Results 181 to 190 of about 4,623 (196)

The role of Transmembrane Protein 16A (TMEM16A) in pulmonary hypertension

Cardiovascular Pathology, 2023
Transmembrane protein 16A (TMEM16A), a member of the TMEM16 family, is the molecular basis of Ca2+-activated chloride channels (CaCCs) and is involved in a variety of physiological and pathological processes. Previous studies have focused more on respiratory-related diseases and tumors.
Ludong Yuan, Yuting Tang, Leijing Yin, Xiaofang Lin, Zhengyang Luo, Shuxin Wang, Jing Li, Pengfei Liang, Bimei Jiang   +8 more
openaire   +2 more sources

Regulation of ANO1/TMEM16A anion permeability

Pancreatology, 2013
Background/aim: Bicarbonate (HCO3 ) is an important ingredient in many biological fluids including saliva. However, calcium activated chlo ride channels (CaCCs) in salivary gland acinar cells are known to be poorly permeable to HCO3 in most cases. Methods: To elucidate the possibility of ANO1 as a HCO3 channel, anion currents were measured in HEK 293T ...
Jinsei Jung, Joo Hyun Nam, Hyun Woo Park, Uhtaek Oh, Joo-heon Yoon, Min Goo Lee   +5 more
openaire   +1 more source

TMEM16A channels and their role in taste

The Journal of Physiology, 2021
Xi Yue Zhang, Matthew J. Novello
openaire   +2 more sources

TMEM16A/B Associated CaCC: Structural and Functional Insights

Protein & Peptide Letters, 2013
Calcium-activated chloride channels (CaCCs) play fundamental roles in numerous physiological processes. Transmembrane proteins 16A and 16B (TMEM16A/B) were identified to be the best molecular identities of CaCCs to date. This makes molecular investigation of CaCCs become possible. This review discusses the latest findings of TMEM16A/B associated CaCCs,
Chunli, Pang, Hongbo, Yuan, Shuxi, Ren, Yafei, Chen, Hailong, An, Yong, Zhan   +5 more
openaire   +2 more sources

TMEM16A mediates the hypersecretion of mucus induced by Interleukin-13

Experimental Cell Research, 2015
Previous studies showed that the Ca(2+)-activated Cl(-) channel (CaCC) was involved in the pathogenesis of mucus hypersecretion induced by Interleukin-13 (IL-13). However, the mechanisms underlying the process were unknown. Recently, transmembrane protein 16A (TMEM16A) was identified as the channel underlying the CaCC current.
Jiachen, Lin, Youfan, Jiang, Li, Li, Yanan, Liu, Hui, Tang, Depeng, Jiang   +5 more
openaire   +2 more sources

TMEM16A channel upregulation in arterial smooth muscle cells produces vasoconstriction during diabetes

American Journal of Physiology - Heart and Circulatory Physiology, 2021
M Dennis Leo, Wen Yin, Somasundaram Raghavan   +2 more
exaly  

Pharmacological Inhibition and Activation of the Ca2+ Activated Cl− Channel TMEM16A

International Journal of Molecular Sciences, 2020
Raquel Centeio, Inés Cabrita, Roberta Benedetto   +2 more
exaly  

The Role of TMEM16A/ERK/NK-1 Signaling in Dorsal Root Ganglia Neurons in the Development of Neuropathic Pain Induced by Spared Nerve Injury (SNI)

Molecular Neurobiology, 2021
Ketao Ma, Junqiang Si, Ma Ketao
exaly  

TMEM16A expression in cholinergic neurons of the medial habenula mediates anxiety‐related behaviors

EMBO Reports, 2020
Ajung Kim, Oleg Yarishkin, Hyun-Gug Jung   +2 more
exaly  

Recent advances in TMEM16A: Structure, function, and disease

Journal of Cellular Physiology, 2019
Qiushuang Ji, Shuai Guo, Xuzhao Wang
exaly