Hydrogen Peroxide Induces Muscle Nociception via Transient Receptor Potential Ankyrin 1 Receptors [PDF]
Anesthesiology, 2017 Abstract Background H2O2 has a variety of actions in skin wounds but has been rarely studied in deep muscle tissue. Based on response to the transient receptor potential ankyrin 1 antagonists after plantar incision, we hypothesized that H2O2 exerts nociceptive effects via the transient receptor potential ankyrin 1 in ...
Daisuke, Sugiyama +5 more
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Journal of Pharmacological Sciences, 2020 Cellular dielectric spectroscopy (CDS) is a novel technology enabling pharmacological evaluation of multiple receptor types with a label-free cell-based assay.
Kanako Miyano +11 more
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Propofol Restores Transient Receptor Potential Vanilloid Receptor Subtype-1 Sensitivity via Activation of Transient Receptor Potential Ankyrin Receptor Subtype-1 in Sensory Neurons [PDF]
Anesthesiology, 2011 Background Cross talk between peripheral nociceptors belonging to the transient receptor potential vanilloid receptor subtype-1 (TRPV1) and ankyrin subtype-1 (TRPA1) family has been demonstrated recently. Moreover, the intravenous anesthetic propofol has directly activates TRPA1 receptors and indirectly restores
Hongyu, Zhang +4 more
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Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception
American Journal of Physiology-Cell Physiology, 2011 Transient receptor potential (TRP) ankyrin 1 (TRPA1) is a Ca2+-permeant, nonselective cationic channel. It is predominantly expressed in the C afferent sensory nerve fibers of trigeminal and dorsal root ganglion neurons and is highly coexpressed with the nociceptive ion channel transient receptor potential vanilloid 1 (TRPV1).
Manish, Raisinghani +8 more
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Characterization of a Ligand Binding Site in the Human Transient Receptor Potential Ankyrin 1 Pore [PDF]
Biophysical Journal, 2013 The pharmacology and regulation of Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel activity is intricate due to the physiological function as an integrator of multiple chemical, mechanical, and temperature stimuli as well as differences in species pharmacology.
Klement, Göran +7 more
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Transient Receptor Potential Ankyrin Type-1 Channels as a Potential Target for the Treatment of Cardiovascular Diseases [PDF]
Frontiers in Physiology, 2020 Cardiovascular disease is one of the chronic conditions with the highest mortality rate in the world. Underlying conditions such as hypertension, metabolic disorders, and habits like smoking are contributors to the manifestation of cardiovascular ...
Song Gao +8 more
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Inhibition of transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 by mosquito and mouse saliva. [PDF]
Pain, 2022 Abstract Arthropods are the largest group of living organisms, and among them, mosquitoes spread parasites and viruses causing deadly diseases. They can easily spread these pathogens because of their painless skin piercing. Although the lack of pain is mainly due to the thinness of their fascicle, it is possible that mosquito saliva ...
Derouiche S +5 more
europepmc +4 more sources
Transient receptor potential ankyrin 1 channel: An evolutionarily tuned thermosensor. [PDF]
Physiol Res, 2021 The discovery of the role of the transient receptor potential ankyrin 1 (TRPA1) channel as a polymodal detector of cold and pain-producing stimuli almost two decades ago catalyzed the consequent identification of various vertebrate and invertebrate orthologues.
Sinica V, Vlachová V.
europepmc +3 more sources
Transient receptor potential ankyrin 1 and calcium: Interactions and association with disease (Review). [PDF]
Exp Ther Med, 2021 Calcium (Ca2+) is an essential signaling molecule in all cells. It is involved in numerous fundamental functions, including cell life and death. Abnormal regulation of Ca2+ homeostasis may cause human diseases. Usually known as a member of the transient receptor potential (TRP) family, TRP ankyrin 1 (TRPA1) is the only member of the ankyrin subfamily ...
Hu F, Song X, Long D.
europepmc +3 more sources
Desflurane Post-treatment Reduces Hypoxic-ischemic Brain Injury via Reducing Transient Receptor Potential Ankyrin 1 in Neonatal Rats [PDF]
Neuroscience, 2023 Zhiyi Zuo, Aobing Cheng
exaly +2 more sources