Results 1 to 10 of about 12,428 (199)
The role of TRPA1 channels in thermosensation
Cell Insight, 2022 Transient receptor potential ankyrin 1 (TRPA1) is a polymodal nonselective cation channel sensitive to different physical and chemical stimuli. TRPA1 is associated with many important physiological functions in different species and thus is involved in ...
Keyi Zhang
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No functional TRPA1 in cardiomyocytes [PDF]
Acta Physiologica, 2021 AbstractAimThere is mounting evidence that TRPA1 has a role in cardiac physiology and pathophysiology. We aim to clarify the site of TRPA1 expression in the heart and in particular whether the channel is expressed in cardiomyocytes.MethodsDue to the high calcium conductance of TRPA1, and marginal calcium changes being detectable, microfluorimetry in ...
Lukas F Reissig +2 more
exaly +3 more sources
TRPA1 channels in the vasculature [PDF]
British Journal of Pharmacology, 2012 This review is focused on the role of the ankyrin (A) transient receptor potential (TRP) channel TRPA1 in vascular regulation. TRPA1 is activated by environmental irritants, pungent compounds found in foods such as garlic, mustard and cinnamon, as well as metabolites produced during oxidative stress. The structure of the channel is distinguished by the
Scott Earley
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Journal of Neurophysiology, 2019 The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed in pain-sensing neurons and other tissues and has become a major target in the development of novel pharmaceuticals. A remarkable feature of the channel is its long list of activators, many of which we are exposed to in daily life.
Jannis Meents +2 more
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Dexmedetomidine protects against ischemia and reperfusion-induced kidney injury in rats by inhibiting the expression of TRPM2 and TRPA1 channels [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Renal ischemia and reperfusion (I/R) injury is a potentially serious issue encountered during various medical and surgical procedures. This condition is clinically significant because of its high incidence and mortality rate. In this study,
Abdulkadir Uzunboy +5 more
doaj +2 more sources
Cells, 2014 Transient receptor potential (TRP) ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are implicated in modulation of cough and nociception. In vivo, TRPA1 and TRPV1 are often co-expressed in neurons and TRPA1V1 hetero-tetramer formation is noted in ...
Laura Sadofsky +2 more
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TRPA1‐mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1 [PDF]
European Journal of Neuroscience, 2009 AbstractThe transient receptor potential (TRP)A1 channel is involved in the transduction of inflammation‐induced noxious stimuli from the periphery. Previous studies have characterized the properties of TRPA1 in heterologous expression systems. However, there is little information on the properties of TRPA1‐mediated currents in sensory neurons.
Armen Akopian +2 more
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TRPA1 Expressed by Hepatocytes and Liver Macrophages Does Not Mediate Inflammatory Infiltration and Steatosis in a Mouse Model of Chronic Alcohol-Induced Liver Injury [PDF]
CellsTransient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel, and its activator, the alcohol breakdown product acetaldehyde, plays a key role in the pathomechanism of alcoholic liver disease (ALD).
Dorottya Luca Fehér +7 more
doaj +2 more sources
TRPA1 expression and its functional activation in rodent cortex [PDF]
Open Biology, 2017 TRPA1 is a non-selective cation channel involved in pain sensation and neurogenic inflammation. Although TRPA1 is well established in a number of organs including the nervous system, its presence and function in the mammalian cortex remains unclear. Here,
Ehsan Arabzadeh +2 more
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Journal of Physiological SciencesTRPA1 was first identified as a noxious cold receptor in mice in 2003. Multiple TRPA1 genes have since been isolated, indicating that TRPA1 emerged early in evolution and showing the existence of TRPA1 variants in a range of species, including insects.
Makoto Tominaga
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