Results 211 to 220 of about 6,139 (238)

Insights into the function and regulation of the calcium-activated chloride channel TMEM16A.

Cell Calcium
The TMEM16A channel, a member of the TMEM16 protein family comprising chloride (Cl-) channels and lipid scramblases, is activated by the free intracellular Ca2+ increments produced by inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release after GqPCRs ...
Jorge Arreola, Ana E López-Romero, Miriam Huerta, M. Guzmán-Hernández, P. Pérez-Cornejo   +4 more
semanticscholar   +1 more source

TMEM16A/B Associated CaCC: Structural and Functional Insights

Protein & Peptide Letters, 2013
Calcium-activated chloride channels (CaCCs) play fundamental roles in numerous physiological processes. Transmembrane proteins 16A and 16B (TMEM16A/B) were identified to be the best molecular identities of CaCCs to date. This makes molecular investigation of CaCCs become possible. This review discusses the latest findings of TMEM16A/B associated CaCCs,
Chunli, Pang, Hongbo, Yuan, Shuxi, Ren, Yafei, Chen, Hailong, An, Yong, Zhan   +5 more
openaire   +2 more sources

Inhibition of TMEM16A impedes embryo implantation and decidualization in mice

Reproduction, 2018
Abstract Recent studies revealed that TMEM16A is involved in several reproductive processes, including ovarian estrogen secretion and ovulation, sperm motility and acrosome reaction, fertilization and myometrium contraction.
Qianrong, Qi, Yifan, Yang, Kailin, Wu, Qingzhen, Xie   +3 more
openaire   +2 more sources

Distinct modulation of calcium-activated chloride channel TMEM16A by drug-binding sites

Proceedings of the National Academy of Sciences of the United States of America
Significance TMEM16A is a calcium-activated chloride channel critical for normal physiology, including blood vessel function and fluid transport in the body. It has emerged as a promising target for treating diseases like hypertension, stroke, and cystic
J. Roh, H. Gee, B. Wainger, W. K. Kim, Wook Lee, Joo-Hyun Nam   +5 more
semanticscholar   +1 more source

Structural and theoretical basis for drug development targeting TMEM16A: Inhibition mechanism of tracheloside analogs.

International Journal of Biological Macromolecules
Ion channels play a crucial role in the electrophysiological activities of organisms. The calcium-activated chloride channel TMEM16A is involved in various physiological processes.
Xiaomeng Guo, Ruili Geng, Chao Li, Zhouye Ma, Yue Chen, Yi-Nuo Liu, Shaochun Li, Xianjiang Kang, Shuai Guo   +8 more
semanticscholar   +1 more source

TMEM16A regulates satellite cell mediated skeletal muscle regeneration by ensuring a moderate level of caspase 3 activity.

Stem Cells
It has been documented that caspase 3 activity is necessary for skeletal muscle regeneration, but how its activity is regulated is largely unknown. Our previous report shows that intracellular TMEM16A, a calcium activated chloride channel, significantly ...
Zhiyuan Sun, Xinqi Shan, C. Fan, Lu-Tao Liu, Shuai Li, Jiahui Wang, Na Zhou, Minsheng Zhu, Hua-Qun Chen   +8 more
semanticscholar   +1 more source

The diverse roles of TMEM16A Ca-activated Cl channels in inflammation

Journal of Advanced Research, 2021
Qinghuan Xiao, Weiliang Bai
exaly  

TMEM16A MODULATORS

2022
COLLINGWOOD STEPHEN, MCCARTHY CLIVE, HARGRAVE JONATHAN DAVID, HAY DUNCAN ALEXANDER, SCHOFIELD THOMAS BEAUREGARD, ELLAM SARAH, BUXTON CRAIG, HABGOOD MATTHEW, INGRAM PETER, MA CHUN YAN, NAPIER SPENCER, SHAIKH ABDUL, SMITH MATTHEW, STIMSON CHRISTOPHER, WALKER EDWARD   +14 more
openaire   +2 more sources

TMEM16A channel upregulation in arterial smooth muscle cells produces vasoconstriction during diabetes

American Journal of Physiology - Heart and Circulatory Physiology, 2021
Dennis Leo, Somasundaram Raghavan, Jonathan H Jaggar   +2 more
exaly  

Ca-activated Cl channel TMEM16A inhibition by cholesterol promotes angiogenesis in endothelial cells

Journal of Advanced Research, 2021
Qinghuan Xiao
exaly