Results 1 to 10 of about 64,951 (237)

Beneficial Effects of Capsaicin in Disorders of the Central Nervous System

Molecules, 2022
Capsaicin is a natural compound found in chili peppers and is used in the diet of many countries. The important mechanism of action of capsaicin is its influence on TRPV1 channels in nociceptive sensory neurons.
Michał Pasierski, Bartłomiej Szulczyk
exaly   +3 more sources

Gut microbiota-dependent 24-hydroxycholesterol metabolism contributes to capsaicin-induced amelioration of Alzheimer’s disease-like pathology in mice [PDF]

Nature Communications
Dietary capsaicin intake appears to affect the pathogenesis of Alzheimer’s disease (AD), while the underlying mechanisms remain unclear. Here, we found in human cohorts that moderate-to-high level of dietary capsaicin intake was associated with improved ...
Yawen Li, Hui Wang, Dongyuan Zhang, Shiqi Wang, Zheng Li, Jingjie Li, Shentao Tai, Dandan Tong, Bifeng Wang, Dingbing Lu, Shulu Yuan, Weiqi Sun, Biyu Yang, Chaobo Bai, Qi Wang, Jiuyang Ding, Zhihao Wang, Yang Gao, Haitao Yu, Kun Cui, Chang Liu, Jian Mao, Yun Yao, Fengyu Liu, You Wan, Junliang Yuan, Xuemei Liu, Jie Zheng   +27 more
doaj   +2 more sources

Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases

Molecules, 2016
Capsaicin is the most predominant and naturally occurring alkamide found in Capsicum fruits. Since its discovery in the 19th century, the therapeutic roles of capsaicin have been well characterized. The potential applications of capsaicin range from food
Shaherin Basith, Minghua Cui, Sun Choi
exaly   +3 more sources

Hydroalcoholic extracts of three Artemisia species attenuate dental pulp pain and pain-related abnormal feeding behavior of rats [PDF]

The Iranian Journal of Veterinary Science and Technology, 2022
This study considered the therapeutic efficacy of three different Artemisia species extracts on capsaicin-induced dental pulp pain and pain-associated changes in feeding behaviors in adult male Wistar rats.
Jahangir Haghani, Fatemeh Haghani, Amirhosein Soleimani, Mehdi Abbasnejad, Mojteba Khodami, Razieh Kooshki, Maryam Raoof   +6 more
doaj   +1 more source

The Natural Chemotherapeutic Capsaicin Activates AMPK through LKB1 Kinase and TRPV1 Receptors in Prostate Cancer Cells

Pharmaceutics, 2022
The natural bioactive compound capsaicin has been reported to have anticancer activity, although the underlying mechanism of action has not been completely clarified.
Belén G. Sánchez, Alicia Bort, José M. Mora-Rodríguez, Inés Díaz-Laviada   +3 more
doaj   +1 more source

Immunomodulatory and anti-oxidative effect of the direct TRPV1 receptor agonist capsaicin on Schwann cells

Journal of Neuroinflammation, 2020
Background Only few studies describe the impact of nutritive factors on chronic inflammatory demyelinating polyneuropathy (CIDP), an inflammatory disease of the peripheral nervous system.
Thomas Grüter, Alina Blusch, Jeremias Motte, Melissa Sgodzai, Hussein Bachir, Rafael Klimas, Björn Ambrosius, Ralf Gold, Gisa Ellrichmann, Kalliopi Pitarokoili   +9 more
doaj   +1 more source

Nitro Capsaicin Suppressed Microglial Activation and TNF-α-Induced Brain Microvascular Endothelial Cell Damage

Biomedicines, 2022
Chronically activated microglia and brain vascular damage are major causes of neuroinflammation. The aim of this study was to determine the anti-inflammatory effects of nitro capsaicin, a newly modified capsaicin with less irritating characteristics ...
Sopana Jamornwan, Tanida Chokpanuwat, Kwanchanok Uppakara, Thanet Laorob, Uthai Wichai, Pimonrat Ketsawatsomkron, Witchuda Saengsawang   +6 more
doaj   +1 more source

Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway. [PDF]

PLoS ONE, 2010
Small cell lung cancer (SCLC) is characterized by rapid progression and low survival rates. Therefore, novel therapeutic agents are urgently needed for this disease. Capsaicin, the active ingredient of chilli peppers, displays anti-proliferative activity
Kathleen C Brown, Ted R Witte, W Elaine Hardman, Haitao Luo, Yi C Chen, A Betts Carpenter, Jamie K Lau, Piyali Dasgupta   +7 more
doaj   +1 more source

Capsaicin, a Phytochemical From Chili Pepper, Alleviates the Ultraviolet Irradiation-Induced Decline of Collagen in Dermal Fibroblast via Blocking the Generation of Reactive Oxygen Species

Frontiers in Pharmacology, 2022
Capsaicin, a major ingredient in chili pepper, has broad pharmaceutical applications, including relieving pain, anti-inflammation, and treating psoriasis.
Qiyun Wu, Qiyun Wu, Panzhu Bai, Hongsheng Guo, Maggie S. S. Guo, Yingjie Xia, Yiteng Xia, Xiong Gao, Xiaoyang Wang, Jiahui Wu, Jiahui Wu, Tina T. X. Dong, Tina T. X. Dong, Karl W. K. Tsim, Karl W. K. Tsim   +14 more
doaj   +1 more source

The Effect of Capsaicin on Salivary Gland Dysfunction

Molecules, 2016
Capsaicin (trans-8-methyl-N-vanilyl-6-nonenamide) is a unique alkaloid isolated from hot chili peppers of the capsicum family. Capsaicin is an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), which is expressed in nociceptive sensory ...
Yong-Hwan Shin, Jin Man Kim, Kyungpyo Park   +2 more
doaj   +1 more source