Results 1 to 10 of about 9,155 (170)

Structure of the full-length TRPV2 channel by cryo-EM [PDF]

Nature Communications, 2016
Transient receptor potential (TRP) proteins are Ca2+-permeable cation channels activated by a range of chemical and physical stimuli. Here the authors describe a cryo-EM structure of the full-length TRPV2 channel that provides insight into the regulation
Kevin W. Huynh, Matthew R. Cohen, Jiansen Jiang, Amrita Samanta, David T. Lodowski, Z. Hong Zhou, Vera Y. Moiseenkova-Bell   +6 more
doaj   +3 more sources

A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]

PLoS ONE, 2013
TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Zhaohua Guo, Christian Grimm, Lars Becker, Anthony J Ricci, Stefan Heller   +4 more
doaj   +6 more sources

TRPV4 is the temperature-sensitive ion channel of human sperm [PDF]

eLife, 2018
Ion channels control the ability of human sperm to fertilize the egg by triggering hyperactivated motility, which is regulated by membrane potential, intracellular pH, and cytosolic calcium.
Nadine Mundt, Marc Spehr, Polina V Lishko   +2 more
doaj   +5 more sources

Role of transient receptor potential (TRP) channels in osteoarthritis: a comprehensive review [PDF]

Frontiers in Pharmacology
Osteoarthritis (OA) is a chronic degenerative joint disease, primarily characterized by the degeneration of articular cartilage, synovial inflammation, and persistent pain, which severely impairs the quality of life for hundreds of millions of patients ...
Pengyan Qiao, Wei Wang, Sumiao Liu, Yanli Yang, Pingzhi Wang, Yang Liu, Yazhen Su, Peng Hu, Jie Pan, Liyun Zhang   +9 more
doaj   +2 more sources

A co-operative knock-on mechanism underpins Ca²⁺-selective cation permeation in TRPV channels

Journal of General Physiology, 2022
The selective exchange of ions across cellular membranes is a vital biological process. Ca2+-mediated signalling is implicated in a broad array of physiological processes in cells, whilst elevated intracellular concentrations of Ca2+ are cytotoxic. Due to the significance of this cation, strict Ca2+ concentration gradients are maintained across the ...
Callum M. Ives, Neil J. Thomson, Ulrich Zachariae   +2 more
openaire   +4 more sources

Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19

Frontiers in Medicine, 2021
The battle against the new coronavirus that continues to kill millions of people will be still long. Novel strategies are demanded to control infection, mitigate symptoms and treatment of COVID-19. This is even more imperative given the long sequels that
Filippo Liviero, Manuela Campisi, Paola Mason, Sofia Pavanello   +3 more
doaj   +1 more source

A REVIEW ON ROLE OF TRPV CATION CHANNELS

Journal of Biomedical and Pharmaceutical Research, 2021
The mammalian branch of the Transient Receptor Potential (TRP) superfamily of cation channels consists of 28 members. They can be subdivided in six main subfamilies: the TRPC (‘Canonical’), TRPV (‘Vanilloid’), TRPM (‘Melastatin’), TRPP (‘Polycystin’), TRPML (‘Mucolipin’) and the TRPA (‘Ankyrin’) group.
Deep Sharma, Rekha Rana, Kiran Thakur
openaire   +2 more sources

A functional nuclear localization sequence in the C. elegans TRPV channel OCR-2. [PDF]

PLoS ONE, 2011
The ability to modulate gene expression in response to sensory experience is critical to the normal development and function of the nervous system. Calcium is a key activator of the signal transduction cascades that mediate the process of translating a ...
Meredith J Ezak, Denise M Ferkey
doaj   +1 more source

TRP channels: Role in neurodegenerative diseases and therapeutic targets

Heliyon, 2023
TRP (Transient receptor potential) channels are integral membrane proteins consisting of a superfamily of cation channels that allow permeability of both monovalent and divalent cations. TRP channels are subdivided into six subfamilies: TRPC, TRPV, TRPM,
Mashoque Ahmad Rather, Andleeb Khan, Lianchun Wang, Sadaf Jahan, Muneeb U. Rehman, Hafiz A. Makeen, Syam Mohan   +6 more
doaj   +1 more source

Human mutations highlight an intersubunit cation–π bond that stabilizes the closed but not open or inactivated states of TRPV channels [PDF]

Proceedings of the National Academy of Sciences, 2019
SignificanceTransient receptor potential (TRP) channels are key cation channels that respond to thermal, chemical, electric, or mechanical stimuli. There are >60 mutations known in TrpV4 that cause defects in bone or neural development. Two mutations guided us to examine a cation–π bond, which we found to tie the four subunits together to help close
Jinfeng Teng, Andriy Anishkin, Ching Kung, Paul Blount   +3 more
openaire   +2 more sources