Transient receptor potential ankyrin 1 ion channel expressed by the Edinger-Westphal nucleus contributes to stress adaptation in murine model of posttraumatic stress disorder. [PDF]
Front Cell Dev Biol, 2022 The centrally projecting Edinger-Westphal nucleus (EWcp) is involved in stress adaptation. Transient receptor potential ankyrin 1 (TRPA1) mRNA was previously shown to be expressed abundantly in mouse and human EWcp urocortin 1 (UCN1) positive neurons and
Konkoly J +7 more
europepmc +2 more sources
Etodolac activates and desensitizes transient receptor potential ankyrin 1 [PDF]
Journal of Neuroscience Research, 2013 The transient receptor potential ankyrin 1 (TRPA1) channel is well known as a sensor to environmental irritant compounds, cold, and endogenous proalgesic agents. TRPA1 is expressed on sensory neurons and is involved in pain modulation. Etodolac is a cyclooxygenase (COX)‐2 inhibitor that belongs to the class of nonsteroidal anti‐inflammatory drugs ...
Shenglan, Wang +5 more
openaire +2 more sources
Activation of transient receptor potential ankyrin 1 by quercetin and its analogs [PDF]
Bioscience, Biotechnology, and Biochemistry, 2016 Abstract The agonistic activity of quercetin and its analogs towards the transient receptor potential ankyrin 1 (TRPA1) has been experimentally investigated. The human TRPA1 was expressed in HEK293T cells using a tetracycline-inducible system.
Toshiyuki, Nakamura +5 more
openaire +2 more sources
Knockout of transient receptor potential ankyrin 1 (TRPA1) modulates the glial phenotype and alleviates perihematomal neuroinflammation after intracerebral hemorrhage in mice via MAPK/NF-κB signaling. [PDF]
Neuroreport, 2023 The objective is to explore the role of astrocytic transient receptor potential ankyrin 1 (TRPA1) in glial phenotype transformation in neuroinflammation after intracerebral hemorrhage (ICH).
Xia M +10 more
europepmc +2 more sources
The Hypothermic Effect of Hydrogen Sulfide Is Mediated by the Transient Receptor Potential Ankyrin-1 Channel in Mice. [PDF]
Pharmaceuticals (Basel), 2021 Hydrogen sulfide (H2S) has been shown in previous studies to cause hypothermia and hypometabolism in mice, and its thermoregulatory effects were subsequently investigated.
Olah E +14 more
europepmc +2 more sources
Role of transient receptor potential ankyrin 1 channels in Alzheimer’s disease [PDF]
Journal of Neuroinflammation, 2016 Transient receptor potential ankyrin 1 (TRPA1) channel plays an important role in pain and inflammation. However, little is known about the significance of the TRPA1 channel in the pathophysiology of Alzheimer's disease (AD).Wild-type (WT), TRPA1(-/-), amyloid precursor protein (APP)/presenilin 1 (PS1) transgenic (APP/PS1 Tg) mice, the mouse model of ...
Lee, Kuan-I +6 more
openaire +2 more sources
Transient receptor potential ankyrin receptor 1 is a novel target for pro‐tussive agents [PDF]
British Journal of Pharmacology, 2009 Background and purpose: The transient receptor potential ankyrin receptor 1 (TRPA1) is a cation channel, co‐expressed with the pro‐tussive transient receptor potential vanilloid type 1 (TRPV1) channel in primary sensory neurons. TRPA1 is activated by a series of irritant exogenous and endogenous α,β‐unsaturated aldehydes which seem to play a role in ...
Andre E. +6 more
openaire +4 more sources
Molecular Mechanisms of Dicentra Formosa’s Analgesic Effect
Medicine in Drug Discovery, 2020 Background: Surgeons, Native Americans, and Eclectics have all sworn to the multiple healing properties including anthelmintic, analgesic, and anti-cancer effects that Dicentra Formosa possesses.
Royale Gray-Lee, Jesun Lee
doaj +1 more source
Pain, 2021 Supplemental Digital Content is Available in the Text. A transient receptor potential ankyrin 1 antagonist (ISC 17536) was evaluated for efficacy and safety in patients with chronic, painful diabetic peripheral neuropathy.
Sunil M. Jain +8 more
semanticscholar +1 more source
New natural agonists of the transient receptor potential Ankyrin 1 (TRPA1) channel [PDF]
Scientific Reports, 2020 AbstractThe transient receptor potential (TRP) channels family are cationic channels involved in various physiological processes as pain, inflammation, metabolism, swallowing function, gut motility, thermoregulation or adipogenesis. In the oral cavity, TRP channels are involved in chemesthesis, the sensory chemical transduction of spicy ingredients ...
Legrand, Coline +3 more
openaire +2 more sources