Results 141 to 150 of about 6,139 (238)

9‐phenanthrol inhibits TMEM16A channels

The FASEB Journal, 2013
Intravascular pressure stimulates several smooth muscle cell TRP channels, including TRPM4, leading to membrane depolarization and vasoconstriction (the myogenic response). Previous studies using 9‐phenanthrol (9‐phen), a TRPM4 channel inhibitor, suggest that TRPM4 is essential for pressure‐induced depolarization and constriction ...
Sarah Burris, Zachary P. Neeb, Jonathan Jaggar   +2 more
openaire   +1 more source

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways

Frontiers in Pharmacology, 2019
There is an unmet need in severe asthma where approximately 40% of patients exhibit poor β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations.
Kent Miner, Katja Labitzke, Benxian Liu, Paul Wang, Kathryn Henckels, Kevin Gaida, Robin Elliott, Jian Jeffrey Chen, Longbin Liu, Anh Leith, Esther Trueblood, Esther Trueblood, Esther Trueblood, Kelly Hensley, Kelly Hensley, Kelly Hensley, Xing-Zhong Xia, Oliver Homann, Brian Bennett, Mike Fiorino, John Whoriskey, Gang Yu, Sabine Escobar, Min Wong, Teresa L. Born, Alison Budelsky, Mike Comeau, Dirk Smith, Jonathan Phillips, James A. Johnston, Joseph G. McGivern, Kerstin Weikl, David Powers, Karl Kunzelmann, Deanna Mohn, Andreas Hochheimer, John K. Sullivan   +36 more
doaj   +1 more source

CLCA2 does not increase TMEM16A stability or surface occupancy.

, 2018
(A) Immunofluorescence micrographs showing HEK293 cells stably expressing vector (upper row) or CLCA2 (lower row) and probed for transduced TMEM16A or CLCA2.
Aarushi Sharma (5216615), Grace Ramena (2549773), Louis Premkumar (5216612), Yufang Yin (2549770), Randolph C. Elble (502366)   +4 more
core   +1 more source

TMEM16A inhibits renal tubulointerstitial fibrosis via Wnt/β-catenin signaling during hypertension nephropathy.

Cellular Signalling
BACKGROUND AND OBJECTIVE Hypertensive nephropathy is the second leading cause of end-stage renal disease, but its underlying pathogenesis remains unclear.
Feng Wang, Yiqing Zhang, Min Gao, Xuelin Zeng   +3 more
semanticscholar   +1 more source

Immunofluorescence labeling of TMEM16A in CRC cell lines.

, 2014
Cells were grown on coverslips and stained with anti-TMEM16A antibodies. Left column, anti-TMEM16A immunofluorescence (Cy3, red). Middle column, DAPI staining to visualize nuclei.
Xuedong Fang (227155), Lili Zhong (679551), Meiyan Sun (679548), Tonghui Ma (549091), Guizhen Zhang (679550), Jinhao Zheng (679553), Yujie Sui (549090), Zhiming Ma (679552), Fei Wu (117860), Weihua Di (679549), Longfei Yang (435484)   +10 more
core   +1 more source

The physiological roles of anoctamin2/TMEM16B and anoctamin1/TMEM16A in chemical senses.

Cell Calcium
Chemical senses allow animals to detect and discriminate a vast array of molecules. The olfactory system is responsible of the detection of small volatile molecules, while water dissolved molecules are detected by taste buds in the oral cavity. Moreover,
M. Dibattista, S. Pifferi, Andres Hernandez-Clavijo, A. Menini   +3 more
semanticscholar   +1 more source

To "grow" or "go": TMEM16A expression as a switch between tumor growth and metastasis in SCCHN [PDF]

, 2014
PURPOSE: Tumor metastasis is the leading cause of death in patients with cancer. However, the mechanisms that underlie metastatic progression remain unclear.
Bertrand, Carol A, Puthenveedu, Manojkumar A, sano, daisuke, puthenveedu, manojkumar, Shao, Chunbo, duvvuri, umamaheswar, Shao , Chunbo, ha, patrick, Shiwarski, Daniel J, Shiwarski, Daniel, Gaither, Larry, kim, jean, myers, jeffery, Seethala, Raja S, grandis, jennifer, Myers, Jeffery N, Bill, Anke, xiao, dong, bertrand, carol, seethala, raja, Gaither, L Alex   +20 more
core   +1 more source

Data_Sheet_1_Control of Ion Transport by Tmem16a Expressed in Murine Intestine.PDF

, 2019
Cl– secretion by the human and murine intestinal epithelium occurs through the cystic fibrosis transmembrane conductance regulator (cftr). However, the Ca2+ activated Cl– channel Tmem16a was shown to contribute to Cl– secretion, mainly, but not ...
Karl Kunzelmann (80303), Inês Cabrita (7461878), Podchanart Wanitchakool (5821628), Raquel Centeio (7461875), Rainer Schreiber (80302), Kazi Mirajul Hoque (822762), Roberta Benedetto (7461881), Tultul Saha (822761)   +7 more
core   +1 more source

TMEM16A Potentiation: Possible Drawbacks

American Journal of Respiratory and Critical Care Medicine, 2020
Andrea Olschewski, Chandran Nagaraj, Diana Zabini, Bence M. Nagy, Grazyna Kwapiszewska, Horst Olschewski   +5 more
openaire   +2 more sources

Pharmacological properties of native CaCCs and TMEM16A [PDF]

Channels, 2014
Kenton M, Sanders, Kate, O'Driscoll, Normand, Leblanc   +2 more
openaire   +2 more sources