Molecular details of ruthenium red pore block in TRPV channels
EMBO ReportsTransient receptor potential vanilloid (TRPV) channels play a critical role in calcium homeostasis, pain sensation, immunological response, and cancer progression. TRPV channels are blocked by ruthenium red (RR), a universal pore blocker for a wide array
Ruth A Pumroy +9 more
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A co-operative knock-on mechanism underpins Ca 2+ -selective cation permeation in TRPV channels [PDF]
Journal of General Physiology, 2022 The selective exchange of ions across cellular membranes is a vital biological process. Ca 2+ -mediated signalling is implicated in a broad array of physiological processes in cells, whilst elevated intracellular concentrations of Ca 2+ are cytotoxic.
Callum M. Ives +2 more
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A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]
PLoS ONE, 2013 TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Zhaohua Guo +4 more
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Differential Effects of TRPA and TRPV Channels on Behaviors of
Journal of Experimental Neuroscience, 2016 TRPA and TRPV ion channels are members of the transient receptor potential (TRP) cation channel superfamily, which mediates various sensory transductions.
Jennifer Thies +3 more
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A functional nuclear localization sequence in the C. elegans TRPV channel OCR-2. [PDF]
PLoS ONE, 2011 The ability to modulate gene expression in response to sensory experience is critical to the normal development and function of the nervous system. Calcium is a key activator of the signal transduction cascades that mediate the process of translating a ...
Meredith J Ezak, Denise M Ferkey
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Human mutations highlight an intersubunit cation–π bond that stabilizes the closed but not open or inactivated states of TRPV channels [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 SignificanceTransient receptor potential (TRP) channels are key cation channels that respond to thermal, chemical, electric, or mechanical stimuli. There are >60 mutations known in TrpV4 that cause defects in bone or neural development. Two mutations guided us to examine a cation–π bond, which we found to tie the four subunits together to help close
Jinfeng Teng +2 more
exaly +3 more sources
Evidence for Novel Pharmacological Sensitivities of Transient Receptor Potential (TRP) Channels in Schistosoma mansoni. [PDF]
PLoS Neglected Tropical Diseases, 2015 Schistosomiasis, caused by parasitic flatworms of the genus Schistosoma, is a neglected tropical disease affecting hundreds of millions globally. Praziquantel (PZQ), the only drug currently available for treatment and control, is largely ineffective ...
Swarna Bais +3 more
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Atypical pharmacology of schistosome TRPA1-like ion channels. [PDF]
PLoS Neglected Tropical Diseases, 2018 Parasitic flatworms of the genus Schistosoma cause schistosomiasis, a neglected tropical disease estimated to affect over 200 million people worldwide.
Swarna Bais +5 more
doaj +2 more sources
TRP Channels in Cancer: Signaling Mechanisms and Translational Approaches [PDF]
Biomolecules, 2023 Ion channels play a crucial role in a wide range of biological processes, including cell cycle regulation and cancer progression. In particular, the transient receptor potential (TRP) family of channels has emerged as a promising therapeutic target due ...
Matilde Marini +5 more
doaj +2 more sources
TRP Channels in Angiogenesis and Other Endothelial Functions [PDF]
Frontiers in Physiology, 2018 Angiogenesis is the growth of blood vessels mediated by proliferation, migration, and spatial organization of endothelial cells. This mechanism is regulated by a balance between stimulatory and inhibitory factors.
Tarik Smani +7 more
doaj +2 more sources