Results 11 to 20 of about 37,042 (291)

Monoacylglycerols Activate TRPV1-A Link between Phospholipase C and TRPV1 [PDF]

PLoS ONE, 2013
Phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate generates diacylglycerol, inositol 1,4,5-trisphosphate and protons, all of which can regulate TRPV1 activity via different mechanisms.
Andersson, David A, Peter M. Zygmunt (241661), Bryndis Birnir (113570), Alain Eschalier (209750), Stuart Bevan (303154), Pouya Movahed, Edward D. Högestätt (241662), Charlotte Simonsen (441655), Zygmunt, Peter M, Andersson, David A., Bevan, Stuart, Andersson, David, Jonsson, Bo A. G., Anna Ermund (241659), Jönsson, Bo, a G, Blomgren, Anders, Eschalier, Alain, Zygmunt, Peter M., Movahed, Pouya, Simonsen, Charlotte, Mallet, Christophe, Högestätt, Edward, D, Ana Gomis (491626), Bo A G Jönsson, Anders Blomgren, Gomis, Ana, Jönsson, Bo A G, Birnir, Bryndis, Christophe Mallet, Edward D Högestätt, Anna Ermund, Pouya Movahed (491625), David A. Andersson (303152), Jönsson, Bo A, Peter M Zygmunt, Anders Blomgren (441654), Högestätt, Edward D, Zygmunt, Peter, Bo A. G. Jönsson (241660), Charlotte Simonsen, Alain Eschalier, David A Andersson, Stuart Bevan, Bevan, Stuart; id_orcid, Andersson, David, A, Ermund, Anna, Bryndis Birnir, Birnir, Bryndis,, Christophe Mallet (241657), Andersson, David A; id_orcid, Ana Gomis, Zygmunt, Peter, M, Hogestatt, Edward D., Högestätt, Edward, Movahed Rad, Pouya   +54 more
core   +11 more sources

Calpain cleaves the distal carboxyl terminus of TRPV1 and modulates its tachyphylaxis [PDF]

Cell & Bioscience
Background Transient receptor potential vanilloid-1 (TRPV1) plays a critical role in noxious heat sensation in physiological conditions and pain hypersensitivity in pathological pain.
Jin-Yan Jiang, Xiao-Chen Wang, Jing Yang, Shu-Wen Gao, Ji-Xuan Xu, Mu-Lan Chen, Zhong-Zhe Zhang, Jiao Liu, Yun Wang, Ping Liang, Ying Zhang   +10 more
doaj   +2 more sources

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain. [PDF]

Adv Sci (Weinh)
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Pan Y, Li P, Chen Y, Dong Z, Li Y, Liu B, Tai Y, Wang C, Fang J, Yin C, Liu B.   +10 more
europepmc   +2 more sources

Near Infrared Responsive Gold Nanorods Attenuate Osteoarthritis Progression by Targeting TRPV1

Advanced Science
Osteoarthritis (OA) is the most common degenerative joint disease worldwide, with the main pathological manifestation of articular cartilage degeneration. It have been investigated that pharmacological activation of transient receptor potential vanilloid
Dongquan Shi
exaly   +2 more sources

Lipoxygenase-derived eicosanoids in myocardial ischaemia-reperfusion injury: the role of sensory C-fibres and TRPV1 [PDF]

, 2010
PhDIt is well established that the 12-lipoxygenase (12-LOX) pathway of arachidonic acid (AA) metabolism is stimulated within the myocardium by episodes of ischaemia, and there is considerable evidence showing that eicosanoids derived via this pathway ...
Goddard, Alison
core   +4 more sources

Transient receptor potential vanilloid type-1 regulates periodontal disease damage via the PI3K/AKT signaling pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): This study aimed to investigate the function of transient receptor potential vanilloid 1 (TRPV1) in regulating periodontal lesions. In addition, we explored the underlying mechanism of the phosphatidylinositol 3-kinase/protein kinase B ...
xiaolu xu, Yue-heng Li, Zhengyan Yang, Zhi Zhou   +3 more
doaj   +1 more source

Sertraline Alleviates Chronic Prostatitis by Regulating the TRPV1 Channel [PDF]

Journal of Inflammation Research
Yongfeng Lao,1,2 Yanan Bai,1,2 Xin Guan,1,2 Jian Wang,1,2 Yanan Wang,1,2 Rongxin Li,1,2 Yongqiang Ding,1,2 Zhilong Dong1,2 1Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, People’s Republic of China; 2Department of Urology, The ...
Lao Y, Bai Y, Guan X, Wang J, Wang Y, Li R, Ding Y, Dong Z   +7 more
doaj   +1 more source

Apoptosis Induction Through Increased TRPV1 Activation by Synergic Effect of Melatonin and Doxorubicin in Human Osteosarcoma and Chondrosarcoma Cell Lines

Acta Medica Alanya, 2023
Aim: We aimed to reveal the role of doxorubicin (Dox), melatonin (Mel) and transient receptor potential Vanilloid 1 (TRPV1) channels in bone and cartilage cancer cells during the treatment process.
Anıl Gülcü, İshak Suat Övey, Ahmet Koçak   +2 more
doaj   +1 more source

Thermo-sensitive TRP channels and prevention of major chronic diseases

Di-san junyi daxue xuebao, 2022
American scientists David Julius and Ardem Patapoutian won the Nobel Prize in physiology or medicine in 2021 for their groundbreaking discoveries of capsaicin receptor TRPV1 and menthol receptor TRPM8, revealing the secrets of temperature perception. The
ZHU Zhiming, LIU Daoyan
doaj   +1 more source

Electroacupuncture reduces chronic fibromyalgia pain through attenuation of transient receptor potential vanilloid 1 signaling pathway in mouse brains [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Fibromyalgia pain is a mysterious clinical pain syndrome, characterized by inflammation in the brain, whose molecular mechanisms are still unknown.
Chia-Ming Yen, Ching-Liang Hsieh, Yi-Wen Lin   +2 more
doaj   +1 more source