Results 1 to 10 of about 6,514 (122)
Transient receptor potential channels in Flaviviridae infection: A comprehensive review [PDF]
ChannelsDiseases caused by Flaviviridae viruses exert profound global health and economic burdens due to their high incidence and associated mortality. Infection by the Flaviviridae family often leads to severe acute or chronic illnesses, including hemorrhagic ...
Fuchun Jiang +2 more
doaj +2 more sources
Role of transient receptor potential (TRP) channels in osteoarthritis: a comprehensive review [PDF]
Frontiers in PharmacologyOsteoarthritis (OA) is a chronic degenerative joint disease, primarily characterized by the degeneration of articular cartilage, synovial inflammation, and persistent pain, which severely impairs the quality of life for hundreds of millions of patients ...
Pengyan Qiao +9 more
doaj +2 more sources
Molecular details of ruthenium red pore block in TRPV channels
EMBO ReportsTransient receptor potential vanilloid (TRPV) channels play a critical role in calcium homeostasis, pain sensation, immunological response, and cancer progression. TRPV channels are blocked by ruthenium red (RR), a universal pore blocker for a wide array
Ruth A Pumroy +9 more
doaj +2 more sources
Frontiers in Medicine, 2021 The battle against the new coronavirus that continues to kill millions of people will be still long. Novel strategies are demanded to control infection, mitigate symptoms and treatment of COVID-19. This is even more imperative given the long sequels that
Filippo Liviero +3 more
doaj +1 more source
A functional nuclear localization sequence in the C. elegans TRPV channel OCR-2. [PDF]
PLoS ONE, 2011 The ability to modulate gene expression in response to sensory experience is critical to the normal development and function of the nervous system. Calcium is a key activator of the signal transduction cascades that mediate the process of translating a ...
Meredith J Ezak, Denise M Ferkey
doaj +1 more source
TRP channels: Role in neurodegenerative diseases and therapeutic targets
Heliyon, 2023 TRP (Transient receptor potential) channels are integral membrane proteins consisting of a superfamily of cation channels that allow permeability of both monovalent and divalent cations. TRP channels are subdivided into six subfamilies: TRPC, TRPV, TRPM,
Mashoque Ahmad Rather +6 more
doaj +1 more source
Evidence for Novel Pharmacological Sensitivities of Transient Receptor Potential (TRP) Channels in Schistosoma mansoni. [PDF]
PLoS Neglected Tropical Diseases, 2015 Schistosomiasis, caused by parasitic flatworms of the genus Schistosoma, is a neglected tropical disease affecting hundreds of millions globally. Praziquantel (PZQ), the only drug currently available for treatment and control, is largely ineffective ...
Swarna Bais +3 more
doaj +1 more source
TRP Channels in Cancer: Signaling Mechanisms and Translational Approaches
Biomolecules, 2023 Ion channels play a crucial role in a wide range of biological processes, including cell cycle regulation and cancer progression. In particular, the transient receptor potential (TRP) family of channels has emerged as a promising therapeutic target due ...
Matilde Marini +5 more
doaj +1 more source
Diagnostics, 2021 Spontaneous swallowing contributes to airway protection and depends on the activation of brainstem reflex circuits in the central pattern generator (CPG).
Weslania Nascimento +6 more
doaj +1 more source
Atypical pharmacology of schistosome TRPA1-like ion channels. [PDF]
PLoS Neglected Tropical Diseases, 2018 Parasitic flatworms of the genus Schistosoma cause schistosomiasis, a neglected tropical disease estimated to affect over 200 million people worldwide.
Swarna Bais +5 more
doaj +1 more source