Results 11 to 20 of about 37,224,805 (160)

Transient receptor potential Ankyrin 1: structure, function and ligands [PDF]

Research Results in Pharmacology, 2022
Introduction: Transient receptor potential ankyrin 1 (TRPA1) is a protein expressed in many living organisms. During the study of TRPA1, its unique biological role as a universal and polymodal sensor of various altering agents was found.
Natalia V. Pyatigorskaya, Olga V. Filippova, Natalia S. Nikolenko, Aleksey D. Kravchenko   +3 more
doaj   +8 more sources

Urate crystal induced inflammation and joint pain are reduced in transient receptor potential ankyrin 1 deficient mice--potential role for transient receptor potential ankyrin 1 in gout. [PDF]

PLoS ONE, 2015
INTRODUCTION:In gout, monosodium urate (MSU) crystals deposit intra-articularly and cause painful arthritis. In the present study we tested the hypothesis that Transient Receptor Poten-tial Ankyrin 1 (TRPA1), an ion channel mediating nociceptive signals ...
Lauri J Moilanen, Mari Hämäläinen, Lauri Lehtimäki, Riina M Nieminen, Eeva Moilanen   +4 more
doaj   +7 more sources

Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function [PDF]

Cells, 2021
TRPA1 (transient receptor potential ankyrin 1), the lone member of the mammalian ankyrin TRP subfamily, is a Ca2+-permeable, non-selective cation channel.
Michael G. Alvarado, Pratish Thakore, Scott Earley   +2 more
doaj   +4 more sources

Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. [PDF]

PLoS ONE, 2011
Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic ...
Andreas Binder, Denisa May, Ralf Baron, Christoph Maier, Thomas R Tölle, Rolf-Detlef Treede, Achim Berthele, Frank Faltraco, Herta Flor, Janne Gierthmühlen, Sierk Haenisch, Volker Huge, Walter Magerl, Christian Maihöfner, Helmut Richter, Roman Rolke, Andrea Scherens, Nurcan Uçeyler, Mike Ufer, Gunnar Wasner, Jihong Zhu, Ingolf Cascorbi   +21 more
doaj   +4 more sources

Transient Receptor Potential Ankyrin 1 (TRPA1) Channel Mediates Acrolein Cytotoxicity in Human Lung Cancer Cells [PDF]

International Journal of Molecular Sciences, 2023
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective ion channel implicated in thermosensation and inflammatory pain. It has been reported that expression of the TRPA1 channel is induced by cigarette smoke extract. Acrolein found in cigarette
Akihiko Sakamoto, Yusuke Terui, Kazuei Igarashi   +2 more
exaly   +3 more sources

Transient Receptor Potential Ankyrin 1 (TRPA1)—An Inflammation-Induced Factor in Human HaCaT Keratinocytes [PDF]

International Journal of Molecular Sciences, 2021
Transient receptor potential ankyrin 1 (TRPA1) is an ion channel mainly studied in sensory neurons where it mediates itch, pain and neurogenic inflammation.
Samu Luostarinen, Mari Hämäläinen, Eeva Moilanen   +2 more
exaly   +3 more sources

Muscle pain induced by static contraction is modulated by transient receptor potential vanilloid 1 and ankyrin 1 receptors

Brazilian Journal of Pharmaceutical Sciences, 2022
Molecular mechanisms involved in the development of muscle pain induced by static contraction are not completely elucidated. This study aimed to evaluate the involvement of the transient receptor potential vanilloid 1 (TRPV1) and the transient receptor ...
Carolina Ocanha Jorge, Bruna de Melo-Aquino, Diogo Francisco da Silva dos Santos, Maria Cláudia Gonçalves de Oliveira   +3 more
doaj   +3 more sources

Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists

Pharmaceutical Patent Analyst, 2015
The transient receptor potential ankyrin 1 (TRPA1) channel is an irritant sensor highly expressed on nociceptive neurons. The clinical use of TRPA1 antagonists is based on the concept that TRPA1 is active during disease states like neuropathic pain.
PRETI, Delia, SAPONARO, Giulia, Szallasi, Arpad   +2 more
openaire   +4 more sources

Transient receptor potential ankyrin receptor 1 is a novel target for pro‐tussive agents [PDF]

British Journal of Pharmacology, 2009
Background and purpose: The transient receptor potential ankyrin receptor 1 (TRPA1) is a cation channel, co‐expressed with the pro‐tussive transient receptor potential vanilloid type 1 (TRPV1) channel in primary sensory neurons. TRPA1 is activated by a series of irritant exogenous and endogenous α,β‐unsaturated aldehydes which seem to play a role in ...
Andre E., Gatti R., TREVISANI, Marcello, PRETI, Delia, BARALDI, Pier Giovanni, Patacchini R., Geppetti P.   +6 more
core   +5 more sources

Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. [PDF]

PLoS ONE, 2012
BACKGROUND: The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism.
Romina Nassini, Pamela Pedretti, Nadia Moretto, Camilla Fusi, Chiara Carnini, Fabrizio Facchinetti, Arturo Roberto Viscomi, Anna Rita Pisano, Susan Stokesberry, Charlott Brunmark, Naila Svitacheva, Lorcan McGarvey, Riccardo Patacchini, Anders B Damholt, Pierangelo Geppetti, Serena Materazzi   +15 more
doaj   +3 more sources