ROS/TRPA1/CGRP signaling mediates cortical spreading depression [PDF]
The Journal of Headache and Pain, 2019 Objectives The transient receptor potential ankyrin A 1 (TRPA1) channel and calcitonin gene-related peptide (CGRP) are targets for migraine prophylaxis.
Liwen Jiang +3 more
doaj +5 more sources
TRPA1 channels in Drosophila and honey bee ectoparasitic mites share heat sensitivity and temperature-related physiological functions [PDF]
Frontiers in Physiology, 2016 The transient receptor potential cation channel, subfamily A, member 1 (TRPA1) is conserved between many arthropods, and in some has been shown to function as a chemosensor for noxious compounds.
Guangda Peng +5 more
doaj +3 more sources
Chronic alcohol consumption downregulates TRPA1 ion channel and the main peptidergic messengers of the Edinger-Westphal nucleus [PDF]
Scientific ReportsThe urocortin 1 (UCN1) and cocaine- and amphetamine-regulated transcript (CART) co-expressing neurons of the centrally projecting Edinger-Westphal nucleus (EWcp), regulate the function of reward- and addiction-related brain areas.
Ammar Al-Omari +11 more
doaj +2 more sources
The Journal of Poultry Science, 2022 The pungency induced by spices and herbs plays an important role in food choice and appetite, and it is suggested that adding spices and herbs to feed as natural alternatives to antibiotics has beneficial effects in poultry farming.
Fuminori Kawabata +5 more
doaj +1 more source
Methylglyoxal evokes pain by stimulating TRPA1. [PDF]
PLoS ONE, 2013 Diabetic neuropathy is a severe complication of long-standing diabetes and one of the major etiologies of neuropathic pain. Diabetes is associated with an increased formation of reactive oxygen species and the electrophilic dicarbonyl compound ...
David A Andersson +7 more
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TRPA1 as a O2 sensor detects microenvironmental hypoxia in the mice anterior cingulate cortex
Scientific Reports, 2023 Transient receptor potential ankyrin 1 (TRPA1) is a member of the TRP channel family and is expressed in peripheral and central nervous systems. In the periphery, TRPA1 senses cold and pain. However, the functions of TRPA1 in the CNS are unclear.
Ryo Kawabata +5 more
doaj +1 more source
Czech Journal of Animal Science, 2012 Thymol's antimicrobial properties urged researchers to study its effect on animal performance and intestinal health in pigs. However, thymol has the characteristic sharp odor of thyme and a bitter, aromatic, and sometimes burning sensation which may ...
J. Michiels +5 more
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Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. [PDF]
PLoS ONE, 2012 BACKGROUND: The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism.
Romina Nassini +15 more
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TRPA1 mediates aromatase inhibitor-evoked pain by the aromatase substrate androstenedione [PDF]
, 2016 Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are dependent upon the pain transducing receptor TRPA1. However, as the AI concentrations required to engage TRPA1 in mice are higher than those found in the plasma of ...
Benemei, Silvia +15 more
core +1 more source
Application of PASS Algorithm for the Discovery of New Trpa1 Antagonists
Proceedings, 2019 TRPA1 is a calcium ion channel found on the plasma membrane of many animal cells and it is [...]
Trif Comin +4 more
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