Regulation of transient receptor potential ankyrin 1 by traditional Chinese medicine drugs and their active ingredients [PDF]
Frontiers in PharmacologyTransient receptor potential ankyrin 1 (TRPA1) has attracted substantial attention for its role as a thermal receptor and regulator of temperature and pain sensing.
Yunlong Fang +17 more
doaj +3 more sources
Transient receptor potential ankyrin 1 and calcium: Interactions and association with disease (Review). [PDF]
Exp Ther Med, 2021 Calcium (Ca2+) is an essential signaling molecule in all cells. It is involved in numerous fundamental functions, including cell life and death. Abnormal regulation of Ca2+ homeostasis may cause human diseases. Usually known as a member of the transient receptor potential (TRP) family, TRP ankyrin 1 (TRPA1) is the only member of the ankyrin subfamily ...
Hu F, Song X, Long D.
europepmc +4 more sources
Toll-like receptor 4 signaling pathway in sensory neurons mediates remifentanil-induced postoperative hyperalgesia via transient receptor potential ankyrin 1 [PDF]
Molecular Pain, 2023 Background: Remifentanil-induced postoperative hyperalgesia (RIH) refers to a state of hyperalgesia or aggravated pre-existing pain after remifentanil exposure. There has been considerable interest in understanding and preventing RIH.
Xiaowen Liu +3 more
doaj +3 more sources
Lack of transient receptor potential ankyrin 1 (TRPA1) retards cutaneous wound healing in mice: A preliminary study [PDF]
Biochemistry and Biophysics Reports, 2022 Wound healing is an important process in various diseases, and elucidating the underlying mechanism is essential for developing therapeutic strategies.
Shizumasa Murata +8 more
doaj +3 more sources
Transient Receptor Potential Ankyrin 1 (TRPA1) Channel Mediates Acrolein Cytotoxicity in Human Lung Cancer Cells [PDF]
International Journal of Molecular Sciences, 2023 Transient receptor potential ankyrin 1 (TRPA1) is a nonselective ion channel implicated in thermosensation and inflammatory pain. It has been reported that expression of the TRPA1 channel is induced by cigarette smoke extract. Acrolein found in cigarette
Akihiko Sakamoto +2 more
exaly +3 more sources
Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function [PDF]
Cells, 2021 TRPA1 (transient receptor potential ankyrin 1), the lone member of the mammalian ankyrin TRP subfamily, is a Ca2+-permeable, non-selective cation channel.
Michael G. Alvarado +2 more
doaj +3 more sources
Transient Receptor Potential Ankyrin 1 (TRPA1)—An Inflammation-Induced Factor in Human HaCaT Keratinocytes [PDF]
International Journal of Molecular Sciences, 2021 Transient receptor potential ankyrin 1 (TRPA1) is an ion channel mainly studied in sensory neurons where it mediates itch, pain and neurogenic inflammation.
Samu Luostarinen +2 more
exaly +3 more sources
Frontiers in Pharmacology, 2021 Transient Receptor Potential (TRP) Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons, and integratively regulate nociceptor and inflammatory functions.
Ádám Horváth +20 more
doaj +2 more sources
Transient Receptor Potential Ankyrin Type-1 Channels as a Potential Target for the Treatment of Cardiovascular Diseases [PDF]
Frontiers in Physiology, 2020 Cardiovascular disease is one of the chronic conditions with the highest mortality rate in the world. Underlying conditions such as hypertension, metabolic disorders, and habits like smoking are contributors to the manifestation of cardiovascular ...
Song Gao +8 more
doaj +3 more sources
Transient Receptor Potential Ankyrin 1 Channels in Inflammation and Cancer: Accelerators or Brakes? [PDF]
Function, 2022 Shuang Peng
doaj +2 more sources