Results 161 to 170 of about 6,139 (238)

Intestinal epithelial ion channel TMEM16A deficiency impairs enteroendocrine cell differentiation and epithelial homeostasis and enhances anxiety-like behavior in mice

陆军军医大学学报
Objective Transmembrane member 16A (TMEM16A) is involved in intestinal epithelial ion transport and secretory homeostasis, but its effects on enteroendocrine cell (EEC) function and gut-brain axis-related behaviors remain unclear.
Wang Hao, Sun Meiyan
doaj   +1 more source

TMEM16A inhibits autophagy and promotes the invasion of hypopharyngeal squamous cell carcinoma through mTOR pathway.

Carcinogenesis
Previous studies have indicated that transmembrane protein 16A (TMEM16A) plays a crucial role in the pathogenesis and progression of various tumors by influencing multiple signaling pathways.
Xin Yang, Li-Mei Cui, Zhong-Lu Liu, Yu-Mei Li, Xin-xing Wu, Ru-Xian Tian, C. Jia, Chao Ren, Ya-Kui Mou, Xi-Cheng Song   +9 more
semanticscholar   +1 more source

TMEM16A Activation Inhibits Autophagy in Dorsal Root Ganglion Cells, Which is Associated with the p38 MAPK/mTOR Pathway

Cellular and molecular neurobiology
Transmembrane member 16A (TMEM16A) exhibits a negative correlation with autophagy, though the underlying mechanism remains elusive. This study investigates the mechanism between TMEM16A and autophagy by inducing autophagy in DRG neuronal cells using ...
Shuyun Yang, Hui Shang, Yu-Ruo Zhang, Jing Qiu, Zheyi Guo, Yong Ma, Yuhang Lan, Shao-Yang Cui, Hongshuang Tong, Guocai Li   +9 more
semanticscholar   +1 more source

Loss of Vascular TMEM16A Impairs Cerebral Autoregulation and Exacerbates Ischemia-reperfusion Injury. [PDF]

Transl Stroke Res
Andersen AC, Larsen ID, Melnikova EV, Gernemann M, Skryabin BV, Pedersen TM, Beck HC, Guldbrandsen HØ, Gutierrez E, Aalkjaer C, Postnov DD, Matchkov VV, Hansen LMB.   +12 more
europepmc   +1 more source

Epithelial Chloride and Bicarbonate Transport in Intestinal Barrier Failure: A Molecular Target-Validation Assessment of CFTR and SLC26A3/DRA in Inflammatory Bowel Disease. [PDF]

Int J Mol Sci
Seo Y.
europepmc   +1 more source

TRPV4-driven ATP release activates CFTR through ADORA2B and P2RY2 receptors in the airway epithelium. [PDF]

iScience
Genovese M, De Santis M, Giordano A, Marotta P, Galietta LJV.   +4 more
europepmc   +1 more source

ANO1 (TMEM16A) Genetic Variants, Promoter Methylation, and Chloride Dysregulation in Pulmonary Hypertension. [PDF]

J Cardiovasc Dev Dis
Yaman İ, Korkmaz H, Akağaç AE, Kaymaz T, Önder R, Önalan EE.   +5 more
europepmc   +1 more source

A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow. [PDF]

Proc Natl Acad Sci U S A
Xiang L, Hariharan A, Isaacs D, Weir N, Longden TA.   +4 more
europepmc   +1 more source

Myometrial mechanotransduction and the timing of parturition: ion-channel pathways linking uterine stretch, calcium signaling, and inflammation. [PDF]

Front Physiol
Han X, Wu T, Hu X.
europepmc   +1 more source

Natural Products Targeting Airway Inflammation and Mucus Hypersecretion: Molecular Mechanisms and Therapeutic Potential for Respiratory Health. [PDF]

Nutrients
Lee SG, Lee JH, Kang H.
europepmc   +1 more source