Results 31 to 40 of about 28,002 (191)

Dual role of transient receptor potential ankyrin 1 in respiratory and gastrointestinal physiology: From molecular mechanisms to therapeutic targets. [PDF]

Front Physiol
The transient receptor potential ankyrin 1 (TRPA1) channel plays a pivotal role in the respiratory and gastrointestinal tracts. Within the respiratory system, TRPA1 exhibits diverse distribution patterns across key cell types, including epithelial cells,
Tekulapally KR, Lee JY, Kim DS, Rahman MM, Park CK, Kim YH.   +5 more
europepmc   +2 more sources

Reactive oxygen species-specific characteristics of transient receptor potential ankyrin 1 receptor and its pain modulation [PDF]

Journal of Medicine and Life Science, 2023
Transient receptor potential ankyrin 1 (TRPA1) receptors are major polymodal nociceptors that generate primary pain responses in the peripheral nerve endings of the dorsal root ganglion neurons.
Hyun-Ji Yoon, Sung-Cherl Jung
doaj   +1 more source

Transient Receptor Potential Ankyrin 1 (TRPA1) Mediates Hydrogen Sulfide-induced Ca²⁺ Entry and Nitric Oxide Production in Human Cerebrovascular Endothelium. [PDF]

Curr Neuropharmacol
Introduction The gasotransmitter hydrogen sulfide (H2S) modulates various brain functions, including neuron excitability, synaptic plasticity, and Ca2+ dynamics.
Soda T, Brunetti V, De Sarro G, Biella G, Moccia F, Berra-Romani R, Scarpellino G.   +6 more
europepmc   +2 more sources

Nociceptive transient receptor potential ankyrin 1 (TRPA1) in sensory neurons are targets of the antifungal drug econazole. [PDF]

BMC Pharmacol Toxicol
Econazole is a widely used imidazole derivative antifungal for treating skin infections. The molecular targets for its frequent adverse effects of skin irritation symptoms, such as pruritus, burning sensation, and pain, have not been clarified. Transient
Kasuya K, Takahashi K, Hashimoto M, Ohta T.   +3 more
europepmc   +2 more sources

Formaldehyde and the transient receptor potential ankyrin-1 contribute to electronic cigarette aerosol-induced endothelial dysfunction in mice. [PDF]

Toxicol Sci
Electronic Nicotine Delivery Systems (ENDS) aerosol exposures can induce endothelial dysfunction (ED) in healthy young humans and animals. Thermal degradation of ENDS solvents, propylene glycol and vegetable glycerin (PG: VG), generates abundant ...
Jin L, Richardson A, Lynch J, Lorkiewicz P, Srivastava S, Fryar L, Miller A, Theis W, Shirk G, Bhatnagar A, Srivastava S, Riggs DW, Conklin DJ.   +12 more
europepmc   +2 more sources

The effect of allyl isothiocyanate on chondrocyte phenotype is matrix stiffness-dependent: Possible involvement of TRPA1 activation

Frontiers in Molecular Biosciences, 2023
Osteoarthritis (OA) is a chronic joint disease with increasing prevalence. Chondrocytes (CHs) are highly differentiated end-stage cells with a secretory phenotype that keeps the extracellular matrix (ECM) balanced and the cartilage environment stable ...
Hui Che, Zhiqiang Shao, Jiangchen Ding, Hua Gao, Xiangyu Liu, Hailong Chen, Shuangyu Cai, Jiaying Ge, Chengqiang Wang, Jun Wu, Yuefeng Hao   +10 more
doaj   +1 more source

Transient Receptor Potential Ankyrin 1 (TRPA1) Methylation and Chronic Pain: A Systematic Review. [PDF]

Genes (Basel), 2023
Background and Objective: Chronic pain represents a major global health issue in terms of psycho-physiological, therapeutic, and economic burden, not limited to adults but also to the pediatric age. Despite its great impact, its molecular mechanisms have
Celsi F, Peri F, Cavasin J, Zupin L, Cozzi G, Barbi E, Crovella S.   +6 more
europepmc   +2 more sources

Zhenxin Anshen formula ameliorates atopic der-matitis-like skin dysfunction in mice and regulation of transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 in Neural pathways. [PDF]

J Tradit Chin Med, 2023
Yiding Z, Xiaoning Y, Shanshan J, Yong L, Chun D, Huiyan C, Chaoyi M.   +6 more
europepmc   +2 more sources

Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. [PDF]

PLoS ONE, 2011
Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic ...
Andreas Binder, Denisa May, Ralf Baron, Christoph Maier, Thomas R Tölle, Rolf-Detlef Treede, Achim Berthele, Frank Faltraco, Herta Flor, Janne Gierthmühlen, Sierk Haenisch, Volker Huge, Walter Magerl, Christian Maihöfner, Helmut Richter, Roman Rolke, Andrea Scherens, Nurcan Uçeyler, Mike Ufer, Gunnar Wasner, Jihong Zhu, Ingolf Cascorbi   +21 more
doaj   +1 more source

Functional Transient Receptor Potential Ankyrin 1 and Vanilloid 1 Ion Channels Are Overexpressed in Human Oral Squamous Cell Carcinoma. [PDF]

Int J Mol Sci, 2022
Oral squamous cell carcinoma (OSCC) is a common cancer with poor prognosis. Transient Receptor Potential Ankyrin 1 (TRPA1) and Vanilloid 1 (TRPV1) receptors are non-selective cation channels expressed on primary sensory neurons and epithelial and immune ...
Kiss F, Kormos V, Szőke É, Kecskés A, Tóth N, Steib A, Szállási Á, Scheich B, Gaszner B, Kun J, Fülöp G, Pohóczky K, Helyes Z.   +12 more
europepmc   +2 more sources