Results 151 to 160 of about 3,802 (167)

TMEM16A (ANO1) as a therapeutic target in cystic fibrosis

Current Opinion in Pharmacology, 2022
Cystic fibrosis (CF) is a multi-organ genetic disease caused by loss of function of CFTR, a cAMP-regulated chloride channel expressed in epithelial cells. In airway epithelia, CFTR-dependent chloride secretion is required to humidify mucosal surface and to allow efficient mucociliary clearance.
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Recent advances in TMEM16A: Structure, function, and disease

Journal of Cellular Physiology, 2018
AbstractTMEM16A (also known as anoctamin 1, ANO1) is the molecular basis of the calcium‐activated chloride channels, with ten transmembrane segments. Recently, atomic structures of the transmembrane domains of mouse TMEM16A (mTMEM16A) were determined by single‐particle electron cryomicroscopy.
Qiushuang Ji, Shuai Guo, Xuzhao Wang, Chunli Pang, Yong Zhan, Yafei Chen, Hailong An   +6 more
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Relationship between TMEM16A/anoctamin 1 and LRRC8A

Pflügers Archiv - European Journal of Physiology, 2016
TMEM16A/anoctamin 1/ANO1 and VRAC/LRRC8 are independent chloride channels activated either by increase in intracellular Ca(2+) or cell swelling, respectively. In previous studies, we observed overlapping properties for both types of channels. (i) TMEM16A/ANO1 and LRRC8 are inhibited by identical compounds, (ii) the volume-regulated anion channel VRAC ...
Roberta, Benedetto, Lalida, Sirianant, Ines, Pankonien, Podchanart, Wanitchakool, Jiraporn, Ousingsawat, Ines, Cabrita, Rainer, Schreiber, Margarida, Amaral, Karl, Kunzelmann   +8 more
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Regulation of ANO1/TMEM16A anion permeability

Pancreatology, 2013
Background/aim: Bicarbonate (HCO3 ) is an important ingredient in many biological fluids including saliva. However, calcium activated chlo ride channels (CaCCs) in salivary gland acinar cells are known to be poorly permeable to HCO3 in most cases. Methods: To elucidate the possibility of ANO1 as a HCO3 channel, anion currents were measured in HEK 293T ...
Jinsei Jung, Joo Hyun Nam, Hyun Woo Park, Uhtaek Oh, Joo-heon Yoon, Min Goo Lee   +5 more
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TMEM16A channels and their role in taste

The Journal of Physiology, 2021
Xi Yue Zhang, Matthew J. Novello
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TMEM16A/B Associated CaCC: Structural and Functional Insights

Protein & Peptide Letters, 2013
Calcium-activated chloride channels (CaCCs) play fundamental roles in numerous physiological processes. Transmembrane proteins 16A and 16B (TMEM16A/B) were identified to be the best molecular identities of CaCCs to date. This makes molecular investigation of CaCCs become possible. This review discusses the latest findings of TMEM16A/B associated CaCCs,
Chunli, Pang, Hongbo, Yuan, Shuxi, Ren, Yafei, Chen, Hailong, An, Yong, Zhan   +5 more
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TMEM16A MODULATORS

2022
COLLINGWOOD STEPHEN, MCCARTHY CLIVE, HARGRAVE JONATHAN DAVID, HAY DUNCAN ALEXANDER, SCHOFIELD THOMAS BEAUREGARD, ELLAM SARAH, BUXTON CRAIG, HABGOOD MATTHEW, INGRAM PETER, MA CHUN YAN, NAPIER SPENCER, SHAIKH ABDUL, SMITH MATTHEW, STIMSON CHRISTOPHER, WALKER EDWARD   +14 more
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TMEM16A Mediates Mucus Production in Human Airway Epithelial Cells

American Journal of Respiratory Cell and Molecular Biology, 2021
Karl Kunzelmann, Rainer Schreiber, Jiraporn Ousingsawat   +2 more
exaly  

TMEM16A MODULATORS

2023
COLLINGWOOD STEPHEN, MCCARTHY CLIVE, HARGRAVE JONATHAN DAVID, HAY DUNCAN ALEXANDER, SCHOFIELD THOMAS BEAUREGARD, ELLAM SARAH, BUXTON CRAIG, HABGOOD MATTHEW, INGRAM PETER, MA CHUN YAN, SHAIKH ABDUL, SMITH MATTHEW, STIMSON CHRISTOPHER, WALKER EDWARD   +13 more
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An outer-pore gate modulates the pharmacology of the TMEM16A channel

Proceedings of the National Academy of Sciences of the United States of America, 2021
Tanadet Pipatpolkai, Phillip J Stansfeld, Emilio Agostinelli   +2 more
exaly