Results 21 to 30 of about 1,008,370 (159)
A functional nuclear localization sequence in the C. elegans TRPV channel OCR-2. [PDF]
PLoS ONE, 2011 The ability to modulate gene expression in response to sensory experience is critical to the normal development and function of the nervous system. Calcium is a key activator of the signal transduction cascades that mediate the process of translating a ...
Meredith J Ezak, Denise M Ferkey
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TRP channels: Role in neurodegenerative diseases and therapeutic targets
Heliyon, 2023 TRP (Transient receptor potential) channels are integral membrane proteins consisting of a superfamily of cation channels that allow permeability of both monovalent and divalent cations. TRP channels are subdivided into six subfamilies: TRPC, TRPV, TRPM,
Mashoque Ahmad Rather +6 more
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Evidence for Novel Pharmacological Sensitivities of Transient Receptor Potential (TRP) Channels in Schistosoma mansoni. [PDF]
PLoS Neglected Tropical Diseases, 2015 Schistosomiasis, caused by parasitic flatworms of the genus Schistosoma, is a neglected tropical disease affecting hundreds of millions globally. Praziquantel (PZQ), the only drug currently available for treatment and control, is largely ineffective ...
Swarna Bais +3 more
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TRP Channels in Cancer: Signaling Mechanisms and Translational Approaches
Biomolecules, 2023 Ion channels play a crucial role in a wide range of biological processes, including cell cycle regulation and cancer progression. In particular, the transient receptor potential (TRP) family of channels has emerged as a promising therapeutic target due ...
Matilde Marini +5 more
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Diagnostics, 2021 Spontaneous swallowing contributes to airway protection and depends on the activation of brainstem reflex circuits in the central pattern generator (CPG).
Weslania Nascimento +6 more
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Atypical pharmacology of schistosome TRPA1-like ion channels. [PDF]
PLoS Neglected Tropical Diseases, 2018 Parasitic flatworms of the genus Schistosoma cause schistosomiasis, a neglected tropical disease estimated to affect over 200 million people worldwide.
Swarna Bais +5 more
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Transient Receptor Potential Vanilloid (TRPV) channels: Basal Properties and physiological potential [PDF]
, 2022 Transient receptor potential vanilloid (TRPV) channels are TRP homologs and have been classified into six subfamilies. They are unique mediators of sensory signals with multiple physiological effects and are potential targets for developing new therapies
Sasase, Tomohiko +2 more
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Vascular Dysfunction in Diabetes and Obesity: Focus on TRP Channels
Frontiers in Physiology, 2021 Transient receptor potential (TRP) superfamily consists of a diverse group of non-selective cation channels that has a wide tissue distribution and is involved in many physiological processes including sensory perception, secretion of hormones ...
Raiana dos Anjos Moraes +4 more
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Structural Insight into the Assembly of TRPV Channels [PDF]
, 2014 SummaryTransient receptor potential (TRP) proteins are a large family of polymodal nonselective cation channels. The TRP vanilloid (TRPV) subfamily consists of six homologous members with diverse functions.
Stewart, Phoebe L. +10 more
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Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel
Nature Communications, 2016 TRPV are cation channels activated by physical and chemical stimuli. Here the authors show that nicotinamide is a soluble, endogenous agonist for orthologous TRPV channels fromC.
Awani Upadhyay +10 more
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