Results 51 to 60 of about 37,224,805 (160)

Functional Transient Receptor Potential Ankyrin 1 and Vanilloid 1 Ion Channels Are Overexpressed in Human Oral Squamous Cell Carcinoma. [PDF]

Int J Mol Sci, 2022
Oral squamous cell carcinoma (OSCC) is a common cancer with poor prognosis. Transient Receptor Potential Ankyrin 1 (TRPA1) and Vanilloid 1 (TRPV1) receptors are non-selective cation channels expressed on primary sensory neurons and epithelial and immune ...
Kiss F, Kormos V, Szőke É, Kecskés A, Tóth N, Steib A, Szállási Á, Scheich B, Gaszner B, Kun J, Fülöp G, Pohóczky K, Helyes Z.   +12 more
europepmc   +2 more sources

Activation of Myofibroblast TRPA1 by Steroids and Pirfenidone Ameliorates Fibrosis in Experimental Crohn's Disease

Cellular and Molecular Gastroenterology and Hepatology, 2018
The transient receptor potential ankyrin 1 (TRPA1) channel is highly expressed in the intestinal lamina propria, but its contribution to gut physiology/pathophysiology is unclear.
Lin Hai Kurahara, Keizo Hiraishi, Yaopeng Hu, Kaori Koga, Miki Onitsuka, Mayumi Doi, Kunihiko Aoyagi, Hidetoshi Takedatsu, Daibo Kojima, Yoshitaka Fujihara, Yuwen Jian, Ryuji Inoue   +11 more
doaj   +1 more source

Methylglyoxal activates the human transient receptor potential ankyrin 1 channel

The Journal of Toxicological Sciences, 2012
Methylglyoxal (MG) is an endogenous carbonyl compound that is produced in large quantity under hyperglycemic conditions, which are believed to contribute to the development of diabetic neuropathy. However, the mechanism by which this occurs and the molecular targets of MG are unclear.
Ohkawara, Susumu, Tanaka-Kagawa, Toshiko, Furukawa, Yoko, Jinno, Hideto   +3 more
openaire   +2 more sources

Investigation of Cuprizone-Induced Demyelination in mGFAP-Driven Conditional Transient Receptor Potential Ankyrin 1 (TRPA1) Receptor Knockout Mice

Cells, 2019
Transient receptor potential ankyrin 1 (TRPA1) receptors are non-selective cation channels responsive to a variety of exogenous irritants and endogenous stimuli including products of oxidative stress.
Gábor Kriszta, Balázs Nemes, Zoltán Sándor, Péter Ács, Sámuel Komoly, Zoltán Berente, Kata Bölcskei, Erika Pintér   +7 more
doaj   +1 more source

Ligands Exert Biased Activity to Regulate Sigma 1 Receptor Interactions With Cationic TRPA1, TRPV1, and TRPM8 Channels

Frontiers in Pharmacology, 2019
The sigma 1 receptor (σ1R) and the mu-opioid receptor (MOR) regulate the transient receptor potential (TRP) V1 calcium channel. A series of proteins are involved in the cross-regulation between MORs and calcium channels like the glutamate N-methyl-D ...
Elsa Cortés-Montero, Pilar Sánchez-Blázquez, Yara Onetti, Manuel Merlos, Javier Garzón   +4 more
doaj   +1 more source

sj-docx-1-npx-10.1177_1934578X231217942 - Supplemental material for Fluorescence Activity-Guided Isolation of Aaptamine Derivatives From the Marine Sponge Aaptos suberitoides and Their Inhibitory Activity Against Transient Receptor Potential Ankyrin 1

, 2023
Supplemental material, sj-docx-1-npx-10.1177_1934578X231217942 for Fluorescence Activity-Guided Isolation of Aaptamine Derivatives From the Marine Sponge Aaptos suberitoides and Their Inhibitory Activity Against Transient Receptor Potential Ankyrin 1 by ...
Jong Seok Lee (67521), Yeon-Ju Lee (1476295), Dan-Bi Sung (1676644), Kwiwan Jeong (17617401), Jung Mi Hyun (17617398), Myung Jin Song (8780570), Suhyun Kim (226047)   +6 more
core   +1 more source

Expression of Transient Receptor Potential Ankyrin 1 and Transient Receptor Potential Vanilloid 1 in the Gut of the Peri-Weaning Pig Is Strongly Dependent on Age and Intestinal Site

Animals, 2020
Transient receptor potential (TRP) channels contribute to sensory transduction in the body, agonized by a variety of stimuli, such as phytochemicals, and they are predominantly distributed in afferent neurons.
Elout Van Liefferinge, Noémie Van Noten, Jeroen Degroote, Gunther Vrolix, Mario Van Poucke, Luc Peelman, Chris Van Ginneken, Eugeni Roura, Joris Michiels   +8 more
doaj   +1 more source

The Calcium Channel α2δ1 Subunit: Interactional Targets in Primary Sensory Neurons and Role in Neuropathic Pain

Frontiers in Cellular Neuroscience, 2021
Neuropathic pain is mainly triggered after nerve injury and associated with plasticity of the nociceptive pathway in primary sensory neurons. Currently, the treatment remains a challenge. In order to identify specific therapeutic targets, it is necessary
Wenqiang Cui, Hongyun Wu, Xiaowen Yu, Ting Song, Xiangqing Xu, Fei Xu   +5 more
doaj   +1 more source

Envolvimento do receptor de potencial transitório A1 (TRPA1) na manutenção da hiperalgesia mecânica e térmica (Frio) na inflamação persistente [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Farmacologia, Florianópolis, 2010O presente estudo investiga o papel do receptor TRPA1 no esenvolvimento e manutenção da ...
Costa, Diogo Santos Martins da
core  

‐induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1

, 2013
The underlying mechanisms of itch are poorly understood. We have investigated a model involving the chemoattractant leukotriene B4 (LTB4) that is up-regulated in common skin diseases.
Bodkin, Jennifer V., Salma Awal, Aisah A. Aubdool, Richard Heads, Vong, Chi Teng, Quek, Samuel, Liang, Lihuan, Fernandes, Elizabeth S., Brain, Susan D.; id_orcid, Clive Gentry, Stuart Bevan, Bevan, Stuart; id_orcid, Awal, Salma, Gentry, Clive; id_orcid, Chi Teng Vong, Lihuan Liang, Jennifer V. Bodkin, Aubdool, Aisah, Jessica Cheong, Cheong, Jessica, Elizabeth S. Fernandes, Samuel Quek, Heads, Richard, Susan D. Brain   +23 more
core   +1 more source