TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors
Cell Reports, 2022 The molecular mechanism underlying the functional interaction between H1R and TRPV1 remains unclear. We show here that H1R directly binds to the carboxy-terminal region of TRPV1 at residues 715-725 and 736-749. Cell-penetrating peptides containing these sequences suppress histamine-induced scratching behavior in a cheek injection model.
Yong Li, Aiwu Zhou, Jinke Cheng
exaly +4 more sources
Upregulated Expression of TRPV1 and TRPV4 in the Urethra Following Cyclophosphamide-Induced Cystitis in Rats: A Potential Mechanism of Bladder-Urethral Dysfunction [PDF]
International Neurourology JournalPurpose This study aimed to investigate the impact of cyclophosphamide (CYP)-induced cystitis on the expression of transient receptor potential vanilloid 1 (TRPV1) and 4 (TRPV4) in the rat urethra, and to evaluate their potential roles in urethral ...
Yeonwoo Jeong +4 more
doaj +2 more sources
Near Infrared Responsive Gold Nanorods Attenuate Osteoarthritis Progression by Targeting TRPV1
Advanced ScienceOsteoarthritis (OA) is the most common degenerative joint disease worldwide, with the main pathological manifestation of articular cartilage degeneration. It have been investigated that pharmacological activation of transient receptor potential vanilloid
Dongquan Shi
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Transient receptor potential vanilloid type-1 regulates periodontal disease damage via the PI3K/AKT signaling pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): This study aimed to investigate the function of transient receptor potential vanilloid 1 (TRPV1) in regulating periodontal lesions. In addition, we explored the underlying mechanism of the phosphatidylinositol 3-kinase/protein kinase B ...
xiaolu xu +3 more
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Acta Medica Alanya, 2023 Aim: We aimed to reveal the role of doxorubicin (Dox), melatonin (Mel) and transient receptor potential Vanilloid 1 (TRPV1) channels in bone and cartilage cancer cells during the treatment process.
Anıl Gülcü +2 more
doaj +1 more source
Thermo-sensitive TRP channels and prevention of major chronic diseases
Di-san junyi daxue xuebao, 2022 American scientists David Julius and Ardem Patapoutian won the Nobel Prize in physiology or medicine in 2021 for their groundbreaking discoveries of capsaicin receptor TRPV1 and menthol receptor TRPM8, revealing the secrets of temperature perception. The
ZHU Zhiming, LIU Daoyan
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Electroacupuncture reduces chronic fibromyalgia pain through attenuation of transient receptor potential vanilloid 1 signaling pathway in mouse brains [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Fibromyalgia pain is a mysterious clinical pain syndrome, characterized by inflammation in the brain, whose molecular mechanisms are still unknown.
Chia-Ming Yen +2 more
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Journal of the International Society of Sports Nutrition, 2022 Background Prior evidence suggests that capsinoids ingestion may increase resting energy expenditure (EE) and fat oxidation (FATox), yet whether they can modulate those parameters during exercise conditions remains poorly understood. We hypothesized that
Francisco J. Osuna-Prieto +11 more
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TRPV1 activation induces cell death of TM3 mouse Leydig cells
Journal of Animal Reproduction and Biotechnology, 2021 The role of transient receptor potential vanilloid receptor-1 (TRPV1) has been primarily investigated in pain sensory neurons. Relatively, little research has been performed in testicular cells.
Eun-Jin Kim +6 more
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Expression of TRPV1 as A Heat Sensitive Voltage-Dependent Ion Channel and Oxidative Stress in Sperm Samples of Infertile Men with Varicocele: A Case-Control Study [PDF]
Cell Journal, 2022 Objective: Transient receptor potential vanilloid 1 (TRPV1) is a heat-activated nonselective cation channel that playsimportant role in the spermatogenesis, capacitation, acrosome reaction and sperm/oocyte fusion.
Sahar Salahshouri +4 more
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