Results 21 to 30 of about 28,002 (191)

Heat activation desensitizes Aedes aegypti transient receptor potential ankyrin 1 (AaTRPA1) to chemical agonists that repel mosquitoes. [PDF]

Pestic Biochem Physiol
Mosquito transient receptor potential ankyrin 1 (TRPA1) channels are nociceptors that can be activated by noxious heat and/or chemicals (e.g., electrophiles). When activated, TRPA1 channels typically trigger avoidance behaviors.
Park Y, Piermarini PM.
europepmc   +2 more sources

Discovery of BAY-390, a Selective CNS Penetrant Chemical Probe as Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonist. [PDF]

J Med Chem, 2023
Transient receptor potential ankyrin 1 (TRPA1) is a voltage-dependent, ligand-gated ion channel, and activation thereof is linked to a variety of painful conditions.
Mesch S, Walter D, Laux-Biehlmann A, Basting D, Flanagan S, Miyatake Ondozabal H, Bäurle S, Pearson C, Jenkins J, Elves P, Hess S, Coelho AM, Rotgeri A, Bothe U, Nawaz S, Zollner TM, Steinmeyer A.   +16 more
europepmc   +2 more sources

Canine, mouse, and human transient receptor potential ankyrin 1 (TRPA1) channels show different sensitivity to menthol or cold stimulation. [PDF]

J Vet Med Sci, 2023
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective cation channel that is activated by a variety of stimuli and acts as a nociceptor. Mouse and human TRPA1 exhibit different reactivity to some stimuli, including chemicals such as menthol as
Yamaguchi T, Uchida K, Yamazaki J.
europepmc   +2 more sources

Transient receptor potential Ankyrin-1 (TRPA1) agonists suppress myelination and induce demyelination in organotypic cortical slices. [PDF]

Glia, 2023
Oligodendrocytes are highly specialized glial cells characterized by their production of multilayer myelin sheaths that wrap axons to speed up action potential propagation.
Giacco V, Flower G, Artamonova M, Hunter J, Padilla Requerey A, Hamilton NB.   +5 more
europepmc   +2 more sources

Electrophilic Agonists Modulate the Transient Receptor Potential Ankyrin-1 Channels Mediated by Insulin and Glucagon-like Peptide-1 Secretion for Glucose Homeostasis. [PDF]

Pharmaceuticals (Basel), 2023
This pre-clinical study investigated the transient receptor potential ankyrin-1 (TRPA1) channels on modulating targets for glucose homeostasis using agonists: the electrophilic agonists, cinnamaldehyde (CIN) and allyl isothiocyanate (AITC), and the non ...
Frederico MJS, Cipriani A, Heim JBA, Mendes AKB, Aragón M, Gaspar JM, De Alencar NMN, Silva FRMB.   +7 more
europepmc   +2 more sources

Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses. [PDF]

Mol Med, 2023
Background Inflammation, the physiological response to infection and injury, is coordinated by the immune and nervous systems. Interleukin-1β (IL-1β) and other cytokines produced during inflammatory responses activate sensory neurons (nociceptors) to ...
Silverman HA, Tynan A, Hepler TD, Chang EH, Gunasekaran M, Li JH, Huerta TS, Tsaava T, Chang Q, Addorisio ME, Chen AC, Thompson DA, Pavlov VA, Brines M, Tracey KJ, Chavan SS.   +15 more
europepmc   +2 more sources

Role of transient receptor potential ankyrin 1 in idiopathic pulmonary fibrosis: modulation of M2 macrophage polarization. [PDF]

Cell Mol Life Sci
Idiopathic pulmonary fibrosis (IPF) poses significant challenges due to limited treatment options despite its complex pathogenesis involving cellular and molecular mechanisms.
Yang Y, Xiao Z, Yang W, Sun Y, Sui X, Lin X, Yang X, Bao Z, Cui Z, Ma Y, Li W, Wang S, Yang J, Wang Y, Luo Y.   +14 more
europepmc   +2 more sources

Desflurane Post-treatment Reduces Hypoxic-ischemic Brain Injury via Reducing Transient Receptor Potential Ankyrin 1 in Neonatal Rats. [PDF]

Neuroscience, 2023
Perinatal hypoxic-ischemic (HI) brain injury leads to mortality and morbidity in neonates and children. There are no effective and practical methods to attenuate this brain injury.
Zhou T, Li J, Cheng A, Zuo Z.
europepmc   +2 more sources

Transient Receptor Potential Ankyrin 1 Ion Channel Is Expressed in Osteosarcoma and Its Activation Reduces Viability. [PDF]

Int J Mol Sci
Osteosarcoma is a highly malignant, painful cancer with poor treatment opportunities and a bad prognosis. Transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are non-selective cation channels that have been of great interest ...
Hudhud L, Rozmer K, Kecskés A, Pohóczky K, Bencze N, Buzás K, Szőke É, Helyes Z.   +7 more
europepmc   +2 more sources

Transient receptor potential ankyrin 1 (TRPA1) mediates reactive oxygen species-induced Ca²⁺ entry, mitochondrial dysfunction, and caspase-3/7 activation in primary cultures of metastatic colorectal carcinoma cells. [PDF]

Cell Death Discov, 2023
Colorectal carcinoma (CRC) represents the fourth most common cancer worldwide and is the third most common cause of malignancy-associated mortality. Distant metastases to the liver and lungs are the main drivers of CRC-dependent death.
Faris P, Rumolo A, Pellavio G, Tanzi M, Vismara M, Berra-Romani R, Gerbino A, Corallo S, Pedrazzoli P, Laforenza U, Montagna D, Moccia F.   +11 more
europepmc   +2 more sources