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International Journal for Parasitology: Drugs and Drug Resistance, 2016 Praziquantel (PZQ) is effectively the only drug currently available for treatment and control of schistosomiasis, a disease affecting hundreds of millions of people worldwide.
Swarna Bais, Robert M. Greenberg
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Role of Chemosensory TRP Channels in Lung Cancer [PDF]
Pharmaceuticals, 2018 Transient receptor potential (TRP) channels represent a large family of cation channels and many members of the TRP family have been shown to act as polymodal receptor molecules for irritative or potentially harmful substances.
Thomas R. H. Büch +4 more
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The Role of Membrane Lipids in Light-Activation of Drosophila TRP Channels
Biomolecules, 2022 Transient Receptor Potential (TRP) channels constitute a large superfamily of polymodal channel proteins with diverse roles in many physiological and sensory systems that function both as ionotropic and metabotropic receptors.
Rita Gutorov +5 more
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Schistosome TRP channels: An appraisal
International Journal for Parasitology: Drugs and Drug Resistance, 2020 Ion channels underlie electrical excitability in cells and are essential for a variety of functions, most notably neuromuscular and sensory activity. They are also validated targets for a preponderance of approved anthelmintic compounds.
Swarna Bais, Robert M. Greenberg
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mSphere, 2023 Transient receptor potential (TRP) channels are evolutionarily conserved integral membrane proteins. They serve as crucial mediators of sensory signals and have profound effects on cellular functions.
Hongchen Wang +3 more
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Functional Importance of Transient Receptor Potential (TRP) Channels in Neurological Disorders
Frontiers in Cell and Developmental Biology, 2021 Transient receptor potential (TRP) channels are transmembrane protein complexes that play important roles in the physiology and pathophysiology of both the central nervous system (CNS) and the peripheral nerve system (PNS).
Kihwan Lee +5 more
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Nociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain Pathologies
Pharmaceuticals, 2016 Specialized receptors belonging to the transient receptor potential (TRP) family of ligand-gated ion channels constitute the critical detectors and transducers of pain-causing stimuli.
Aaron D. Mickle +2 more
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Pharmaceuticals, 2023 Itch (pruritus) is a sensation in the skin that provokes the desire to scratch. The sensation of itch is mediated through a subclass of primary afferent sensory neurons, termed pruriceptors, which express molecular receptors that are activated by itch ...
Merab G. Tsagareli +3 more
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Involvement of Neural Transient Receptor Potential Channels in Peripheral Inflammation
Frontiers in Immunology, 2020 Transient receptor potential (TRP) channels are a superfamily of non-selective cation channels that act as polymodal sensors in many tissues throughout mammalian organisms.
Harold A. Silverman +11 more
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The role of transient receptor potential channels in joint diseases [PDF]
European Cells & Materials, 2017 ransient receptor potential channels (TRP channels) are cation selective transmembrane receptors with diverse structures, activation mechanisms and physiological functions.
O Krupkova, J Zvick, K Wuertz-Kozak
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