Results 61 to 70 of about 37,224,805 (160)

Role of Transient Receptor Potential Ankyrin 1 Ion Channel and Somatostatin sst4 Receptor in the Antinociceptive and Anti-inflammatory Effects of Sodium Polysulfide and Dimethyl Trisulfide

Frontiers in Endocrinology, 2018
Transient receptor potential ankyrin 1 (TRPA1) non-selective ligand-gated cation channels are mostly expressed in primary sensory neurons. Polysulfides (POLYs) are Janus-faced substances interacting with numerous target proteins and associated with both ...
István Z. Bátai, Ádám Horváth, Erika Pintér, Zsuzsanna Helyes, Gábor Pozsgai   +4 more
doaj   +1 more source

Stilbenoid compounds inhibit NF-κB-mediated inflammatory responses in the Drosophila intestine

Frontiers in Immunology, 2023
IntroductionStilbenoid compounds have been described to have anti-inflammatory properties in animal models in vivo, and have been shown to inhibit Ca2+-influx through the transient receptor potential ankyrin 1 (TrpA1).MethodsTo study how stilbenoid ...
Anna L. Aalto, Anna L. Aalto, Atefeh Saadabadi, Atefeh Saadabadi, Atefeh Saadabadi, Fanny Lindholm, Christa Kietz, Emmy Himmelroos, Parthiban Marimuthu, Parthiban Marimuthu, Outi M. H. Salo-Ahen, Outi M. H. Salo-Ahen, Patrik Eklund, Annika Meinander, Annika Meinander   +14 more
doaj   +1 more source

PP272—Migraine and parthenolide inhibition of transient receptor potential ankyrin 1 [PDF]

Clinical Therapeutics, 2013
2013 e103 emerged as a major complication of bortezomib therapy, which usually appears in the first courses of therapy with a number of sensory and painful symptoms, including reduced threshold to mechanical and cold stimuli. No satisfactory explanation or effective treatment exists for bortezomib-evoked CIPN.
Materazzi, S., Benemei, S., Fusi, C., De Siena, G., Trevisan dos Santos, G., Dussor, G., Pollastro, F., Patacchini, R., Appendino, G., Geppetti, P., Nassini, R.   +10 more
openaire   +2 more sources

Cytoplasmic Ankyrin Repeats of Transient Receptor Potential A1 (TRPA1) Dictate Sensitivity to Thermal and Chemical Stimuli [PDF]

, 2011
Transient receptor potential (TRP) channels are polymodal signal detectors that respond to a wide array of physical and chemical stimuli, making them important components of sensory systems in both vertebrate and invertebrate organisms ...
Cordero-Morales, Julio F., Julio F. Cordero-Morales, Gracheva, Elena O., Elena O. Gracheva, Julius, David, David Julius   +5 more
core   +1 more source

Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS

Nature Communications, 2016
The transient receptor potential ankyrin 1 (TRPA1) is a cation channel that is involved in nociceptive pain sensing. Here, the authors show that hydroxylation of a proline in the N terminus of TRPA1 renders it sensitive to reactive oxygen species ...
Takahito Miyake, Saki Nakamura, Meng Zhao, Kanako So, Keisuke Inoue, Tomohiro Numata, Nobuaki Takahashi, Hisashi Shirakawa, Yasuo Mori, Takayuki Nakagawa, Shuji Kaneko   +10 more
doaj   +1 more source

Different Involvement of ASIC and TRPA1 in Facial and Hindpaw Allodynia in Nitroglycerin-Induced Peripheral Hypersensitivities in Mice

Life, 2022
The pathophysiological mechanism underlying migraine-associated peripheral hypersensitivity remains unclear. Acid-sensing ion channels (ASICs) and transient receptor potential ankyrin 1 (TRPA1) are known to be causative pathogenic factors of mechanical ...
Sol-Ji Kim, Ji-Hee Yeo, Seo-Yeon Yoon, Dae-Hyun Roh   +3 more
doaj   +1 more source

Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells

Cells, 2014
Transient receptor potential (TRP) ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are implicated in modulation of cough and nociception. In vivo, TRPA1 and TRPV1 are often co-expressed in neurons and TRPA1V1 hetero-tetramer formation is noted in ...
Laura R. Sadofsky, Koti T. Sreekrishna, Yakang Lin, Renee Schinaman, Kate Gorka, Yogita Mantri, John Christian Haught, Thomas G. Huggins, Robert J. Isfort, Charles C. Bascom, Alyn H. Morice   +10 more
doaj   +1 more source

Publisher Correction: Functional expression of the transient receptor potential ankyrin type 1 channel in pancreatic adenocarcinoma cells

Scientific Reports, 2021
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Florentina Cojocaru, Tudor Şelescu, Dan Domocoş, Luminiţa Măruţescu, Gabriela Chiritoiu, Nicoleta-Raluca Chelaru, Simona Dima, Dan Mihăilescu, Alexandru Babes, Dana Cucu   +9 more
doaj   +1 more source

The push-to-open mechanism of the tethered mechanosensitive ion channel NompC

eLife, 2021
NompC is a mechanosensitive ion channel responsible for the sensation of touch and balance in Drosophila melanogaster. Based on a resolved cryo-EM structure, we performed all-atom molecular dynamics simulations and electrophysiological experiments to ...
Yang Wang, Yifeng Guo, Guanluan Li, Chunhong Liu, Lei Wang, Aihua Zhang, Zhiqiang Yan, Chen Song   +7 more
doaj   +1 more source

Development of the G3 Designed ankyrin repeat protein (DARPin) for HER2 imaging [PDF]

, 2015
Background: Human epidermal growth factor receptor-2 (HER2) expression predicts response to anti-HER2 therapy in breast and gastric cancer. HER2 status is assessed by tumour biopsy but this may not be representative of the larger tumour mass or other ...
Goldstein, RM
core