Results 1 to 10 of about 31,931 (110)
TRP Channels in Cancer: Signaling Mechanisms and Translational Approaches [PDF]
Biomolecules, 2023 Ion channels play a crucial role in a wide range of biological processes, including cell cycle regulation and cancer progression. In particular, the transient receptor potential (TRP) family of channels has emerged as a promising therapeutic target due ...
Matilde Marini +5 more
doaj +4 more sources
Function of TRP channels in monocytes/macrophages [PDF]
Frontiers in Immunology, 2023 The transient receptor potential channel (TRP channel) family is a kind of non- specific cation channel widely distributed in various tissues and organs of the human body, including the respiratory system, cardiovascular system, immune system, etc.
Jiangbo Wu +33 more
doaj +2 more sources
Acta Pharmaceutica Sinica B, 2022 Transient receptor potential (TRP) channels are one primary type of calcium (Ca2+) permeable channels, and those relevant transmembrane and intracellular TRP channels were previously thought to be mainly associated with the regulation of cardiovascular ...
Tiecheng Zhong +7 more
doaj +3 more sources
TRP channels and breast cancer: the role of TRPs in the pathophysiological development [PDF]
Frontiers in Molecular BiosciencesTRP channels play important roles in regulating various physiological and pathological processes, including the progression of cancer. Several TRP channels mediate tumour development.
Yu Zhang +4 more
doaj +2 more sources
A Comprehensive Review on the Regulatory Action of TRP Channels: A Potential Therapeutic Target for Nociceptive Pain [PDF]
Neuroscience Insights, 2023 The transient receptor potential (TRP) superfamily of ion channels in humans comprises voltage-gated, non-selective cation channels expressed both in excitable as well as non-excitable cells. Four TRP channel subunits associate to create functional homo-
Santosh Anand, Senthilkumar Rajagopal
doaj +2 more sources
TRP channels: Role in neurodegenerative diseases and therapeutic targets [PDF]
Heliyon, 2023 TRP (Transient receptor potential) channels are integral membrane proteins consisting of a superfamily of cation channels that allow permeability of both monovalent and divalent cations. TRP channels are subdivided into six subfamilies: TRPC, TRPV, TRPM,
Mashoque Ahmad Rather +6 more
doaj +2 more sources
Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms [PDF]
Frontiers in Molecular Neuroscience, 2023 Transient receptor potential (TRP) channels are a large and diverse family of transmembrane ion channels that are widely expressed, have important physiological roles, and are associated with many human diseases.
Jian Huang +3 more
doaj +2 more sources
Role of transient receptor potential (TRP) channels in osteoarthritis: a comprehensive review [PDF]
Frontiers in PharmacologyOsteoarthritis (OA) is a chronic degenerative joint disease, primarily characterized by the degeneration of articular cartilage, synovial inflammation, and persistent pain, which severely impairs the quality of life for hundreds of millions of patients ...
Pengyan Qiao +9 more
doaj +2 more sources
TRP Channels in Human Prostate
The Scientific World Journal, 2010 This review gives an overview of morphological and functional characteristics in the human prostate. It will focus on the current knowledge about transient receptor potential (TRP) channels expressed in the human prostate, and their putative role in ...
Carl Van Haute +2 more
doaj +2 more sources
Current Research in Physiology, 2021 Members of the transient receptor potential (TRP) channels that are expressed in the kidney have gained prominence in recent years following discoveries of their role in maintaining the integrity of the filtration barrier, regulating tubular reabsorption
Praghalathan Kanthakumar +1 more
doaj +1 more source