Results 81 to 90 of about 6,139 (238)

Microtubule-dependent regulation of TMEM16A-mediated Ca2+-activated Cl- currents in vascular smooth muscle cells.

Journal of Pharmacological Sciences
TMEM16A channels mediate Ca2+-activated Cl- (ClCa) currents in vascular smooth muscle cells (VSMCs), and their activity is influenced by cytoskeletal dynamics.
Ryosuke Hemmi, Akane Suzukawa, M. Fujiwara, Rubii Kondo, Yoshiaki Suzuki, Aya Yamamura, H. Yamamura   +6 more
semanticscholar   +1 more source

Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic PAH [PDF]

, 2019
Our systematic analysis of anion channels and transporters in idiopathic pulmonary arterial hypertension (IPAH) showed marked upregulation of the Cl- channel TMEM16A gene.We hypothesised that TMEM16A overexpression might represent a novel vicious circle ...
Ghanim, Bahil, Klepetko, Walter, Olschewski, Horst, Didiasova, Miroslava, Lengyel, Miklós, Egemnazarov, Bakytbek, Maurer, Davor Skofic, Marsh, Leigh M, Nagy, Bence M, Kovacs, Gabor, Szucs, Peter, Enyedi, Péter, Nagaraj, Chandran, Sharma, Neha, Hrzenjak, Andelko, Sievers, Laura, Papp, Rita, Wygrecka, Malgorzata, Zabini, Diana, Höfler, Gerald, Olschewski, Andrea Judit, Kwapiszewska, Grazyna   +21 more
core   +1 more source

Hypoxia increases the proliferation of brain capillary endothelial cells via upregulation of TMEM16A Ca2+-activated Cl− channels

Journal of Pharmacological Sciences, 2021
The blood–brain barrier (BBB) is mainly formed by brain capillary endothelial cells (BCECs) and is exposed to hypoxic environments under pathological conditions. The effects of hypoxia on the expression and activity of Ca2+-activated Cl− (ClCa) channels,
Takahisa Suzuki, Yoshiaki Suzuki, Kiyofumi Asai, Yuji Imaizumi, Hisao Yamamura   +4 more
doaj   +1 more source

Triggered Calcium Lightning Programs Cochlear Development

Exploration, EarlyView.
Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma, Hai‐Peng Wang, Yu‐Meng Jiang, Ke Lai, Ming‐Xian Li, Zhen Zhang, Li‐Na Gong, Jing‐Wei Lai, Kai‐Ming Su, Lu‐Yang Wang, Hui Wang, Shan‐Kai Yin, Hao He, Hai‐Bo Shi   +13 more
wiley   +1 more source

Sevoflurane reduces brain edema and improves blood-brain barrier by downregulating CaMKII to inhibit TMEM16A after cerebral ischemia injury both in vivo and in vitro.

Brain Research Bulletin
This study aimed to investigate whether sevoflurane could reduce brain edema and protect blood-brain barrier (BBB) after cerebral-ischemia injury in vivo and in vitro via calmodulin-dependent protein kinase II (CaMKII)/ transmembrane protein 16A (TMEM16A)
Jingbin Zhang, Yuhe Tian, Ruixue Wang, Xinlei Qin, Quntao Li, Ketao Ma, Junqiang Si, Dongyu Zhao, Yan Li, Jiang-Wen Yin   +9 more
semanticscholar   +1 more source

Expression of TMEM16A, cytokeratin 8 and ezrin in the olfactory epithelium of TMEM16A^-/- and TMEM16A^+/+ littermate mice.

, 2015
Confocal images of coronal sections of the olfactory epithelium from a region near the transition zone with the respiratory epithelium at E16.5 and P4 from TMEM16A-/- (A, C, E, G) or TMEM16A+/+ (B, D, F, H).
Devendra Kumar Maurya (753367), Anna Menini (266689), Nicoletta Pedemonte (383764), Tiago Henriques (753368), Jason R. Rock (247452), Monica Marini (753369), Brian D. Harfe (148989), Luis J. V. Galietta (753370)   +7 more
core   +1 more source

Non-canonical translation start sites in the TMEM16A chloride channel [PDF]

, 2014
TMEM16A is a plasma membrane protein with voltage- and calcium-dependent chloride channel activity. The role of the various TMEM16A domains in expression and function is poorly known.
Caci, Emanuela, Tomati, Valeria, Scudieri, Paolo, Farrugia, Gianrico, Galietta, Luis J. V., Ravazzolo, Roberto, Mazzone, Amelia, Galietta, Luis J.V., Sondo, Elvira   +8 more
core   +1 more source

Role of ANO1‐Expressing PDGFRα+ Smooth Muscle Cells in Generating Spontaneous Phasic Contractions of the Rodent Epididymis

Andrology, EarlyView.
ABSTRACT Background Spontaneous phasic contractions (SPCs) in the epididymal duct play an important role in transport and maturation of sperm. In proximal cauda of the rat epididymis, platelet‐derived growth factor receptor α (PDGFRα)‐positive smooth muscle cells (SMCs) generate ANO1 Ca2+‐activated chloride channels (CaCCs)‐dependent spontaneous ...
Wataru Kudo, Hiromichi Takano, Toshiya Izuchi, Retsu Mitsui, Kyoko Miwa‐Nishimura, Hikaru Hashitani   +5 more
wiley   +1 more source

TMEM16A inhibition by eugenol.

, 2012
A. Short-circuit current measured in TMEM16A-expressing FRT cells in the presence of a transepithelial Cl− gradient. Indicated concentrations of eugenol were added 10 min prior to TMEM16A activation by 1 µM ionomycin. B.
Jinhong Park (161037), A. S. Verkman (161048), Eun A. Ko (123088), Lukmanee Tradtrantip (161043), Zhen Yao (161023), Wan Namkung (161030)   +5 more
core   +1 more source

Potentiation of TMEM16A Currents by CLCA1 in Cystic Fibrosis Airway [PDF]

, 2021
In the airway, proper activity of the anion channel cystic fibrosis transmembrane conductance regulator (CFTR) contributes to innate immune defense by maintaining a hydratedand alkaline mucus layer through the conductance of chloride and bicarbonate ions.
Berry, Kayla
core   +1 more source