Results 91 to 100 of about 28,002 (191)

Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception

American Journal of Physiology-Cell Physiology, 2011
Transient receptor potential (TRP) ankyrin 1 (TRPA1) is a Ca2+-permeant, nonselective cationic channel. It is predominantly expressed in the C afferent sensory nerve fibers of trigeminal and dorsal root ganglion neurons and is highly coexpressed with the nociceptive ion channel transient receptor potential vanilloid 1 (TRPV1).
Manish, Raisinghani, Linlin, Zhong, Joseph A, Jeffry, Mahendra, Bishnoi, Reddy M, Pabbidi, Fátima, Pimentel, De-Shou, Cao, M Steven, Evans, Louis S, Premkumar   +8 more
openaire   +3 more sources

Can trigeminal sensations impact saltiness perception? A mini‐review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Many food companies have begun to reduce the salt content in their products due to health concerns; however, this reduction in salt content can affect the food's sensory appeal and flavour complexity. Flavour is defined as a combination of odour (i.e., smell), taste (i.e., gustation) and trigeminal sensations (i.e., chemesthesis).
Emily Dolan, Nicoletta Faraone, Matthew B McSweeney   +2 more
wiley   +1 more source

Roles of Transient Receptor Potential Ankyrin 1 in Oxaliplatin-Induced Peripheral Neuropathy

Biological & Pharmaceutical Bulletin, 2017
Chemotherapy-induced peripheral neuropathy (CIPN), characterized by symptoms of paresthesia, dysesthesia, numbness, and pain, is a common adverse effect of several chemotherapeutic agents, including platinum-based agents, taxanes, and vinca alkaloids.
Nakagawa, Takayuki, Kaneko, Shuji
openaire   +3 more sources

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

Activation of Transient Receptor Potential Ankyrin-1 by Insoluble Particulate Material and Association with Asthma [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2015
Abstract Inhaled irritants activate transient receptor potential ankyrin-1 (TRPA1), resulting in cough, bronchoconstriction, and inflammation/edema. TRPA1 is also implicated in the pathogenesis of asthma. Our hypothesis was that particulate materials activate TRPA1 via a mechanism distinct from chemical agonists and that, in a cohort ...
Cassandra E, Deering-Rice, Darien, Shapiro, Erin G, Romero, Chris, Stockmann, Tatjana S, Bevans, Quang M, Phan, Bryan L, Stone, Bernhard, Fassl, Flory, Nkoy, Derek A, Uchida, Robert M, Ward, John M, Veranth, Christopher A, Reilly   +12 more
openaire   +2 more sources

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2013
Chronic pancreatitis (CP) is a devastating disease characterized by persistent and uncontrolled abdominal pain. Our lack of understanding is partially due to the lack of experimental models that mimic the human disease and also to the lack of validated behavioral measures of visceral pain.
Fiore, Cattaruzza, Cali, Johnson, Alan, Leggit, Eileen, Grady, A Katrin, Schenk, Ferda, Cevikbas, Wendy, Cedron, Sandhya, Bondada, Rebekah, Kirkwood, Brian, Malone, Martin, Steinhoff, Nigel, Bunnett, Kimberly S, Kirkwood   +12 more
openaire   +3 more sources

Characterization of a Ligand Binding Site in the Human Transient Receptor Potential Ankyrin 1 Pore [PDF]

Biophysical Journal, 2013
The pharmacology and regulation of Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel activity is intricate due to the physiological function as an integrator of multiple chemical, mechanical, and temperature stimuli as well as differences in species pharmacology.
Klement, Göran, Eisele, Lina, Malinowsky, David, Nolting, Andreas, Svensson, Mats, Terp, Gitte, Weigelt, Dirk, Dabrowski, Michael   +7 more
openaire   +2 more sources

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source