Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain. [PDF]
Adv Sci (Weinh)Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Pan Y +10 more
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TGF-β1 Directly Sensitizes Capsaicin-Sensitive Lung Vagal Neurons to Promote Airway Hypersensitivity. [PDF]
Acta Physiol (Oxf)ABSTRACT Aim Transforming growth factor‐β1 (TGF‐β1) is a pleiotropic cytokine implicated in the pathogenesis of inflammatory airway diseases such as asthma. Airway hypersensitivity (AHS), arising from sensitization of capsaicin‐sensitive lung vagal (CSLV) afferents, is a hallmark of these airway diseases.
Chen YY, Chan NJ, Hsu CC.
europepmc +2 more sources
TRPA1 as a O2 sensor detects microenvironmental hypoxia in the mice anterior cingulate cortex
Scientific Reports, 2023 Transient receptor potential ankyrin 1 (TRPA1) is a member of the TRP channel family and is expressed in peripheral and central nervous systems. In the periphery, TRPA1 senses cold and pain. However, the functions of TRPA1 in the CNS are unclear.
Ryo Kawabata +5 more
doaj +1 more source
Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. [PDF]
PLoS ONE, 2012 BACKGROUND: The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism.
Romina Nassini +15 more
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Frontiers in Oncology, 2021 Melanoma skin cancer is extremely aggressive with increasing incidence and mortality. Among the emerging therapeutic targets in the treatment of cancer, the family of transient receptor potential channels (TRPs) has been reported as a possible ...
Maria Fernanda Forni +7 more
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Identification of a splice variant of mouse TRPA1 that regulates TRPA1 activity [PDF]
Nature Communications, 2013 Transient receptor potential ankyrin 1 (TRPA1) protein is a nonselective cation channel. Although many studies suggest that TRPA1 is involved in inflammatory and neuropathic pain, its mechanism remains unclear. Here we identify an alternative splice variant of the mouse Trpa1 gene.
Zhou, Yiming +3 more
openaire +2 more sources
Neuroprotective effects of TRPA1 channels in the cerebral endothelium following ischemic stroke
eLife, 2018 Hypoxia and ischemia are linked to oxidative stress, which can activate the oxidant-sensitive transient receptor potential ankyrin 1 (TRPA1) channel in cerebral artery endothelial cells, leading to vasodilation.
Paulo Wagner Pires, Scott Earley
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Application of PASS Algorithm for the Discovery of New Trpa1 Antagonists
Proceedings, 2019 TRPA1 is a calcium ion channel found on the plasma membrane of many animal cells and it is [...]
Trif Comin +4 more
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TRPA1 is functionally expressed primarily by IB4-binding, non-peptidergic mouse and rat sensory neurons. [PDF]
PLoS ONE, 2012 Subpopulations of somatosensory neurons are characterized by functional properties and expression of receptor proteins and surface markers. CGRP expression and IB4-binding are commonly used to define peptidergic and non-peptidergic subpopulations.
Marie E Barabas +2 more
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Applied Sciences, 2022 Because transient receptor potential ankyrin 1 (TRPA1) is involved in various physiological functions, TRPA1-targeting drugs have been energetically developed. Although TRPA1 is considered a multimodal receptor, the structural diversity of TRPA1 agonists
Yuko Terada +7 more
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