Results 181 to 190 of about 6,153 (212)

Implicates of PIP5K1α in asthma-related biological processes: insights into mechanisms and therapeutic potential. [PDF]

J Transl Med
Wang SJ, Yuan F, Yin LM.
europepmc   +1 more source

Lack of SLC26A9-mediated chloride secretion causes mucus plugging and severe respiratory distress in neonatal mice. [PDF]

JCI Insight
Millar-Büchner P, Salomon JJ, Duerr J, Spahn S, Anagnostopoulou P, Wagner WL, Wielpütz MO, Groene HJ, Balázs A, Mall MA.   +9 more
europepmc   +1 more source

The multifaceted role of TMEM16A in cancer

Cell Calcium, 2019
The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over decades, TMEM16A over-expression and contribution to prognosis have been widely studied for multiple cancers strengthening the idea that TMEM16A could be a valuable biomarker and a promising therapeutic target.
David Crottès, Lily Y Jan
exaly   +7 more sources

Pharmacological characterization of TMEM16A currents [PDF]

Channels, 2014
Recent studies have shown that transmembrane protein 16 A (TMEM16A) is a subunit of calcium-activated chloride channels (CACCs). Pharmacological agents have been used to probe the functional role of CACCs, however their effect on TMEM16A currents has not been systematically investigated.
Timothy I Webb, Mark A Hollywood, Keith D Thornbury   +2 more
exaly   +3 more sources

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Emerging Modulators of TMEM16A and Their Therapeutic Potential

The Journal of Membrane Biology, 2021
Calcium-activated chloride channels (CaCCs) are widespread chloride channels which rely on calcium activation to perform their functions. In 2008, TMEM16A (also known as anoctamin1, ANO1) was identified as the molecular basis of the CaCCs, which provided the possibility to study the physiological function of CaCCs.
Anqi Hao, Shuai Guo, Sai Shi, Xuzhao Wang, Yong Zhan, Yafei Chen, Hailong An   +6 more
openaire   +2 more sources

Paving the way for designing drugs targeting TMEM16A

Trends in Pharmacological Sciences, 2021
The calcium-activated chloride channel TMEM16A is involved in several physiological processes and is an important pharmacological target. Dinsdale and colleagues recently unveiled several residues in the outer pore region that constitute a critical site for the design of drugs that modulate TMEM16A channels.
Simone Pifferi, Anna Menini
openaire   +2 more sources

Dysregulation of TMEM16A impairs oviductal transport of embryos

American Journal of Physiology-Cell Physiology, 2023
The ion channel protein TMEM16A is expressed in the epithelium and smooth muscle of the human fallopian tube and is upregulated in patients with tubal pregnancy. TMEM16A is involved in regulating the smooth muscle contraction and the cilia beating. Dysregulated TMEM16A may result in embryo retention in the oviduct and delayed early embryo development.
Nannan Ning, Dan Luo, Wei Xia, Guangjing Mou, Jiangli Zhao, Jian Zhang, Cheng Li, Hongchun Wang, Jingxin Li   +8 more
openaire   +2 more sources

An outer-pore gate modulates the pharmacology of the TMEM16A channel [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The TMEM16A calcium-gated chloride channels participate in a range of vital physiological functions. TMEM16A channels are desirable new drug targets as their dysfunction can lead to pathology. In spite of this, their pharmacology is still in its infancy. Gaining insight into the mode of action and binding sites for test compounds
Ria L Dinsdale, Tanadet Pipatpolkai, Emilio Agostinelli   +2 more
exaly   +4 more sources