Results 71 to 80 of about 37,224,805 (160)

Activation of transient receptor potential ankyrin 1 induces CGRP release from spinal cord synaptosomes

, 2015
Transient receptor potential ankyrin 1 (TRPA1) is a sensor of nociceptive stimuli, expressed predominantly in a subpopulation of peptidergic sensory neurons which co-express the noxious heat-sensor transient receptor potential vanilloid 1. In this study,
Bevan, Stuart; id_orcid, Gentry, Clive; id_orcid, Broad, Lisa M., Quallo, Talisia, Mogg, Adrian J.   +4 more
core   +1 more source

Activation of Transient Receptor Potential Ankyrin-1 by Insoluble Particulate Material and Association with Asthma [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2015
Abstract Inhaled irritants activate transient receptor potential ankyrin-1 (TRPA1), resulting in cough, bronchoconstriction, and inflammation/edema. TRPA1 is also implicated in the pathogenesis of asthma. Our hypothesis was that particulate materials activate TRPA1 via a mechanism distinct from chemical agonists and that, in a cohort ...
Cassandra E, Deering-Rice, Darien, Shapiro, Erin G, Romero, Chris, Stockmann, Tatjana S, Bevans, Quang M, Phan, Bryan L, Stone, Bernhard, Fassl, Flory, Nkoy, Derek A, Uchida, Robert M, Ward, John M, Veranth, Christopher A, Reilly   +12 more
openaire   +2 more sources

MAMMALIAN TRANSIENT RECEPTOR POTENTIAL TRPA1 CHANNELS: FROM STRUCTURE TO DISEASE

, 2019
The transient receptor potential ankyrin (TRPA) channels are Ca2+-permeable nonselective cation channels remarkably conserved through the animal kingdom.
Boonen, Brett, Brett Boonen, Yeranddy A. Alpizar, Startek, Justyna B., Alvarez-Collazo, Julio, Alpizar, Yeranddy A., Julio Alvarez-Collazo, Talavera, Karel, Bernd Nilius, Naert, Robbe, Alicia Sanchez, Karel Talavera, Nilius, Bernd, AGUIAR ALPIZAR, Yeranddy, Robbe Naert, Alpizar, Yeranddy A, Justyna B. Startek, Startek, Justyna B, Sanchez, Alicia   +18 more
core   +1 more source

Roles of Transient Receptor Potential Ankyrin 1 in Oxaliplatin-Induced Peripheral Neuropathy

Biological & Pharmaceutical Bulletin, 2017
Chemotherapy-induced peripheral neuropathy (CIPN), characterized by symptoms of paresthesia, dysesthesia, numbness, and pain, is a common adverse effect of several chemotherapeutic agents, including platinum-based agents, taxanes, and vinca alkaloids.
Nakagawa, Takayuki, Kaneko, Shuji
openaire   +3 more sources

Chemo-nociceptive signalling from the colon is enhanced by mild colitis and blocked by inhibition of transient receptor potential ankyrin 1 channels

, 2010
Transient receptor potential ankyrin 1 (TRPA1) channels are expressed by primary afferent neurones and activated by irritant chemicals including allyl isothiocyanate (AITC).
Holzer, Peter, Mitrovic, Martina, Bock, Elisabeth, Pabst, Maria A, Shahbazian, Anaid   +4 more
core   +1 more source

Transient Receptor Potential Ankyrin 1 (TRPA1) Channel and Neurogenic Inflammation in Pathogenesis of Asthma [PDF]

Medical Science Monitor, 2016
Asthma is characterized by airway inflammation, airway obstruction, and airway hyperresponsiveness (AHR), and it affects 300 million people worldwide. However, our current understanding of the molecular mechanisms that underlie asthma remains limited.
Yang, Hang, Li, ShuZhuang
openaire   +2 more sources

Transient receptor potential ankyrin 1 promotes recovery of colonic motility following pelvic nerve injury in mice

Di-san junyi daxue xuebao, 2019
Objective To investigate the role of transient receptor potential ankyrin 1 (TRPA1) in the recovery of colonic motility following pelvic nerve denervation (PND) in mice. Methods A total of 108 male C57 mice were randomized into PND model group (n=54) and
ZHANG Yong, TIAN Yue, ZHENG Huichao, DAI Feixiang, SHI Huiwen   +4 more
doaj   +1 more source

Considerations about Study on Mechanisms of Thermal Efficacies of Moxibustion from Activities of Transient Receptor Potential Family

针刺研究, 2012
Of the mammalian transient receptor potential(TRP) superfamily members,transient receptor potential vanilloid 1(TRPV 1),TRPV 2,TRPV 3,TRPV 4,melastatin transient receptor potential(TRPM) 4,TRPM 5,and TRP ankyrin 1(TRPA 1),are mostly permeable to both ...
LU Sheng-feng1, 2, YIN Hai-yan2, TANG Yong2, ZHANG Cheng-shun2, YU Mei-ling3, LUO Ling2   +6 more
doaj   +2 more sources

Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction

Journal of Inflammation, 2018
Background Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger.
Songjiang Yin, Li Zhang, Liang Ding, Zhengquan Huang, Bo Xu, XiaoChen Li, Peimin Wang, Jun Mao   +7 more
doaj   +1 more source

The TRPA1 Channel in the Cardiovascular System: Promising Features and Challenges

Frontiers in Pharmacology, 2019
The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable nonselective cation channel in the plasma membrane that belongs to the transient receptor potential (TRP) channel superfamily.
Zhen Wang, Zhen Wang, Zhen Wang, Di Ye, Di Ye, Di Ye, Jing Ye, Jing Ye, Jing Ye, Menglong Wang, Menglong Wang, Menglong Wang, Jianfang Liu, Jianfang Liu, Jianfang Liu, Huimin Jiang, Huimin Jiang, Huimin Jiang, Yao Xu, Yao Xu, Yao Xu, Jishou Zhang, Jiangbin Chen, Jun Wan, Jun Wan, Jun Wan   +25 more
doaj   +1 more source