Results 1 to 10 of about 10,401,010 (296)

Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. [PDF]

PLoS ONE, 2011
Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic ...
Andreas Binder, Denisa May, Ralf Baron, Christoph Maier, Thomas R Tölle, Rolf-Detlef Treede, Achim Berthele, Frank Faltraco, Herta Flor, Janne Gierthmühlen, Sierk Haenisch, Volker Huge, Walter Magerl, Christian Maihöfner, Helmut Richter, Roman Rolke, Andrea Scherens, Nurcan Uçeyler, Mike Ufer, Gunnar Wasner, Jihong Zhu, Ingolf Cascorbi   +21 more
doaj   +6 more sources

Transient receptor potential channels meet phosphoinositides [PDF]

EMBO Journal, 2008
Transient receptor potential (TRP) cation channels are unique cellular sensors that are involved in multiple cellular functions, ranging from transduction of sensory signals to the regulation of Ca(2+) and Mg(2+) homoeostasis. Malfunctioning of TRP channels is now recognized as the cause of several hereditary and acquired human diseases. At the time of
Thomas Voets, Bernd Nilius, Grzegorz Owsianik   +2 more
exaly   +4 more sources

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians [PDF]

FEBS Open Bio
Sensing environmental temperature is a complex process involving an array of channels expressed by nociceptive sensory neurons but is critical to allow animals to move away from suboptimal environments and find environments with ideal temperatures ...
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
doaj   +2 more sources

Local upregulation of transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 ion channels in rectosigmoid deep infiltrating endometriosis

Molecular Pain, 2017
Transient Receptor Potential Vanilloid 1 (TRPV1) and Transient Receptor Potential Ankyrin 1 (TRPA1) expressed mainly by primary sensory neurons function as major nociceptive integrators.
Noémi Bohonyi, Krisztina Pohóczky, Bálint Szalontai, Anikó Perkecz, Krisztina Kovács, Béla Kajtár, Lajos Orbán, Tamás Varga, Sarolta Szegedi, József Bódis, Zsuzsanna Helyes, Miklós Koppán   +11 more
doaj   +2 more sources

Transient Receptor Potential Channels in Vascular Mechanotransduction. [PDF]

Am J Hypertens
Abstract Transmural pressure and shear stress are mechanical forces that profoundly affect the smooth muscle cells (SMCs) comprising the vascular wall and the endothelial cells (ECs) lining the lumen. Pressure and flow are detected by mechanosensors in these cells and translated into appropriate responses to regulate blood pressure ...
Solano AS, Lavanderos B, Metwally E, Earley S.   +3 more
europepmc   +3 more sources

Changes in transient receptor potential vanilloid 1 and transient receptor potential vanilloid 4 in patients with lower urinary tract dysfunction [PDF]

Investigative and Clinical Urology, 2022
Purpose: We investigated the association between transient receptor potential vanilloid (TRPV) expression in human urothelium tissue and lower urinary tract dysfunction (LUTD).
Kang Jun Cho, Jun Sung Koh, Jin Bong Choi, Sang Hi Park , Weon Sun Lee, Joon Chul Kim   +5 more
doaj   +1 more source

TRPM4 and TRPV2 are two novel prognostic biomarkers and promising targeted therapy in UVM

Frontiers in Molecular Biosciences, 2022
Uveal melanoma (UVM) is the most common primary intraocular malignancy tumor in adults. Almost 50% of UVM patients develop metastatic disease, and is usually fatal within 1 year. However, the mechanism of etiology remains unclear. The lack of prognostic,
Jiong Wang, Sen Qiao, Shenzhi Liang, Cheng Qian, Yi Dong, Minghang Pei, Hongmei Wang, Guangming Wan   +7 more
doaj   +1 more source

Targeting ROS-sensitive TRP ion channels for relieving oxidative stress-related diseases based on nanomaterials

Materials Today Advances, 2023
Reactive oxygen species (ROS) play an important role in regulating various physiological functions by activating specific ion channels to mediate cell growth, proliferation, regeneration, and apoptosis.
Boying Li, Ning Li, Nana Wang, Chaoqun Li, Xiaoning Liu, Zhanshuo Cao, Chengfen Xing, Shu Wang   +7 more
doaj   +1 more source

Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology

Frontiers in Physiology, 2021
The transient receptor potential (TRP) channels have been described in almost every mammalian cell type. Several members of the Vanilloid (TRPV) subtype have been found to play important roles in modulating cardiac structure and function through Ca2 ...
Michael Miller, Sheryl E. Koch, Adam Veteto, Adam Veteto, Timothy Domeier, Jack Rubinstein, Jack Rubinstein   +6 more
doaj   +1 more source

Modulation of Calcium Transients in Cardiomyocytes by Transient Receptor Potential Canonical 6 Channels

Frontiers in Physiology, 2020
Transient receptor potential canonical 6 (TRPC6) channels are non-selective cation channels that are thought to underlie mechano-modulation of calcium signaling in cardiomyocytes.
Azmi A. Ahmad, Azmi A. Ahmad, Molly E. Streiff, Molly E. Streiff, Chris Hunter, Frank B. Sachse, Frank B. Sachse   +6 more
doaj   +1 more source