santambrogio (762699), Roberto Ravazzolo (115170), Ambra Gianotti (762696), Loretta Ferrera (762697), Elvira Sondo (240239), Luis J. V. Galietta (753370), Emanuela Caci (371976), Paolo Scudieri (762694), Ida De Fino (168422), Alessandro Palleschi (762698), Silvia Bruno (762695), Emma Di Carlo (371973), Patrizia Morelli (727995)   +13 more
core   +1 more source

TMEM16A blocker as vasorelaxant

, 2013
Background and purposeT16A(inh) -A01 is a recently identified inhibitor of the calcium-activated chloride channel TMEM16A. The aim of this study was to test the efficacy of T16A(inh) -A01 for inhibition of calcium-activated chloride channels in vascular smooth muscle and consequent effects on vascular tone.Experimental approachSingle channel and whole ...
Davis, Alison J, Shi, Jian, Pritchard, Harry AT, Chadha, Preet S, Leblanc, Normand, Vasilikostas, Georgios, Yao, Zhen, Verkman, AS, Albert, Anthony P, Greenwood, Iain A   +9 more
openaire   +2 more sources

Coumarins attenuate intestinal motility by inhibiting TMEM16A

Die Pharmazie
Transmembrane 16A (TMEM16A) is highly expressed in interstitial cells of Cajal (ICC) and participates in ICC-mediated rhythmic contractile activity of intestinal smooth muscle. TMEM16A is also expressed in epithelium of intestine with a minor contributor to transepithelial fluid secretion, while other unidentified Ca2+ -activated Cl – channels (unCaCCs)
Xiaojuan Zhu, Xiaojuan Zhu, Hao Wang, Hao Wang, Bo Yu, Bo Yu, Lingling Jin, Lingling Jin, Chao Qu, Chao Qu, Hongyan Li, Hongyan Li, Hong Yang, Hong Yang   +6 more
openaire   +2 more sources