Results 141 to 150 of about 3,802 (167)

Distinct modulation of calcium-activated chloride channel TMEM16A by drug-binding sites. [PDF]

Proc Natl Acad Sci U S A
Roh JW, Gee HY, Wainger B, Kim WK, Lee W, Nam JH.   +5 more
europepmc   +1 more source

TMEM16A ablation in cholinergic medial habenula neurons induces early-onset schizophrenia-like phenotypes in mice. [PDF]

Mol Brain
Kim A, Lee S, Lee S, Kim J, Im HI, Park JY, Hwang EM.   +6 more
europepmc   +1 more source

Human induced pluripotent stem cells for in vitro modeling of impaired mucociliary clearance in cystic fibrosis lung disease. [PDF]

Stem Cell Res Ther
Klassen MC, Balázs A, Zöllner J, Cleve N, Czichon L, von Schledorn L, Hegermann J, Nawroth JC, Roth D, Mielenz M, Hedtfeld S, Stanke F, Rubil T, Ius F, Jonigk D, Hanrahan JW, Ruhparwar A, Olmer R, Mall MA, Merkert S, Martin U.   +20 more
europepmc   +1 more source

TMEM16A Activation Inhibits Autophagy in Dorsal Root Ganglion Cells, Which is Associated with the p38 MAPK/mTOR Pathway. [PDF]

Cell Mol Neurobiol
Yang S, Shang H, Zhang Y, Qiu J, Guo Z, Ma Y, Lan Y, Cui S, Tong H, Li G.   +9 more
europepmc   +1 more source

The multifaceted role of TMEM16A in cancer

Cell Calcium, 2019
The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over decades, TMEM16A over-expression and contribution to prognosis have been widely studied for multiple cancers strengthening the idea that TMEM16A could be a valuable biomarker and a promising therapeutic target.
David Crottès, Lily Jan
exaly   +7 more sources

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Emerging Modulators of TMEM16A and Their Therapeutic Potential

Journal of Membrane Biology, 2021
Calcium-activated chloride channels (CaCCs) are widespread chloride channels which rely on calcium activation to perform their functions. In 2008, TMEM16A (also known as anoctamin1, ANO1) was identified as the molecular basis of the CaCCs, which provided the possibility to study the physiological function of CaCCs.
Xuzhao Wang, Yafei Chen, Hailong An
exaly   +3 more sources

Paving the way for designing drugs targeting TMEM16A

Trends in Pharmacological Sciences, 2021
The calcium-activated chloride channel TMEM16A is involved in several physiological processes and is an important pharmacological target. Dinsdale and colleagues recently unveiled several residues in the outer pore region that constitute a critical site for the design of drugs that modulate TMEM16A channels.
Simone Pifferi, Anna Menini
openaire   +2 more sources

Dysregulation of TMEM16A impairs oviductal transport of embryos

American Journal of Physiology-Cell Physiology, 2023
The ion channel protein TMEM16A is expressed in the epithelium and smooth muscle of the human fallopian tube and is upregulated in patients with tubal pregnancy. TMEM16A is involved in regulating the smooth muscle contraction and the cilia beating. Dysregulated TMEM16A may result in embryo retention in the oviduct and delayed early embryo development.
Nannan Ning, Dan Luo, Wei Xia, Guangjing Mou, Jiangli Zhao, Jian Zhang, Cheng Li, Hongchun Wang, Jingxin Li   +8 more
openaire   +2 more sources

Downregulation of Ca2+-Activated Cl− Channel TMEM16A by the Inhibition of Histone Deacetylase in TMEM16A-Expressing Cancer Cells

The Journal of Pharmacology and Experimental Therapeutics, 2014
The Ca(2+)-activated Cl(-) channel transmembrane proteins with unknown function 16 A (TMEM16A; also known as anoctamin 1 or discovered on gastrointestinal stromal tumor 1) plays an important role in facilitating the cell growth and metastasis of TMEM16A-expressing cancer cells.
Sayo, Matsuba, Satomi, Niwa, Katsuhiko, Muraki, Saki, Kanatsuka, Yurika, Nakazono, Noriyuki, Hatano, Masanori, Fujii, Peng, Zhan, Takayoshi, Suzuki, Susumu, Ohya   +9 more
openaire   +2 more sources