Results 31 to 40 of about 399,869 (302)
X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation
Molecular Pain, 2019 Radiotherapy-related pain is a common adverse reaction with a high incidence among cancer patients undergoing radiotherapy and remarkably reduces the quality of life. However, the mechanisms of ionizing radiation-induced pain are largely unknown. In this
Su Cun-Jin +9 more
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Transient Receptor Potential Channels in the Vasculature
Physiological Reviews, 2015 The mammalian genome encodes 28 distinct members of the transient receptor potential (TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for different ionic species. Multiple TRP channels are present in all cells and are involved in diverse aspects of cellular function, including sensory perception and signal transduction.
Scott, Earley, Joseph E, Brayden
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Frontiers in Molecular Neuroscience, 2022 Primary afferent neurons of the dorsal root ganglia (DRG) transduce peripheral nociceptive signals and transmit them to the spinal cord. These neurons also mediate analgesic control of the nociceptive inputs, particularly through the μ-opioid receptor ...
Wenting Ma +8 more
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Molecular Mechanisms of Dicentra Formosa’s Analgesic Effect
Medicine in Drug Discovery, 2020 Background: Surgeons, Native Americans, and Eclectics have all sworn to the multiple healing properties including anthelmintic, analgesic, and anti-cancer effects that Dicentra Formosa possesses.
Royale Gray-Lee, Jesun Lee
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The Role of Transient Receptor Potential Channel 6 Channels in the Pulmonary Vasculature
Frontiers in Immunology, 2017 Canonical or classical transient receptor potential channel 6 (TRPC6) is a Ca2+-permeable non-selective cation channel that is widely expressed in the heart, lung, and vascular tissues.
Monika Malczyk +8 more
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Haemorrhoids and transient receptor potential vanilloid 1 [PDF]
Gut, 2006 Haemorrhoids are extremely common, and approximately 10 million people are affected by haemorrhoidal disease in the USA.1 Many causes have been proposed to explain the pathogenesis of symptomatic haemorrhoids. The pathophysiological theory, made popular by Thomson’s studies, in which the elastic support of the anal cushions is thought to be broken, is ...
Di Mola F. F. +6 more
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Frontiers in Pharmacology, 2019 The sigma 1 receptor (σ1R) and the mu-opioid receptor (MOR) regulate the transient receptor potential (TRP) V1 calcium channel. A series of proteins are involved in the cross-regulation between MORs and calcium channels like the glutamate N-methyl-D ...
Elsa Cortés-Montero +4 more
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, 2020 Increased generation of reactive oxygen species (ROS) and altered Ca2+ handling cause vascular damage in hypertension. Mechanisms linking these systems are unclear, but TRPM2 (transient receptor potential melastatin 2) could be important because TRPM2 is
Karla B. Neves +6 more
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Redox Regulation of Transient Receptor Potential Channels [PDF]
Antioxidants & Redox Signaling, 2014 Significance: Environmental and endogenous reactive species such as reactive oxygen species (ROS), reactive nitrogen species (RNS), and other electrophiles are not only known to exert toxic effects on organisms, but are also emerging as molecules that mediate cell ...
Kozai, Daisuke +2 more
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Transient receptor potential channels in Alzheimer's disease
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007 Cognitive impairment and emotional disturbances in Alzheimer's disease (AD) result from the degeneration of synapses and neuronal death in the limbic system and associated regions of the cerebral cortex. An alteration in the proteolytic processing of the amyloid precursor protein (APP) results in increased production and accumulation of amyloid beta ...
Yamamoto, Shinichiro +4 more
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