Vasopressin regulates the growth of the biliary epithelium in polycystic liver disease [PDF]
, 2016 The neurohypophysial hormone arginine vasopressin (AVP) acts by three distinct receptor subtypes: V1a, V1b, and V2. In the liver, AVP is involved in ureogenesis, glycogenolysis, neoglucogenesis and regeneration. No data exist about the presence of AVP in
Alpini, Gianfranco +11 more
core +1 more source
Update on cellular expression and function of ANO1 channels in urethral smooth muscle
The Journal of Physiology, EarlyView.Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley +1 more source
Inhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cells. [PDF]
PLoS ONE, 2014 Metastasis leads to poor prognosis in colorectal cancer patients, and there is a growing need for new therapeutic targets. TMEM16A (ANO1, DOG1 or TAOS2) has recently been identified as a calcium-activated chloride channel (CaCC) and is reported to be ...
Yujie Sui +10 more
doaj +1 more source
Epinephrine stimulation of anion secretion in the Calu-3 serous cell model [PDF]
, 2014 Calu-3 is a well-differentiated human bronchial cell line with the characteristics of the serous cells of airway submucosal glands. The submucosal glands play a major role in mucociliary clearance because they secrete electrolytes that facilitate airway ...
Banga, Amiraj +4 more
core +1 more source
Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights
The Journal of Physiology, EarlyView.Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò +18 more
wiley +1 more source
The evolutionary conservation of the core components necessary for the extrinsic apoptotic signaling pathway, in Medaka fish [PDF]
, 2007 [Background]Death receptors on the cell surface and the interacting cytosolic molecules, adaptors and initiator caspases, are essential as core components of the extrinsic apoptotic signaling pathway. While the apoptotic machinery governing the extrinsic
Kazuhiro Sakamaki +3 more
core +2 more sources
Ca2+‐Activated Cl− Channels: Do Bestrophins and TMEM16A Interact?
Acta Physiologica, Volume 242, Issue 6, June 2026.ABSTRACT Aim Ca2+‐activated Cl– conductances are present in many cell types and are important for regulating membrane potential as well as other cellular functions. TMEM16A is widely accepted as the principal molecular basis for Ca2+‐activated Cl– conductances, but also members of the bestrophin family may be important for some Ca2+‐activated Cl ...
Christian Aalkjær +4 more
wiley +1 more source
Ca2+ Dependence of Volume-Regulated VRAC/LRRC8 and TMEM16A Cl– Channels
Frontiers in Cell and Developmental Biology, 2020 All vertebrate cells activate Cl– currents (ICl,swell) when swollen by hypotonic bath solution. The volume-regulated anion channel VRAC has now been identified as LRRC8/SWELL1.
Raquel Centeio +3 more
doaj +1 more source
クラリスロマイシンはモルモット気道上皮細胞のTMEM16A依存性経路を介してIL13誘導杯細胞化生を抑制する [PDF]
, 2018 博士(医学) 甲第664号(主論文の要旨、要約、審査結果の要旨)博士(医学 ...
原 香織
core +1 more source
Cellular Expression Profile for Interstitial Cells of Cajal in Bladder - A Cell Often Misidentified as Myocyte or Myofibroblast [PDF]
, 2012 Background: Interstitial cells of Cajal (ICC) have been identified in urinary bladder of several species, but their presence in mice remains uncertain.
Hill, Warren Gary +2 more
core +2 more sources