Upregulated Expression of TRPV1 and TRPV4 in the Urethra Following Cyclophosphamide-Induced Cystitis in Rats: A Potential Mechanism of Bladder-Urethral Dysfunction [PDF]
International Neurourology JournalPurpose This study aimed to investigate the impact of cyclophosphamide (CYP)-induced cystitis on the expression of transient receptor potential vanilloid 1 (TRPV1) and 4 (TRPV4) in the rat urethra, and to evaluate their potential roles in urethral ...
Yeonwoo Jeong +4 more
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Transient receptor potential vanilloid type-1 regulates periodontal disease damage via the PI3K/AKT signaling pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): This study aimed to investigate the function of transient receptor potential vanilloid 1 (TRPV1) in regulating periodontal lesions. In addition, we explored the underlying mechanism of the phosphatidylinositol 3-kinase/protein kinase B ...
xiaolu xu +3 more
doaj +1 more source
Acta Medica Alanya, 2023 Aim: We aimed to reveal the role of doxorubicin (Dox), melatonin (Mel) and transient receptor potential Vanilloid 1 (TRPV1) channels in bone and cartilage cancer cells during the treatment process.
Anıl Gülcü +2 more
doaj +1 more source
Thermo-sensitive TRP channels and prevention of major chronic diseases
Di-san junyi daxue xuebao, 2022 American scientists David Julius and Ardem Patapoutian won the Nobel Prize in physiology or medicine in 2021 for their groundbreaking discoveries of capsaicin receptor TRPV1 and menthol receptor TRPM8, revealing the secrets of temperature perception. The
ZHU Zhiming, LIU Daoyan
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Electroacupuncture reduces chronic fibromyalgia pain through attenuation of transient receptor potential vanilloid 1 signaling pathway in mouse brains [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Fibromyalgia pain is a mysterious clinical pain syndrome, characterized by inflammation in the brain, whose molecular mechanisms are still unknown.
Chia-Ming Yen +2 more
doaj +1 more source
Journal of the International Society of Sports Nutrition, 2022 Background Prior evidence suggests that capsinoids ingestion may increase resting energy expenditure (EE) and fat oxidation (FATox), yet whether they can modulate those parameters during exercise conditions remains poorly understood. We hypothesized that
Francisco J. Osuna-Prieto +11 more
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TRPV1 activation induces cell death of TM3 mouse Leydig cells
Journal of Animal Reproduction and Biotechnology, 2021 The role of transient receptor potential vanilloid receptor-1 (TRPV1) has been primarily investigated in pain sensory neurons. Relatively, little research has been performed in testicular cells.
Eun-Jin Kim +6 more
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The science of “smell” and the noble for “hugs:” making “sense?”
Asian Journal of Medical Sciences, 2021 David Julius and Ardem Patapoutian were jointly awarded the 2021 Nobel Prize in Physiology and Medicine for their discoveries of receptors for temperature and touch.
Ruby Dhar +2 more
doaj +1 more source
Expression of TRPV1 as A Heat Sensitive Voltage-Dependent Ion Channel and Oxidative Stress in Sperm Samples of Infertile Men with Varicocele: A Case-Control Study [PDF]
Cell Journal, 2022 Objective: Transient receptor potential vanilloid 1 (TRPV1) is a heat-activated nonselective cation channel that playsimportant role in the spermatogenesis, capacitation, acrosome reaction and sperm/oocyte fusion.
Sahar Salahshouri +4 more
doaj +1 more source
Clinical and Experimental Hypertension, 2021 Background: High-salt intake after renal ischemia/reperfusion (I/R) injury leads to hypertension and further renal injury, but the mechanisms are largely unknown.
Shuang-Quan Yu +2 more
doaj +1 more source