Results 21 to 30 of about 111,852,927 (168)

Reactive oxygen species-specific characteristics of transient receptor potential ankyrin 1 receptor and its pain modulation [PDF]

Journal of Medicine and Life Science, 2023
Transient receptor potential ankyrin 1 (TRPA1) receptors are major polymodal nociceptors that generate primary pain responses in the peripheral nerve endings of the dorsal root ganglion neurons.
Hyun-Ji Yoon, Sung-Cherl Jung
doaj   +1 more source

The effect of allyl isothiocyanate on chondrocyte phenotype is matrix stiffness-dependent: Possible involvement of TRPA1 activation

Frontiers in Molecular Biosciences, 2023
Osteoarthritis (OA) is a chronic joint disease with increasing prevalence. Chondrocytes (CHs) are highly differentiated end-stage cells with a secretory phenotype that keeps the extracellular matrix (ECM) balanced and the cartilage environment stable ...
Hui Che, Zhiqiang Shao, Jiangchen Ding, Hua Gao, Xiangyu Liu, Hailong Chen, Shuangyu Cai, Jiaying Ge, Chengqiang Wang, Jun Wu, Yuefeng Hao   +10 more
doaj   +1 more source

Identification of Ligands for Chicken Transient Receptor Potential Ankyrin 1 Channel and Chemosensory Perception of Herbal Compounds in Chickens. [PDF]

J Poult Sci, 2022
The pungency induced by spices and herbs plays an important role in food choice and appetite, and it is suggested that adding spices and herbs to feed as natural alternatives to antibiotics has beneficial effects in poultry farming.
Kawabata F, Murayama K, Yoshida Y, Liang R, Nishimura S, Tabata S.   +5 more
europepmc   +2 more sources

Inhibition of Dorsal Root Ganglia Transient Receptor Potential Ankyrin 1 Upregulation Contributes to the Protective Effect of Morphine Against Gastric Mucosal Damage Induced by Water-Immersion Restraint Stress. [PDF]

Turk J Gastroenterol
Background/Aims: The pathogenesis mechanism of acute gastric mucosal lesions (AGML) is still unclear; further exploration is urgently needed to find a new therapeutic target.
Jiang Q, Jiang P, Guo M, Xie C, Ling Q, Zhao G, Tu W, Li X.   +7 more
europepmc   +2 more sources

Molecular Mechanisms of Dicentra Formosa’s Analgesic Effect

Medicine in Drug Discovery, 2020
Background: Surgeons, Native Americans, and Eclectics have all sworn to the multiple healing properties including anthelmintic, analgesic, and anti-cancer effects that Dicentra Formosa possesses.
Royale Gray-Lee, Jesun Lee
doaj   +1 more source

Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation

Frontiers in Pharmacology, 2021
Transient Receptor Potential (TRP) Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons, and integratively regulate nociceptor and inflammatory functions.
Ádám Horváth, Ádám Horváth, Maja Payrits, Maja Payrits, Anita Steib, Anita Steib, Boglárka Kántás, Boglárka Kántás, Tünde Biró-Süt, Tünde Biró-Süt, János Erostyák, János Erostyák, Géza Makkai, Géza Makkai, Éva Sághy, Éva Sághy, Éva Sághy, Zsuzsanna Helyes, Zsuzsanna Helyes, Éva Szőke, Éva Szőke   +20 more
doaj   +1 more source

sj-docx-1-npx-10.1177_1934578X231217942 - Supplemental material for Fluorescence Activity-Guided Isolation of Aaptamine Derivatives From the Marine Sponge Aaptos suberitoides and Their Inhibitory Activity Against Transient Receptor Potential Ankyrin 1

, 2023
Supplemental material, sj-docx-1-npx-10.1177_1934578X231217942 for Fluorescence Activity-Guided Isolation of Aaptamine Derivatives From the Marine Sponge Aaptos suberitoides and Their Inhibitory Activity Against Transient Receptor Potential Ankyrin 1 by ...
Jong Seok Lee (67521), Yeon-Ju Lee (1476295), Dan-Bi Sung (1676644), Kwiwan Jeong (17617401), Jung Mi Hyun (17617398), Myung Jin Song (8780570), Suhyun Kim (226047)   +6 more
core   +1 more source

Biochemical and structural insights into FIH-catalysed hydroxylation of transient receptor potential ankyrin repeat domains [PDF]

, 2023
Transient Receptor Potential (TRP) channels have important roles in environmental sensing in animals. Human TRP subfamily A member 1 (TRPA1) is responsible for sensing allyl isothiocyanate (AITC) and other electrophilic sensory irritants.

core   +1 more source

X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation

Molecular Pain, 2019
Radiotherapy-related pain is a common adverse reaction with a high incidence among cancer patients undergoing radiotherapy and remarkably reduces the quality of life. However, the mechanisms of ionizing radiation-induced pain are largely unknown. In this
Su Cun-Jin, Xu Jian-Hao, Liu Xu, Zhao Feng-Lun, Pan Jie, Shi Ai-Ming, Hu Duan-Min, Yu Yun-Li, Liu Tong, Zhang Yu-Song   +9 more
doaj   +1 more source

Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels

Nature Communications, 2022
Ultrasound can be used to non-invasively control neuronal functions. Here the authors report the use of human Transient receptor potential ankyrin 1 (hsTRPA1) to achieve ultrasound sensitivity in mammalian cells, and show that it can be used to ...
Marc Duque, Corinne A. Lee-Kubli, Yusuf Tufail, Uri Magaram, Janki Patel, Ahana Chakraborty, Jose Mendoza Lopez, Eric Edsinger, Aditya Vasan, Rani Shiao, Connor Weiss, James Friend, Sreekanth H. Chalasani   +12 more
doaj   +1 more source