Activation of transient receptor potential ankyrin 1 by quercetin and its analogs [PDF]
Bioscience, Biotechnology, and Biochemistry, 2016 Abstract The agonistic activity of quercetin and its analogs towards the transient receptor potential ankyrin 1 (TRPA1) has been experimentally investigated. The human TRPA1 was expressed in HEK293T cells using a tetracycline-inducible system.
Toshiyuki, Nakamura +5 more
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X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation
Molecular Pain, 2019 Radiotherapy-related pain is a common adverse reaction with a high incidence among cancer patients undergoing radiotherapy and remarkably reduces the quality of life. However, the mechanisms of ionizing radiation-induced pain are largely unknown. In this
Su Cun-Jin +9 more
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Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels
Nature Communications, 2022 Ultrasound can be used to non-invasively control neuronal functions. Here the authors report the use of human Transient receptor potential ankyrin 1 (hsTRPA1) to achieve ultrasound sensitivity in mammalian cells, and show that it can be used to ...
Marc Duque +12 more
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β-III spectrin underpins ankyrin R function in Purkinje cell dendritic trees:Protein complex critical for sodium channel activity is impaired by SCA5-associated mutations [PDF]
, 2014 Beta III spectrin is present throughout the elaborate dendritic tree of cerebellar Purkinje cells and is required for normal neuronal morphology and cell survival.
Perkins, Emma M. +6 more
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The role of transient receptor potential ankyrin 1 in age-related endothelial dysfunction
Experimental Gerontology, 2021 Oxidative stress plays a key role in age-related vascular disease. The present study aimed to investigate the role of an antioxidant channel, transient receptor potential ankyrin 1 (TRPA1), in age-related endothelial dysfunction. Human umbilical vein endothelial cells (HUVECs) were grown to induce replicative senescence, and 6-month-old young, 12-month-
Yi, Yang +10 more
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Regulation of vascular tone by transient receptor potential ankyrin 1 channels
, 2020 The Ca2+-permeable, non-selective cation channel, TRPA1 (transient receptor potential ankyrin 1), is the sole member of the ankyrin TRP subfamily. TRPA1 channels are expressed on the plasma membrane of neurons as well as non-neuronal cell types, such as vascular endothelial cells.
Pratish, Thakore +2 more
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Biochemical and structural insights into FIH-catalysed hydroxylation of transient receptor potential ankyrin repeat domains [PDF]
, 2022 Transient Receptor Potential (TRP) channels have important roles in environmental sensing in animals. Human TRP subfamily A member 1 (TRPA1) is responsible for sensing allyl isothiocyanate (AITC) and other electrophilic sensory irritants.
Saward, Benjamin +6 more
core +1 more source
Scientific Reports, 2021 The transient receptor potential ankyrin type 1 (TRPA1) channel belongs to the TRP superfamily of ion channels. TRPA1 is a membrane protein with multiple functions able to respond to noxious stimuli, reactive oxygen species, inflammatory cytokines or ...
Florentina Cojocaru +9 more
doaj +1 more source
Molecular Pain, 2007 Agonists of TRPA1 such as mustard oil and its key component AITC cause pain and neurogenic inflammation in humans and pain behavior in rodents. TRPA1 is activated by numerous reactive compounds making it a sensor for reactive compounds in the body ...
Immke David C +6 more
doaj +1 more source
Transient receptor potential ankyrin 1 contributes to somatic pain hypersensitivity in experimental colitis [PDF]
Scientific Reports, 2020 AbstractPain evoked by visceral inflammation is often ‘referred’ to the somatic level. Transient receptor potential ankyrin 1 (TRPA1) has been reported to contribute to visceral pain-like behavior in dextran sulfate sodium (DSS)-evoked colitis. However, the role of TRPA1 in somatic component of hypersensitivity due to visceral inflammation is unknown ...
1. Jain P. +10 more
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