Results 191 to 200 of about 6,139 (238)

Unravelling the Role of Post-Junctional M2 Muscarinic Receptors in Cholinergic Nerve-Mediated Contractions of Airway Smooth Muscle. [PDF]

Int J Mol Sci
Ghosh S, Alkawadri T, Hollywood MA, Thornbury KD, Sergeant GP.   +4 more
europepmc   +1 more source

The multifaceted role of TMEM16A in cancer [PDF]

Cell Calcium, 2019
The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over decades, TMEM16A over-expression and contribution to prognosis have been widely studied for multiple cancers strengthening the idea that TMEM16A could be a valuable ...
David Crottès, Lily Jan
exaly   +8 more sources

Coumarins attenuate intestinal motility by inhibiting TMEM16A.

Die Pharmazie
Transmembrane 16A (TMEM16A) is highly expressed in interstitial cells of Cajal (ICC) and participates in ICC-mediated rhythmic contractile activity of intestinal smooth muscle. TMEM16A is also expressed in epithelium of intestine with a minor contributor
Xiao-Juan Zhu, Hao Wang, Bo Yu, Lingling Jin, Chao Qu, Hongyan Li, H. Yang   +6 more
semanticscholar   +3 more sources

Pharmacological characterization of TMEM16A currents [PDF]

Channels, 2014
Recent studies have shown that transmembrane protein 16 A (TMEM16A) is a subunit of calcium-activated chloride channels (CACCs). Pharmacological agents have been used to probe the functional role of CACCs, however their effect on TMEM16A currents has not been systematically investigated.
Gerard P Sergeant, Keith Thornbury, Mark Hollywood   +2 more
exaly   +3 more sources

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Emerging Modulators of TMEM16A and Their Therapeutic Potential

The Journal of Membrane Biology, 2021
Calcium-activated chloride channels (CaCCs) are widespread chloride channels which rely on calcium activation to perform their functions. In 2008, TMEM16A (also known as anoctamin1, ANO1) was identified as the molecular basis of the CaCCs, which provided the possibility to study the physiological function of CaCCs.
Anqi Hao, Shuai Guo, Sai Shi, Xuzhao Wang, Yong Zhan, Yafei Chen, Hailong An   +6 more
openaire   +2 more sources

Mucus Release and Airway Constriction by TMEM16A May Worsen Pathology in Inflammatory Lung Disease [PDF]

International Journal of Molecular Sciences, 2021
Activation of the Ca2+ activated Cl- channel TMEM16A is proposed as a treatment in inflammatory airway disease. It is assumed that activation of TMEM16A will induce electrolyte secretion, and thus reduce airway mucus plugging and improve mucociliary ...
Karl Kunzelmann, Rainer Schreiber, Tereza Dousova   +2 more
exaly   +2 more sources

Paving the way for designing drugs targeting TMEM16A

Trends in Pharmacological Sciences, 2021
The calcium-activated chloride channel TMEM16A is involved in several physiological processes and is an important pharmacological target. Dinsdale and colleagues recently unveiled several residues in the outer pore region that constitute a critical site for the design of drugs that modulate TMEM16A channels.
Simone Pifferi, Anna Menini
openaire   +2 more sources

Dysregulation of TMEM16A impairs oviductal transport of embryos

American Journal of Physiology-Cell Physiology, 2023
The ion channel protein TMEM16A is expressed in the epithelium and smooth muscle of the human fallopian tube and is upregulated in patients with tubal pregnancy. TMEM16A is involved in regulating the smooth muscle contraction and the cilia beating. Dysregulated TMEM16A may result in embryo retention in the oviduct and delayed early embryo development.
Nannan Ning, Dan Luo, Wei Xia, Guangjing Mou, Jiangli Zhao, Jian Zhang, Cheng Li, Hongchun Wang, Jingxin Li   +8 more
openaire   +2 more sources

Downregulation of Ca2+-Activated Cl− Channel TMEM16A by the Inhibition of Histone Deacetylase in TMEM16A-Expressing Cancer Cells

The Journal of Pharmacology and Experimental Therapeutics, 2014
The Ca(2+)-activated Cl(-) channel transmembrane proteins with unknown function 16 A (TMEM16A; also known as anoctamin 1 or discovered on gastrointestinal stromal tumor 1) plays an important role in facilitating the cell growth and metastasis of TMEM16A-expressing cancer cells.
Sayo, Matsuba, Satomi, Niwa, Katsuhiko, Muraki, Saki, Kanatsuka, Yurika, Nakazono, Noriyuki, Hatano, Masanori, Fujii, Peng, Zhan, Takayoshi, Suzuki, Susumu, Ohya   +9 more
openaire   +2 more sources

TMEM16A Channel Blockade and Strontium/ROS Regulation by Carrier‐Free Nanoprodrug to Reconstruct Bone Homeostasis for Enhanced Osteoporosis Prevention and Treatment

Advanced Functional Materials
Osteoporosis is a prevalent bone disorder caused by an imbalance between bone resorption and formation, leading to bone loss and increased fracture risk.
Donghong Shi, Meng Tian, Yuling Li, Binghao Wang, Chang Qu, Xinyue Shao, Xiaoling Zhao, Jinping Wang, Hailong An   +8 more
semanticscholar   +1 more source