Results 131 to 140 of about 6,139 (238)

Mechanism of persistent hyperalgesia in neuropathic pain caused by chronic constriction injury

Neural Regeneration Research, 2019
Transmembrane member 16A (TMEM16A) is involved in many physiological functions, such as epithelial secretion, sensory conduction, nociception, control of neuronal excitability, and regulation of smooth muscle contraction, and may be important in ...
Qin-Yi Chen, Chao-Yang Tan, Yang Wang, Ke-Tao Ma, Li Li, Jun-Qiang Si   +5 more
doaj   +1 more source

Tamsulosin ameliorates bone loss by inhibiting the release of Cl− through wedging into an allosteric site of TMEM16A

Proceedings of the National Academy of Sciences of the United States of America
Significance With the global population aging at an increasing rate, osteoporosis is emerging as a progressively significant public health concern. TMEM16A is an important target for osteoporosis, however, the development of potent inhibitors remains ...
Shiliang Li, Weijia Sun, Shuang Li, Lili Zhu, Shuai Guo, Jiaqi He, Yuheng Li, Chaoquan Tian, Zhen-Jiang Zhao, Tao Yu, Jianwei Li, Yiqing Zhang, Youlong Hai, Jia-Wen Wang, Yong-Jun Zheng, Rui Wang, Xiaoyong Hu, Shu-Kuan Ling, Hong-Lin Li, Yingxian Li   +19 more
semanticscholar   +1 more source

Immunohistochemical detection of TMEM16A in human airways.

, 2015
(A) Expression of TMEM16A in the surface epithelium. TMEM16A staining was mostly absent (b), and sometimes scanty (c) in the respiratory epithelium lining bronchi or bronchioles from CF patients (c, arrows).
Alessandra Bragonzi (108447), Luigi Santambrogio (762699), Roberto Ravazzolo (115170), Ambra Gianotti (762696), Loretta Ferrera (762697), Elvira Sondo (240239), Luis J. V. Galietta (753370), Emanuela Caci (371976), Paolo Scudieri (762694), Ida De Fino (168422), Alessandro Palleschi (762698), Silvia Bruno (762695), Emma Di Carlo (371973), Patrizia Morelli (727995)   +13 more
core   +1 more source

TMEM16A is associated with Voltage-gated Calcium Channels in mouse retina and its function is disrupted upon mutation of the auxiliary α2δ4 subunit.

Frontiers in Cellular Neuroscience, 2015
Photoreceptors rely upon highly specialized synapses to efficiently transmit signals to multiple postsynaptic targets. Calcium influx in the presynaptic terminal is mediated by voltage-gated calcium channels (VGCC).
Antonella eCaputo, Ilaria ePiano, Gian Carlo eDemontis, Niccolò eBacchi, Simona eCasarosa, Luca eDella Santina, Claudia eGargini   +6 more
doaj   +1 more source

Die Bedeutung des calciumaktivierten Chloridkanals TMEM16A in vaskulären glatten Muskelzellen [PDF]

, 2015
Der arterielle Blutdruck wird durch das Herzzeitvolumen und den peripheren Widerstand des Gefäßsystems bestimmt. Dieser hängt wesentlich vom Tonus kleiner Arteriolen ab, die ihren Durchmesser durch Kontraktion ihrer glatten Muskelzellen verändern können.
Heinze, Christoph
core  

Knockdown of TMEM16A in SW620 cells.

, 2014
A, Western blot analysis of TMEM16A protein expression in SW620 cells that were transfected with shRNA #1 and #2. B, The bar graph summarizes the relative expression level of TMEM16A protein from panel A.
Xuedong Fang (227155), Lili Zhong (679551), Meiyan Sun (679548), Tonghui Ma (549091), Guizhen Zhang (679550), Jinhao Zheng (679553), Yujie Sui (549090), Zhiming Ma (679552), Fei Wu (117860), Weihua Di (679549), Longfei Yang (435484)   +10 more
core   +1 more source

Modulation of TMEM16A-Channel Activity as Ca2+ Activated Cl− Conductance via the Interaction With Actin Cytoskeleton in Murine Portal Vein

Journal of Pharmacological Sciences, 2014
.: TMEM16A is a major component of Ca2+-activated Cl− channel (CaCC) conductance in murine portal vein smooth muscle cells (mPVSMCs). Here, the regulation of CaCC activity by the actin cytoskeleton was examined in mPVSMCs.
Junya Ohshiro, Hisao Yamamura, Yoshiaki Suzuki, Yuji Imaizumi   +3 more
doaj   +1 more source

TMEM16A in smooth muscle cells acts as a pacemaker channel in the internal anal sphincter

Communications Biology
Maintenance of fecal continence requires a continuous or basal tone of the internal anal sphincter (IAS). Paradoxically, the basal tone results largely from high-frequency rhythmic contractions of the IAS smooth muscle.
Ping Lu, Lawrence M. Lifshitz, Karl Bellve, R. Zhuge   +3 more
semanticscholar   +1 more source

TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis [PDF]

, 2019
Pancreatic cancer typically spreads rapidly and has poor survival rates. Here, we report that the calcium-activated chloride channel TMEM16A is a biomarker for pancreatic cancer with a poor prognosis. TMEM16A is up-regulated in 75% of cases of pancreatic
Lin, Yu-Hsiu T, Jan, Yuh, Wiita, Arun, Gilchrist, John, Gilchrist, John M, Lin, Yu-Hsiu, Crottès, David, Peters, Christian, Peters, Christian J, Jan, Lily, Wiita, Arun P, Jan, Yuh Nung, Jan, Lily Yeh   +12 more
core   +1 more source

TMEM16A blocker as vasorelaxant

, 2013
Background and purposeT16A(inh) -A01 is a recently identified inhibitor of the calcium-activated chloride channel TMEM16A. The aim of this study was to test the efficacy of T16A(inh) -A01 for inhibition of calcium-activated chloride channels in vascular smooth muscle and consequent effects on vascular tone.Experimental approachSingle channel and whole ...
Davis, Alison J, Shi, Jian, Pritchard, Harry AT, Chadha, Preet S, Leblanc, Normand, Vasilikostas, Georgios, Yao, Zhen, Verkman, AS, Albert, Anthony P, Greenwood, Iain A   +9 more
openaire   +2 more sources