Results 1 to 10 of about 15,549 (234)

TRPA1 Contributes to Cold Hypersensitivity [PDF]

The Journal of Neuroscience, 2010
TRPA1 is a nonselective cation channel expressed by nociceptors. Although it is widely accepted that TRPA1 serves as a broad irritancy receptor for a variety of reactive chemicals, its role in cold sensation remains controversial.
Ardem Patapoutian, Christopher M. Fanger, Nate Deering, Magdalene M. Moran, Sarah Murphy, Melissa Heiry, Michael Zhao, Jayhong A. Chong, Colby A. Cook, Clifford J. Woolf, Neil J. Hayward, Michael Costigan, Lee B. Barrett, Marc D'Amours, Donato del Camino, Gary J. Brenner, Matt J. Petrus, Taryn J. Earley   +17 more
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Efeito terapêutico do galato de etila na nocicepção neuropática e induzida por algógenos em camundongos [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2014.O galato de etila (GE) é um composto fenólico encontrado em um grande número de espécies de ...
Coelho, Igor dos Santos
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Annexin A2 regulates TRPA1-dependent nociception.

, 2014
The transient receptor potential A1 (TRPA1) channel is essential for vertebrate pain. Even though TRPA1 activation by ligands has been studied extensively, the molecular machinery regulating TRPA1 is only poorly understood.
Sereda, M, Narayanan, P., Cervellini, I., Gomez-Varela, D., Avenali, L, Rouwette, T, Avenali, L., Sereda, M., Cervellini, I, Gomez-Varela, D, Narayanan, P, Cervellini, Ilaria, Schmidt, M., Rouwette, T., Schmidt, M   +14 more
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Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction

Journal of Inflammation, 2018
Background Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger.
Songjiang Yin, Li Zhang, Liang Ding, Zhengquan Huang, Bo Xu, XiaoChen Li, Peimin Wang, Jun Mao   +7 more
doaj   +1 more source

High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]

, 2007
Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B, Robinson, M, Rugiero, F, Colless, B, Drew, LJ, Brust, A, Heinzmann, S, Lewis, RJ, Wood, JN, Gale, JE, Cesare, P, Bowden, S   +11 more
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Neurophysiological and histopathological evaluation of small fiber pathways as diagnostic characterization of neuropathic pain and autonom dysfunction syndromes

, 2012
This manuscript is made up of two individual not related articles about peripheral neuropathic pain syndrome. The first article reports the effect on pain relief in patients with peripheral neuropathic pain after brachial plexus lesions or distal ...
Devigli, Grazia, Devigili, Grazia
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Warmth suppresses and desensitizes damage-sensing ion channel TRPA1

Molecular Pain, 2012
Background Acute or chronic tissue damage induces an inflammatory response accompanied by pain and alterations in local tissue temperature. Recent studies revealed that the transient receptor potential A1 (TRPA1) channel is activated by a wide variety of
Wang Sen, Lee Jongseok, Ro Jin Y, Chung Man-Kyo   +3 more
doaj   +1 more source

Activation of TRPA1 by membrane permeable local anesthetics

Molecular Pain, 2011
Background Low concentrations of local anesthetics (LAs) suppress cellular excitability by inhibiting voltage-gated Na+ channels. In contrast, LAs at high concentrations can be excitatory and neurotoxic. We recently demonstrated that LA-evoked activation
Kronewald Sergej, Lattrell Anja, Leffler Andreas, Niedermirtl Florian, Nau Carla   +4 more
doaj   +1 more source

TRPA1 Ion Channel Mediates the Analgesic Effects of Acupuncture at the ST36 Acupoint in Mice Suffering from Arthritis

Journal of Inflammation Research
Kaifang Yao,1,* Zhihan Chen,1,* Yanwei Li,1 Baomin Dou,1 Zhifang Xu,1– 3 Yajing Ma,1 Simin Du,1 Jiangshan Wang,1 Jiangjiang Fu,1 Qi Liu,1 Zezhi Fan,1 Yangyang Liu,1– 3 Xiaowei Lin,1– 3 Yuan Xu,1– 3 Yuxin Fang,1– 3 Shenjun Wang,1– 3 Yi Guo1,3,4 ...
Yao K, Chen Z, Li Y, Dou B, Xu Z, Ma Y, Du S, Wang J, Fu J, Liu Q, Fan Z, Liu Y, Lin X, Xu Y, Fang Y, Wang S, Guo Y   +16 more
doaj  

Expression of TRPA1 in pancreatic beta cells.

, 2012
a. RT-PCR shows the expression of TRPA1 mRNA in DRG neurons, whole pancreas (Pan), isolated islets (Isl), a pancreatic beta cell line (RIN), but not in a pancreatic alpha cell line (INR). b. Western blots show the expression of TRPA1 protein in RIN cells
Linlin Zhong (160871), Tsung-han Hsieh (160878), Louis S. Premkumar (160904), Mruvil Abooj (160885), Lauren Hughes (160897), Mahendra Bishnoi (160891), De-Shou Cao (160865)   +6 more
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