Results 131 to 140 of about 6,153 (212)

ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling [PDF]

, 2019
Upon membrane depolarization, the KCNQ1 potassium channel opens at the intermediate (IO) and activated (AO) states of the stepwise voltage-sensing domain (VSD) activation. In the heart, KCNQ1 associates with KCNE1 subunits to form
Cui, Jianmin, Gao, Yuan, Hou, Panpan, Shi, Jingyi, White, Kelli McFarland   +4 more
core   +1 more source

Regulation of TMEM16A altrenatice splincing

, 2012
TMEM16A/Anoctamin1 is a novel calcium-­‐activated chloride channel involved in neuronal and cardiac excitation, vascular tone, pain perception and olfactory and sensory signal transduction and GI tract motility. It is also associated to diverse type of cancer including breast cancer malignancy. Alternative splicing (AS) of exons 6b, 13 and 15 generates
openaire   +1 more source

9-Anthracene carboxylic acid is more suitable than DIDS for characterization of calcium-activated chloride current during canine ventricular action potential [PDF]

, 2020
Bányász, Tamás, Hegyi, Bence, Horváth, Balázs, Kistamás, Kornél, Magyar, János, Nánási, Péter Pál, Ruzsnavszky, Ferenc, Szentandrássy, Norbert, Váczi, Krisztina   +8 more
core   +1 more source

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity. [PDF]

, 2019
Deletion of phenylalanine 508 (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel is the most frequent mutation causing cystic fibrosis (CF). F508del-CFTR is misfolded and prematurely degraded. Recently thymosin a-1 (
Armirotti, Andrea, Braccia, Clarissa, Cholon, Deborah M, Galietta, Luis JV, Gentzsch, Martina, Guidone, Daniela, Hanrahan, John W, Lukacs, Gergely L, Matthes, Elizabeth, Pedemonte, Nicoletta, Phuan, Puay-Wah, Tomati, Valeria, Veit, Guido, Verkman, Alan S   +13 more
core  

The role and regulation of TMEM16A in the vascular system

, 2019
TMEM16A is a Ca2+-activated Cl- channel (CaCC) encoded by the TMEM16A gene, expressed in vascular smooth muscle cells (VSMCs). TMEM16A has a proposed role in depolarising the membrane potential (Vm) in response to activation of the Gq-protein coupled receptor (Gq-PCR) signalling cascade.
openaire   +1 more source

Ca2+/calmodulin/MLCK pathway initiates, and RhoA/ROCK maintains, the internal anal sphincter smooth muscle tone. [PDF]

, 2016
Rattan, Satish
core   +2 more sources

Exploring the selective inhibitory effects of Flavoxate and its analogues on two chloride channels and neuronal action potentials. [PDF]

Korean J Physiol Pharmacol
Zhang G, Zhou A, Liu J, Wang J, Yang J, Cui Y, Zhao Y, Song Y, Li Y, Li H, Zhang X, Zhang Y.   +11 more
europepmc   +1 more source

Interplay of Ca²⁺ and PIP₂ in TMEM16A channel function. [PDF]

J Physiol
Lara-Santos C, Tembo M, Miller JM, Rosenbaum JC, Carlson AE.   +4 more
europepmc   +1 more source

Epithelial plasma membrane transporters as drug targets. [PDF]

Physiol Rev
Verkman AS.
europepmc   +1 more source

Carrier-free procyanidin-ferric nanonetworks loading gefitinib to inhibit TMEM16A-EGFR mutual activation loop for photothermally enhanced breast cancer targeted therapy. [PDF]

Mater Today Bio
Li G, Cai C, Zhang N, Wang Z, Zhang M, Liu Q, Chen S, Shang Y, Zhao C, Ren S, An H.   +10 more
europepmc   +1 more source