Results 101 to 110 of about 28,002 (191)

Cyclodextrin derivatives decrease Transient Receptor Potential vanilloid 1 and Ankyrin 1 ion channel activation via altering the surrounding membrane microenvironment by cholesterol depletion

Frontiers in Cell and Developmental Biology
Transient Receptor Potential Vanilloid 1 (TRPV1) and Ankyrin 1 (TRPA1) are nonselective cation channels expressed in primary sensory neurons and several other non-neuronal structures such as immune cells, keratinocytes, and vascular smooth muscle cells ...
A. Nehr-Majoros, J. Erostyák, E. Fenyvesi, E. Szabó-Meleg, Levente Szőcs, György Sétáló, Zsuzsanna Helyes, Éva Szőke   +7 more
semanticscholar   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Transient receptor potential ankyrin 1 promotes recovery of colonic motility following pelvic nerve injury in mice

Di-san junyi daxue xuebao, 2019
Objective To investigate the role of transient receptor potential ankyrin 1 (TRPA1) in the recovery of colonic motility following pelvic nerve denervation (PND) in mice. Methods A total of 108 male C57 mice were randomized into PND model group (n=54) and
ZHANG Yong, TIAN Yue, ZHENG Huichao, DAI Feixiang, SHI Huiwen   +4 more
doaj   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Transient Receptor Potential Ankyrin 1 (TRPA1) Is Involved in Upregulating Interleukin-6 Expression in Osteoarthritic Chondrocyte Models

International Journal of Molecular Sciences, 2020
Transient receptor potential ankyrin 1 (TRPA1) is a membrane-bound ion channel found in neurons, where it mediates nociception and neurogenic inflammation.
E. Nummenmaa, M. Hämäläinen, Antti Pemmari, Lauri J. Moilanen, L. Tuure, R. Nieminen, T. Moilanen, K. Vuolteenaho, E. Moilanen   +8 more
semanticscholar   +1 more source

Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction

Journal of Inflammation, 2018
Background Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger.
Songjiang Yin, Li Zhang, Liang Ding, Zhengquan Huang, Bo Xu, XiaoChen Li, Peimin Wang, Jun Mao   +7 more
doaj   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

The TRPA1 Channel in the Cardiovascular System: Promising Features and Challenges

Frontiers in Pharmacology, 2019
The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable nonselective cation channel in the plasma membrane that belongs to the transient receptor potential (TRP) channel superfamily.
Zhen Wang, Zhen Wang, Zhen Wang, Di Ye, Di Ye, Di Ye, Jing Ye, Jing Ye, Jing Ye, Menglong Wang, Menglong Wang, Menglong Wang, Jianfang Liu, Jianfang Liu, Jianfang Liu, Huimin Jiang, Huimin Jiang, Huimin Jiang, Yao Xu, Yao Xu, Yao Xu, Jishou Zhang, Jiangbin Chen, Jun Wan, Jun Wan, Jun Wan   +25 more
doaj   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Formaldehyde Induces Mesenteric Artery Relaxation via a Sensitive Transient Receptor Potential Ankyrin-1 (TRPA1) and Endothelium-Dependent Mechanism: Potential Role in Postprandial Hyperemia

Frontiers in Physiology, 2019
Formaldehyde (FA), the smallest aldehyde, is generated endogenously, and is widespread in the environment in foods, beverages and as a gas phase product of incomplete combustion.
L. Jin, L. Jin, G. Jagatheesan, G. Jagatheesan, G. Jagatheesan, G. Jagatheesan, L. Guo, L. Guo, L. Guo, L. Guo, M. Nystoriak, M. Nystoriak, M. Nystoriak, M. Nystoriak, M. Malovichko, M. Malovichko, M. Malovichko, P. Lorkiewicz, P. Lorkiewicz, P. Lorkiewicz, P. Lorkiewicz, A. Bhatnagar, A. Bhatnagar, A. Bhatnagar, A. Bhatnagar, A. Bhatnagar, S. Srivastava, S. Srivastava, S. Srivastava, S. Srivastava, D. J. Conklin, D. J. Conklin, D. J. Conklin, D. J. Conklin, D. J. Conklin   +34 more
doaj   +1 more source