Results 151 to 160 of about 6,139 (238)

Targeting TMEM16A ion channels suppresses airway hyperreactivity, inflammation, and remodeling in an experimental Guinea pig asthma model.

Journal of Pharmacological Sciences
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness, inflammation, and remodeling. Calcium (Ca2+)-activated chloride (Cl-) channels, such as TMEM16A, are inferred to be involved in asthma.
J. Mažerik, E. Gondáš, M. Dohál, L. Smieško, M. Jošková, S. Fraňová, M. Šutovská   +6 more
semanticscholar   +1 more source

p90RSK pathway inhibition synergizes with cisplatin in TMEM16A overexpressing head and neck cancer

BMC Cancer
Head and neck squamous cell carcinoma (HNSCC) constitutes one of the most common types of human cancers and often metastasizes to lymph nodes. Platinum-based chemotherapeutic drugs are commonly used for treatment of a wide range of cancers, including ...
A. Yassin-Kassab, Suman Chatterjee, N. Khan, Nathaniel Wang, V. Sandulache, Eric H-B. Huang, T. Burns, U. Duvvuri   +7 more
semanticscholar   +1 more source

Effect of Calcium Supplementation and TMEM16A Inhibition on Endoplasmic Reticulum Stress Induced by Dental Fluorosis in Mice.

Discover medicine
BACKGROUND Dental fluorosis is a discoloration of the teeth caused by the excessive consumption of fluoride. It represents a distinct manifestation of chronic fluorosis in dental tissues, exerting adverse effects on the human body, particularly on teeth.
Yangyang Yu, Fei Xia, Rong Liu, Ya-Hui Yan, Li Yin   +4 more
semanticscholar   +1 more source

Olfactory sensory neurons in the developing olfactory epithelium of TMEM16A^-/- and TMEM16A^+/+ mice.

, 2015
Mature olfactory sensory neurons express the olfactory marker protein (OMP). Confocal images of coronal sections of the olfactory epithelium at E14.5, E16.5, E18.5 and P4 from TMEM16A-/- (A, C, E, G) or TMEM16A+/+ (B, D, F, H) mice.
Devendra Kumar Maurya (753367), Anna Menini (266689), Nicoletta Pedemonte (383764), Tiago Henriques (753368), Jason R. Rock (247452), Monica Marini (753369), Brian D. Harfe (148989), Luis J. V. Galietta (753370)   +7 more
core   +1 more source

Extracellular glucose and dysfunctional insulin receptor signaling independently upregulate arterial smooth muscle TMEM16A expression

American Journal of Physiology - Cell Physiology
Diabetes alters the function of ion channels responsible for regulating arterial smooth muscle membrane potential, resulting in vasoconstriction. Our prior research demonstrated an elevation of TMEM16A in diabetic arteries.
Somasundaram Raghavan, Masuma Akter Brishti, Angelica K. Bernardelli, Alejandro Mata-Daboin, J. Jaggar, M. Leo   +5 more
semanticscholar   +1 more source

Pt(iv) derivatives of cisplatin and oxaliplatin bearing an EMT-related TMEM16A/COX-2-selective dual inhibitor against colorectal cancer cells HCT116.

RSC Medicinal Chemistry
Colorectal cancer represents the over-expression of TMEM16A and COX-2, offering a promising therapeutic strategy. Two Pt(iv) conjugates derived from Pt(ii) drug (cisplatin or oxaliplatin) and niflumic acid, complexes 1 and 2, were designed and prepared ...
Zhong-Ying Ma, Xiao-Jing Ding, Zhen-Zhen Zhu, Qian Chen, Dong-Bo Wang, Xin Qiao, Jing-Yuan Xu   +6 more
semanticscholar   +1 more source

Control of TMEM16A by INO‐4995 and other inositolphosphates

, 2013
Background And Purpose Ca2+-dependent Cl- secretion (CaCC) in airways and other tissues is due to activation of the Cl- channel TMEM16A (anoctamin 1).
Fragata, José I, Tian, Yuemin, Kongsuphol, Patthara, Uliyakina, Inna, Faria, Diana, Wanitchakool, Podchanart, Kunzelmann, Karl, Traynor‐Kaplan, Alexis E, Schreiber, Rainer, Sousa, Marisa, Palma, Marta, Amaral, Margarida D   +11 more
core   +1 more source

Predicting Mutational Effects on Ca2+-Activated Chloride Conduction of TMEM16A Based on a Simulation Study

Journal of the American Chemical Society
The dysfunction and defects of ion channels are associated with many human diseases, especially for loss-of-function mutations in ion channels such as cystic fibrosis transmembrane conductance regulator mutations in cystic fibrosis.
Yue Zhang, Kang Wu, Yu-Qing Li, Song Wu, A. Warshel, Chen Bai   +5 more
semanticscholar   +1 more source

TMEM16A knockdown induced a decrease in proliferation of SW620 cells.

, 2014
A, The growth of SW620 cells was inhibited by TMEM16A shRNA #1 and #2 compared to the control group (Mean ± SD; n = 3 ...
Xuedong Fang (227155), Lili Zhong (679551), Meiyan Sun (679548), Tonghui Ma (549091), Guizhen Zhang (679550), Jinhao Zheng (679553), Yujie Sui (549090), Zhiming Ma (679552), Fei Wu (117860), Weihua Di (679549), Longfei Yang (435484)   +10 more
core   +1 more source

TMEM16A Induces MAPK and Contributes Directly to Tumorigenesis and Cancer Progression

, 2012
Frequent gene amplification of the receptor-activated calcium-dependent chloride channel TMEM16A (TAOS2 or ANO1) has been reported in several malignancies. However, its involvement in human tumorigenesis has not been previously studied.
Egloff, Ann Marie, Edinger, Robert S., Harfe, Brian D., Shiwarski, Daniel J., Kunzelmann, Karl, Schreiber, Rainer, Chen, Xing, Rock, Jason R., Seethala, Raja S., Gollin, Susanne M., Bertrand, Carol, Huang, Xin, Henson, Brian J., Lui, Vivian W., Duvvuri, Umamaheswar, Grandis, Jennifer R., Xiao, Dong   +16 more
core   +1 more source