Results 91 to 100 of about 37,224,805 (160)

Role of PAR2 in regulating oxaliplatin-induced neuropathic pain via TRPA1

Translational Neuroscience, 2015
Oxaliplatin (OXL) is a third-generation chemotherapeutic agent commonly used to treat metastatic digestive tumors; however, one of the main limiting complications of OXL is neuropathic pain.
Tian Liujun, Fan Tianren, Zhou Nan, Guo Hui, Zhang Weijie   +4 more
doaj   +1 more source

Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes [PDF]

, 2009
We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Anthony P. Albert, Saleh, Sohag N., Albert, Anthony P., Sohag N. Saleh, William A. Large, Large, William A., Large, WA, Saleh, SN, Albert, AP   +8 more
core   +1 more source

유지놀에 의한 Transient Receptor Potential Ankyrin 1의 활성화 [PDF]

, 2015
학위논문 (석사)-- 서울대학교 대학원 : 치의과학과, 2015. 2. 오석배.The structural similarity of eugenol to cinnamaldehyde, an active ligand for transient receptor potential ankyrin 1 (TRPA1), suggests that eugenol might produce its effect via TRPA1 in addition to TRPV1 as we ...
임상택
core  

Protective Effect of Transient Receptor Potential Ankyrin 1 Inhibition on Renal Ischemia Reperfusion Injury in Rats

The transient receptor potential ankyrin 1 (TRPA1) channels, characterized as nonselective cation channels with permeability to calcium ions (Ca2 +), are part of the extensive family of transient receptor potential (TRP) channels.
Cakir, Murat, Sekerci, Guldeniz, Oz, Samet, Bircan, Burak, Aydin, Ali, Firat, Semanur   +5 more
core   +1 more source

Altered excitation-contraction coupling in human chronic atrial fibrillation [PDF]

, 2012
This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory ...
Grandi, E., Pandit, S.V., Workman, A.J.
core   +2 more sources

Analyses of Synthetic N‑Acyl Dopamine Derivatives Revealing Different Structural Requirements for Their Anti-inflammatory and Transient-Receptor-Potential-Channel-of-the-Vanilloid-Receptor-Subfamily-Subtype‑1 (TRPV1)-Activating Properties

, 2018
We studied the chemical entities within N-octanoyl dopamine (NOD) responsible for the activation of transient-receptor-potential channels of the vanilloid-receptor subtype 1 (TRPV1) and inhibition of inflammation.
Bastian Theisinger (310806), Björn B. Hofmann (5044262), Ralf Loesel (452852), Wolfgang Greffrath (310805), Björn Wängler (1801330), Eleni Stamellou (452849), Martin C. Harmsen (4389586), Handan Moerz (5044259), Marc Pretze (3131406), Julio Caballero (531146), Bernhard K. Krämer (5044253), Yingchun Li (636496), Rolf-Detlef Treede (226189), Anna-Isabelle Kälsch (5044256), Carmen Wängler (1790250), Mathias Hafner (144687), Benito A. Yard (310816), Sarah Klotz (290590), Uta Binzen (310804), Steffen Roth (496337), Prama Pallavi (577866)   +20 more
core   +1 more source

Discovery of BAY-390, a Selective CNS Penetrant Chemical Probe as Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonist

Transient receptor potential ankyrin 1 (TRPA1) is a voltage-dependent, ligand-gated ion channel, and activation thereof is linked to a variety of painful conditions.
Daniel Basting (2688901), Stephen Hess (14352365), Christopher Pearson (1418974), Andrea Rotgeri (14352371), Alexis Laux-Biehlmann (8115638), Philip Elves (14352362), Schanila Nawaz (307018), Andreas Steinmeyer (261726), Stefan Bäurle (6391307), Thomas M. Zollner (6391328), Stuart Flanagan (14209873), James Jenkins (2532082), Stefanie Mesch (2316391), Ulrich Bothe (6391322), Daryl Walter (6391325), Anne-Marie Coelho (14352368), Hideki Miyatake Ondozabal (14352359)   +16 more
core   +2 more sources

Norterpene Cyclic Peroxides from the Marine Sponge Diacarnus spinipoculum, Inhibitors of Transient Receptor Potential Ankyrin 1

Bioassay-guided isolation of the extract from the marine sponge Diacarnus spinipoculum showing inhibitory activity against human transient receptor potential ankyrin 1 (hTRPA1) resulted in the isolation of 12 norditerpene cyclic peroxides (1–12) and ...
Yeon-Ju Lee (1476295), Kwiwan Jeong (17617401), Yeonwoo Cho (17914142), Jung Mi Hyun (17617398), Myung Jin Song (8780570), Chinmayee Bawkar (17914145)   +5 more
core   +2 more sources

Canine, mouse, and human transient receptor potential ankyrin 1 (TRPA1) channels show different sensitivity to menthol or cold stimulation. [PDF]

J Vet Med Sci, 2023
Yamaguchi T, Uchida K, Yamazaki J.
europepmc   +1 more source

Pharmacologic Activation of TRPA1 Induces Multi-Target Anticancer Responses via Apoptotic and Mitochondrial Pathways

Pharmaceuticals
Objectives: Transient Receptor Potential Ankyrin 1 (TRPA1) has emerged as a stress-responsive ion channel involved in calcium homeostasis, redox signaling, migration, and cancer cell survival; however, the therapeutic relevance of TRPA1 activation versus
Murat Çakır, Ali Aydın, Burçin Türkmenoğlu, Mücahit Seçme   +3 more
doaj   +1 more source