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Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. [PDF]
PLoS ONE, 2011 Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic ...
Andreas Binder +21 more
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Transient receptor potential V1 regulates activation and modulation of transient receptor potential A1 by Ca2+ [PDF]
Neuroscience, 2010 The transient receptor potential A1 (TRPA1) channel contributes to nociceptive signaling in certain pain models. It has been suggested that Ca(2+), which activates and modulates TRPA1, could play a critical regulatory role in this process. Since TRPA1 and transient receptor potential V1 (TRPV1) channels are co-expressed and interact in neurons, we ...
M J, Patil, N A, Jeske, A N, Akopian
exaly +3 more sources
Molecular Pain, 2017 Transient Receptor Potential Vanilloid 1 (TRPV1) and Transient Receptor Potential Ankyrin 1 (TRPA1) expressed mainly by primary sensory neurons function as major nociceptive integrators.
Noémi Bohonyi +11 more
doaj +2 more sources
Transient receptor potential channels meet phosphoinositides [PDF]
EMBO Journal, 2008 Transient receptor potential (TRP) cation channels are unique cellular sensors that are involved in multiple cellular functions, ranging from transduction of sensory signals to the regulation of Ca(2+) and Mg(2+) homoeostasis. Malfunctioning of TRP channels is now recognized as the cause of several hereditary and acquired human diseases. At the time of
Bernd Nilius +2 more
exaly +4 more sources
Changes in transient receptor potential vanilloid 1 and transient receptor potential vanilloid 4 in patients with lower urinary tract dysfunction [PDF]
Investigative and Clinical Urology, 2022 Purpose: We investigated the association between transient receptor potential vanilloid (TRPV) expression in human urothelium tissue and lower urinary tract dysfunction (LUTD).
Kang Jun Cho +5 more
doaj +1 more source
TRPM4 and TRPV2 are two novel prognostic biomarkers and promising targeted therapy in UVM
Frontiers in Molecular Biosciences, 2022 Uveal melanoma (UVM) is the most common primary intraocular malignancy tumor in adults. Almost 50% of UVM patients develop metastatic disease, and is usually fatal within 1 year. However, the mechanism of etiology remains unclear. The lack of prognostic,
Jiong Wang +7 more
doaj +1 more source
Materials Today Advances, 2023 Reactive oxygen species (ROS) play an important role in regulating various physiological functions by activating specific ion channels to mediate cell growth, proliferation, regeneration, and apoptosis.
Boying Li +7 more
doaj +1 more source
Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology
Frontiers in Physiology, 2021 The transient receptor potential (TRP) channels have been described in almost every mammalian cell type. Several members of the Vanilloid (TRPV) subtype have been found to play important roles in modulating cardiac structure and function through Ca2 ...
Michael Miller +6 more
doaj +1 more source
Frontiers in Physiology, 2020 Transient receptor potential canonical 6 (TRPC6) channels are non-selective cation channels that are thought to underlie mechano-modulation of calcium signaling in cardiomyocytes.
Azmi A. Ahmad +6 more
doaj +1 more source
Transient Receptor Potential Channels and Itch
International Journal of Molecular Sciences, 2022 Transient Receptor Potential (TRP) channels are multifunctional sensory molecules that are abundant in the skin and are involved in the sensory pathways of itch, pain, and inflammation. In this review article, we explore the complex physiology of different TRP channels, their role in modulating itch sensation, and their contributions to the ...
Mahmoud, Omar +2 more
openaire +2 more sources