Results 1 to 10 of about 12,878 (216)
The role of TRPA1 channels in thermosensation
Cell Insight, 2022 Transient receptor potential ankyrin 1 (TRPA1) is a polymodal nonselective cation channel sensitive to different physical and chemical stimuli. TRPA1 is associated with many important physiological functions in different species and thus is involved in ...
Lai Ren
exaly +5 more sources
No functional TRPA1 in cardiomyocytes [PDF]
Acta Physiologica, 2021 AbstractAimThere is mounting evidence that TRPA1 has a role in cardiac physiology and pathophysiology. We aim to clarify the site of TRPA1 expression in the heart and in particular whether the channel is expressed in cardiomyocytes.MethodsDue to the high calcium conductance of TRPA1, and marginal calcium changes being detectable, microfluorimetry in ...
Lukas F Reissig +2 more
exaly +3 more sources
Journal of Neurophysiology, 2019 The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed in pain-sensing neurons and other tissues and has become a major target in the development of novel pharmaceuticals. A remarkable feature of the channel is its long list of activators, many of which we are exposed to in daily life.
Jannis Meents +2 more
exaly +3 more sources
TRPA1 channels in the vasculature [PDF]
British Journal of Pharmacology, 2012 This review is focused on the role of the ankyrin (A) transient receptor potential (TRP) channel TRPA1 in vascular regulation. TRPA1 is activated by environmental irritants, pungent compounds found in foods such as garlic, mustard and cinnamon, as well as metabolites produced during oxidative stress. The structure of the channel is distinguished by the
Scott Earley
exaly +3 more sources
Journal of Physiological SciencesTRPA1 was first identified as a noxious cold receptor in mice in 2003. Multiple TRPA1 genes have since been isolated, indicating that TRPA1 emerged early in evolution and showing the existence of TRPA1 variants in a range of species, including insects.
Makoto Tominaga
exaly +4 more sources
The Journal of Poultry Science, 2022 The pungency induced by spices and herbs plays an important role in food choice and appetite, and it is suggested that adding spices and herbs to feed as natural alternatives to antibiotics has beneficial effects in poultry farming.
Fuminori Kawabata +5 more
doaj +1 more source
Methylglyoxal evokes pain by stimulating TRPA1. [PDF]
PLoS ONE, 2013 Diabetic neuropathy is a severe complication of long-standing diabetes and one of the major etiologies of neuropathic pain. Diabetes is associated with an increased formation of reactive oxygen species and the electrophilic dicarbonyl compound ...
David A Andersson +7 more
doaj +1 more source
TRPA1: A Gatekeeper for Inflammation [PDF]
Annual Review of Physiology, 2013 Tissue damage evokes an inflammatory response that promotes the removal of harmful stimuli, tissue repair, and protective behaviors to prevent further damage and encourage healing. However, inflammation may outlive its usefulness and become chronic. Chronic inflammation can lead to a host of diseases, including asthma, itch, rheumatoid arthritis, and ...
Diana M, Bautista +2 more
openaire +2 more sources
Czech Journal of Animal Science, 2012 Thymol's antimicrobial properties urged researchers to study its effect on animal performance and intestinal health in pigs. However, thymol has the characteristic sharp odor of thyme and a bitter, aromatic, and sometimes burning sensation which may ...
J. Michiels +5 more
doaj +1 more source
Is Capsaicin a Pain Inducer or Killer? A Review of its Related Mechanisms [PDF]
المجلة العراقية للصيدلةBackground: Capsaicin is the chemical responsible for the hot and irritating characteristics of chili peppers. Because it produces both heat and pain, this phytochemical is a valuable means of scientific investment for pain research. Aim: This study
Ayman Faris Faisal +3 more
doaj +1 more source