Results 81 to 90 of about 37,224,805 (160)

Formaldehyde Induces Mesenteric Artery Relaxation via a Sensitive Transient Receptor Potential Ankyrin-1 (TRPA1) and Endothelium-Dependent Mechanism: Potential Role in Postprandial Hyperemia

Frontiers in Physiology, 2019
Formaldehyde (FA), the smallest aldehyde, is generated endogenously, and is widespread in the environment in foods, beverages and as a gas phase product of incomplete combustion.
L. Jin, L. Jin, G. Jagatheesan, G. Jagatheesan, G. Jagatheesan, G. Jagatheesan, L. Guo, L. Guo, L. Guo, L. Guo, M. Nystoriak, M. Nystoriak, M. Nystoriak, M. Nystoriak, M. Malovichko, M. Malovichko, M. Malovichko, P. Lorkiewicz, P. Lorkiewicz, P. Lorkiewicz, P. Lorkiewicz, A. Bhatnagar, A. Bhatnagar, A. Bhatnagar, A. Bhatnagar, A. Bhatnagar, S. Srivastava, S. Srivastava, S. Srivastava, S. Srivastava, D. J. Conklin, D. J. Conklin, D. J. Conklin, D. J. Conklin, D. J. Conklin   +34 more
doaj   +1 more source

Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception

, 2018
Cyclin-dependent kinase 5 (Cdk5) is a key neuronal kinase that is upregulated during inflammation, and can subsequently modulate sensitivity to nociceptive stimuli.
Stephen J. Raithel, John Joseph, Man-Kyo Chung, Paul Minetos, Ashok B. Kulkarni, Michael J. Iadarola, Matthew R. Sapio, B. K. Binukumar, Michaela Prochazkova, Niranjana D. Amin, Natalya Kurochkina, Harish C. Pant, Anita Terse, Andrew J. Mannes, Bradford E. Hall   +14 more
core   +1 more source

Human and Mouse TRPA1 Are Heat and Cold Sensors Differentially Tuned by Voltage

Cells, 2019
Transient receptor potential ankyrin 1 channel (TRPA1) serves as a key sensor for reactive electrophilic compounds across all species. Its sensitivity to temperature, however, differs among species, a variability that has been attributed to an ...
Viktor Sinica, Lucie Zimova, Kristyna Barvikova, Lucie Macikova, Ivan Barvik, Viktorie Vlachova   +5 more
doaj   +1 more source

Transient Receptor Potential Channel Polymorphisms Are Associated with the Somatosensory Function in Neuropathic Pain Patients [PDF]

, 2012
Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic ...
Cascorbi, Ingolf, Zhu, Jihong, Scherens, Andrea, Ufer, Mike, Gierthmühlen, Janne, Magerl, Walter, Berthele, Achim, Tölle, Thomas R., Maier, Christoph, Wasner, Gunnar, Rolke, Roman, Maihöfner, Christian, Baron, Ralf, Flor, Herta, Üçeyler, Nurcan, Huge, Volker, Richter, Helmut, Binder, Andreas, Treede, Rolf-Detlef, May, Denisa, Faltraco, Frank, Haenisch, Sierk   +21 more
core  

TRPA1 and TRPM8 in Allergic Rhinitis and Chronic Rhinosinusitis: Emerging Role in Neuroimmune Inflammation

Biomedicines
Nasal hyperreactivity (NHR) is a core symptom of allergic rhinitis (AR) and chronic rhinosinusitis (CRS), frequently induced by cold stimuli. Accumulating evidence indicates that NHR is largely mediated by neuroimmune mechanisms rather than classical ...
Tianhui Kang, Zijun Qiu, Surita Aodeng, Yuzhuo Liu, Zhenzhen Zhu, Wei Lv   +5 more
doaj   +1 more source

Coptisine ameliorates colitis in mice by modulating cPLA2/TRPM8/CGRP-1 signaling pathways and strengthening intestinal barrier function [PDF]

Brazilian Journal of Medical and Biological Research
Coptisine (COP), a naturally occurring alkaloid, is recognized for its varied pharmacological impacts and its supportive function in intestinal well-being.
Wenbin Wu, Changcheng Shu, Lisheng Chen, Shizhang Wei, Manyi Jing, Hui Li, Haotian Li, Yanling Zhao   +7 more
doaj   +1 more source

Genetic polymorphisms of TRPA1 does affect risk of cisplatin induced nephrotoxicity in Chinese population

Translational Oncology
Introduction: Irreversible acute kidney injury (AKI) caused by cisplatin limits its clinical use, and transient receptor potential anchor protein 1 (TRPA1) regulates cisplatin-induced nephrotoxicity (CIN) through NF-κB signaling pathway-mediated ...
Cong Wang, Guifei Deng, Siyu Niu, Xianglong Meng   +3 more
doaj   +1 more source

Role of the transient receptor potential vanilloid 1 in inflammation and sepsis

, 2011
Isabel Devesa1, Rosa Planells-Cases2, Gregorio Fernández-Ballester1, José Manuel González-Ros1, Antonio Ferrer-Montiel1, Asia Fernández-Carvajal11Instituto de Biología Molecular y Celular ...
Fernández-Carvajal AM, Devesa I, Ferrer-Montiel AV, González-Ros JM, Planells-Cases R, Fernández-Ballester GJ   +5 more
core  

Transient receptor potential ankyrin 1 (TRPA1) positively regulates imiquimod‐induced, psoriasiform dermal inflammation in mice [PDF]

, 2019
Transient receptor potential ankyrin 1 (TRPA1), a membrane protein ion channel, is known to mediate itch and pain in skin. The function of TRPA1, however, in psoriasiform dermatitis (PsD) is uncertain.
Zhenrui Shi, Zhou, Yan, Yu, Sebastian, Bo Wang, Carstens, Earl, Hwang, Samuel T, Yan Zhou, Dan T. Domocos, Han, Dan, Wu, Xuesong, Follansbee, Taylor, Dan Han, Domocos, Dan T, Mirela Carstens, Xuesong Wu, Shi, Zhenrui, Wang, Bo, Taylor Follansbee, Sebastian Yu, Samuel T. Hwang, Carstens, Mirela, Earl Carstens   +21 more
core   +1 more source

Identification and characterization of cell adhesion molecules controlling synapse stability [PDF]

, 2012
Neuronal circuits form the basis of a functional nervous system to process and integrate information and to react to environmental cues. The formation of functional synaptic connections between neurons is essential for the establishment of these circuits.
Enneking, Eva-Maria
core   +1 more source