Results 1 to 10 of about 10,533 (140)

Function and therapeutic potential of transient receptor potential ankyrin 1 in fibrosis [PDF]

Frontiers in Pharmacology, 2022
The transient receptor potential (TRP) protein superfamily is a special group of cation channels expressed in different cell types and signaling pathways.
Yicheng Wei, Yicheng Wei, Yicheng Wei, Jialuo Cai, Jialuo Cai, Ruiqiu Zhu, Ruiqiu Zhu, Ke Xu, Ke Xu, Hongchang Li, Jianxin Li   +10 more
doaj   +4 more sources

Transient receptor potential ankyrin 1 in the knee is involved in osteoarthritis pain [PDF]

Biochemistry and Biophysics Reports, 2023
Transient receptor potential families play important roles in the pathology of osteoarthritis (OA) of the knee. While transient receptor potential ankyrin 1 (TRPA1) is also an essential component of the pathogenesis of various arthritic conditions, its ...
Hidenobu Tamai, Manabu Yamanaka, Wataru Taniguchi, Naoko Nishio, Daisuke Fukui, Terumasa Nakatsuka, Hiroshi Yamada   +6 more
doaj   +4 more sources

Transient Receptor Potential Ankyrin 1 Mediates Hypoxic Responses in Mice [PDF]

Frontiers in Physiology, 2020
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel that is broadly expressed in sensory pathways, such as the trigeminal and vagus nerves.
Sichong Chen, Sichong Chen, Nobuaki Takahashi, Nobuaki Takahashi, Changping Chen, Changping Chen, Jordan L. Pauli, Chiharu Kuroki, Chiharu Kuroki, Jun Kaminosono, Hideki Kashiwadani, Yuichi Kanmura, Yasuo Mori, Shaowu Ou, Liying Hao, Tomoyuki Kuwaki   +15 more
doaj   +5 more sources

The role of transient receptor potential ankyrin 1 in pyroptosis during pulpitis development [PDF]

BMC Oral Health
Background Vital pulp therapy has been a widely adopted for managing pulp diseases, in which the control of pulpitis progression is critical. Although the transient receptor potential ankyrin 1 (TRPA1) channel mediates pain transduction and inflammatory ...
Sixue Huang, Huihui Chang, Qinqi Zhang, Xinmin Liao, Ge Yang, Guicong Ding, Chanchan Chen   +6 more
doaj   +4 more sources

Local upregulation of transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 ion channels in rectosigmoid deep infiltrating endometriosis [PDF]

Molecular Pain, 2017
Transient Receptor Potential Vanilloid 1 (TRPV1) and Transient Receptor Potential Ankyrin 1 (TRPA1) expressed mainly by primary sensory neurons function as major nociceptive integrators.
Noémi Bohonyi, Krisztina Pohóczky, Bálint Szalontai, Anikó Perkecz, Krisztina Kovács, Béla Kajtár, Lajos Orbán, Tamás Varga, Sarolta Szegedi, József Bódis, Zsuzsanna Helyes, Miklós Koppán   +11 more
doaj   +4 more sources

Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as a Sensor of Oxidative Stress in Cancer Cells [PDF]

Cells, 2023
Moderate levels of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), fuel tumor metastasis and invasion in a variety of cancer types. Conversely, excessive ROS levels can impair tumor growth and metastasis by triggering cancer cell death ...
Francesco Moccia, Daniela Montagna
doaj   +4 more sources

Transient receptor potential Ankyrin 1: structure, function and ligands [PDF]

Research Results in Pharmacology, 2022
Introduction: Transient receptor potential ankyrin 1 (TRPA1) is a protein expressed in many living organisms. During the study of TRPA1, its unique biological role as a universal and polymodal sensor of various altering agents was found.
Natalia V. Pyatigorskaya, Olga V. Filippova, Natalia S. Nikolenko, Aleksey D. Kravchenko   +3 more
doaj   +6 more sources

Urate crystal induced inflammation and joint pain are reduced in transient receptor potential ankyrin 1 deficient mice--potential role for transient receptor potential ankyrin 1 in gout. [PDF]

PLoS ONE, 2015
INTRODUCTION:In gout, monosodium urate (MSU) crystals deposit intra-articularly and cause painful arthritis. In the present study we tested the hypothesis that Transient Receptor Poten-tial Ankyrin 1 (TRPA1), an ion channel mediating nociceptive signals ...
Lauri J Moilanen, Mari Hämäläinen, Lauri Lehtimäki, Riina M Nieminen, Eeva Moilanen   +4 more
doaj   +5 more sources

Transient receptor potential ankyrin 1 channel: An evolutionarily tuned thermosensor. [PDF]

Physiol Res, 2021
The discovery of the role of the transient receptor potential ankyrin 1 (TRPA1) channel as a polymodal detector of cold and pain-producing stimuli almost two decades ago catalyzed the consequent identification of various vertebrate and invertebrate orthologues.
Sinica V, Vlachová V.
europepmc   +3 more sources

Inhibition of transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 by mosquito and mouse saliva. [PDF]

Pain, 2022
Abstract Arthropods are the largest group of living organisms, and among them, mosquitoes spread parasites and viruses causing deadly diseases. They can easily spread these pathogens because of their painless skin piercing. Although the lack of pain is mainly due to the thinness of their fascicle, it is possible that mosquito saliva ...
Derouiche S, Li T, Sakai Y, Uta D, Aoyagi S, Tominaga M.   +5 more
europepmc   +4 more sources