Results 51 to 60 of about 28,002 (191)
The role of transient receptor potential ankyrin 1 in age-related endothelial dysfunction
Experimental Gerontology, 2021 Oxidative stress plays a key role in age-related vascular disease. The present study aimed to investigate the role of an antioxidant channel, transient receptor potential ankyrin 1 (TRPA1), in age-related endothelial dysfunction. Human umbilical vein endothelial cells (HUVECs) were grown to induce replicative senescence, and 6-month-old young, 12-month-
Yi, Yang +10 more
openaire +2 more sources
X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation
Molecular Pain, 2019 Radiotherapy-related pain is a common adverse reaction with a high incidence among cancer patients undergoing radiotherapy and remarkably reduces the quality of life. However, the mechanisms of ionizing radiation-induced pain are largely unknown. In this
Su Cun-Jin +9 more
doaj +1 more source
Journal of Pharmacological Sciences, 2020 Cellular dielectric spectroscopy (CDS) is a novel technology enabling pharmacological evaluation of multiple receptor types with a label-free cell-based assay.
Kanako Miyano +11 more
doaj +1 more source
Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels
Nature Communications, 2022 Ultrasound can be used to non-invasively control neuronal functions. Here the authors report the use of human Transient receptor potential ankyrin 1 (hsTRPA1) to achieve ultrasound sensitivity in mammalian cells, and show that it can be used to ...
Marc Duque +12 more
doaj +1 more source
Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. [PDF]
PLoS ONE, 2012 BACKGROUND: The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism.
Romina Nassini +15 more
doaj +1 more source
Neurourology and Urodynamics, 2023 This study aimed to investigate whether pathways involving transient receptor potential ankyrin 1 (TRPA1) channels in the urinary bladder mediate the bladder overactivity elicited by exposure to a low temperature in rats.
Tetsuya Imamura +7 more
semanticscholar +1 more source
Brazilian Journal of Pharmaceutical Sciences, 2022 Molecular mechanisms involved in the development of muscle pain induced by static contraction are not completely elucidated. This study aimed to evaluate the involvement of the transient receptor potential vanilloid 1 (TRPV1) and the transient receptor ...
Carolina Ocanha Jorge +3 more
doaj +1 more source
Genetic and functional evidence for gp130/IL6ST-induced transient receptor potential ankyrin 1 upregulation in uninjured but not injured neurons in a mouse model of neuropathic pain. [PDF]
Pain, 2022 gp130 is a critically important regulator of mechanical hypersensitivity after nerve injury. Transient receptor potential ankyrin 1-responsiveness is upregulated after spared nerve injury in uninjured but not injured neurons.
Kalpachidou T +7 more
europepmc +2 more sources
Scientific Reports, 2021 The transient receptor potential ankyrin type 1 (TRPA1) channel belongs to the TRP superfamily of ion channels. TRPA1 is a membrane protein with multiple functions able to respond to noxious stimuli, reactive oxygen species, inflammatory cytokines or ...
Florentina Cojocaru +9 more
doaj +1 more source
Regulation of vascular tone by transient receptor potential ankyrin 1 channels
, 2020 The Ca2+-permeable, non-selective cation channel, TRPA1 (transient receptor potential ankyrin 1), is the sole member of the ankyrin TRP subfamily. TRPA1 channels are expressed on the plasma membrane of neurons as well as non-neuronal cell types, such as vascular endothelial cells.
Pratish, Thakore +2 more
openaire +3 more sources