Results 81 to 90 of about 111,852,927 (168)

TRPA1 and TRPM8 in Allergic Rhinitis and Chronic Rhinosinusitis: Emerging Role in Neuroimmune Inflammation

Biomedicines
Nasal hyperreactivity (NHR) is a core symptom of allergic rhinitis (AR) and chronic rhinosinusitis (CRS), frequently induced by cold stimuli. Accumulating evidence indicates that NHR is largely mediated by neuroimmune mechanisms rather than classical ...
Tianhui Kang, Zijun Qiu, Surita Aodeng, Yuzhuo Liu, Zhenzhen Zhu, Wei Lv   +5 more
doaj   +1 more source

Formaldehyde Induces Mesenteric Artery Relaxation via a Sensitive Transient Receptor Potential Ankyrin-1 (TRPA1) and Endothelium-Dependent Mechanism: Potential Role in Postprandial Hyperemia

Frontiers in Physiology, 2019
Formaldehyde (FA), the smallest aldehyde, is generated endogenously, and is widespread in the environment in foods, beverages and as a gas phase product of incomplete combustion.
L. Jin, L. Jin, G. Jagatheesan, G. Jagatheesan, G. Jagatheesan, G. Jagatheesan, L. Guo, L. Guo, L. Guo, L. Guo, M. Nystoriak, M. Nystoriak, M. Nystoriak, M. Nystoriak, M. Malovichko, M. Malovichko, M. Malovichko, P. Lorkiewicz, P. Lorkiewicz, P. Lorkiewicz, P. Lorkiewicz, A. Bhatnagar, A. Bhatnagar, A. Bhatnagar, A. Bhatnagar, A. Bhatnagar, S. Srivastava, S. Srivastava, S. Srivastava, S. Srivastava, D. J. Conklin, D. J. Conklin, D. J. Conklin, D. J. Conklin, D. J. Conklin   +34 more
doaj   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

MAMMALIAN TRANSIENT RECEPTOR POTENTIAL TRPA1 CHANNELS: FROM STRUCTURE TO DISEASE [PDF]

, 2019
The transient receptor potential ankyrin (TRPA) channels are Ca2+-permeable nonselective cation channels remarkably conserved through the animal kingdom.
Boonen, Brett, Brett Boonen, Yeranddy A. Alpizar, Startek, Justyna B., Alvarez-Collazo, Julio, Alpizar, Yeranddy A., Julio Alvarez-Collazo, Talavera, Karel, Bernd Nilius, Naert, Robbe, Alicia Sanchez, Karel Talavera, Nilius, Bernd, AGUIAR ALPIZAR, Yeranddy, Robbe Naert, Alpizar, Yeranddy A, Justyna B. Startek, Startek, Justyna B, Sanchez, Alicia   +18 more
core   +1 more source

Human and Mouse TRPA1 Are Heat and Cold Sensors Differentially Tuned by Voltage

Cells, 2019
Transient receptor potential ankyrin 1 channel (TRPA1) serves as a key sensor for reactive electrophilic compounds across all species. Its sensitivity to temperature, however, differs among species, a variability that has been attributed to an ...
Viktor Sinica, Lucie Zimova, Kristyna Barvikova, Lucie Macikova, Ivan Barvik, Viktorie Vlachova   +5 more
doaj   +1 more source

Effects of Pistacia lentiscus Leaf‐Twig and Resin (Mastic) Oils on Salivary Flow in Healthy Individuals

Oral Diseases, EarlyView.
ABSTRACT Objective Pistacia lentiscus L. tree is known for its aromatic mastic gum containing terpenes α‐pinene and β‐myrcene, and has been applied as a traditional remedy in oral care for centuries. Previously, intranasal exposure to mastic resin volatiles increased salivary flow in healthy and dry‐mouth individuals. This study assessed the biological
Wiktoria Potocka, Luca van Eijndthoven, Marja L. Laine, Floris J. Bikker, Zainab Assy   +4 more
wiley   +1 more source

Genetic polymorphisms of TRPA1 does affect risk of cisplatin induced nephrotoxicity in Chinese population

Translational Oncology
Introduction: Irreversible acute kidney injury (AKI) caused by cisplatin limits its clinical use, and transient receptor potential anchor protein 1 (TRPA1) regulates cisplatin-induced nephrotoxicity (CIN) through NF-κB signaling pathway-mediated ...
Cong Wang, Guifei Deng, Siyu Niu, Xianglong Meng   +3 more
doaj   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Norterpene Cyclic Peroxides from the Marine Sponge Diacarnus spinipoculum, Inhibitors of Transient Receptor Potential Ankyrin 1

Bioassay-guided isolation of the extract from the marine sponge Diacarnus spinipoculum showing inhibitory activity against human transient receptor potential ankyrin 1 (hTRPA1) resulted in the isolation of 12 norditerpene cyclic peroxides (1–12) and ...
Yeon-Ju Lee (1476295), Kwiwan Jeong (17617401), Yeonwoo Cho (17914142), Jung Mi Hyun (17617398), Myung Jin Song (8780570), Chinmayee Bawkar (17914145)   +5 more
core   +2 more sources

Coptisine ameliorates colitis in mice by modulating cPLA2/TRPM8/CGRP-1 signaling pathways and strengthening intestinal barrier function [PDF]

Brazilian Journal of Medical and Biological Research
Coptisine (COP), a naturally occurring alkaloid, is recognized for its varied pharmacological impacts and its supportive function in intestinal well-being.
Wenbin Wu, Changcheng Shu, Lisheng Chen, Shizhang Wei, Manyi Jing, Hui Li, Haotian Li, Yanling Zhao   +7 more
doaj   +1 more source