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The TRPV1 receptor and nociception
Seminars in Cell and Developmental Biology, 2006The capsaicin receptor TRPV1 is an emerging target for the treatment of pain with a unique expression profile in peripheral nociceptors and the ability to show polymodal activation, TRPV1 is an important integrator of responses to inflammatory mediators. Sensitization of TRPV1 during chronic pain is believed to contribute to the transduction of noxious
Narender R Gavva
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TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors
Cell Reports, 2022 The molecular mechanism underlying the functional interaction between H1R and TRPV1 remains unclear. We show here that H1R directly binds to the carboxy-terminal region of TRPV1 at residues 715-725 and 736-749. Cell-penetrating peptides containing these sequences suppress histamine-induced scratching behavior in a cheek injection model.
Yong Li, Aiwu Zhou, Jinke Cheng
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Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity
Cell, 2019Tara N Edwards, Jonhan Ho, Brian Davis
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TRPV1 Gene Knockout Impairs Postischemic Recovery in Isolated Perfused Heart in Mice
Circulation, 2005Donna H Wang
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Optical Control of TRPV1 Channels
Angewandte Chemie - International Edition, 2013Dirk Trauner, Marco Stein
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TRPV1: Structure, Endogenous Agonists, and Mechanisms
International Journal of Molecular Sciences, 2020Tamara Rosenbaum
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Targeting TRPV1 for pain relief: limits, losers and laurels
Expert Opinion on Investigational Drugs, 2012Arpad Szallasi
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The functions of TRPA1 and TRPV1: moving away from sensory nerves
British Journal of Pharmacology, 2012Elizabeth S Fernandes
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