Results 11 to 20 of about 23,681 (244)
No functional TRPA1 in cardiomyocytes [PDF]
Acta Physiologica, 2021 AbstractAimThere is mounting evidence that TRPA1 has a role in cardiac physiology and pathophysiology. We aim to clarify the site of TRPA1 expression in the heart and in particular whether the channel is expressed in cardiomyocytes.MethodsDue to the high calcium conductance of TRPA1, and marginal calcium changes being detectable, microfluorimetry in ...
Clara Hoebart +9 more
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Ethyl Vanillin Activates TRPA1 [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2017 The nonselective cation channel transient receptor potential ankryn subtype family 1 (TRPA1) is expressed in neurons of dorsal root ganglia and trigeminal ganglia and also in vagal afferent neurons that innervate the lungs and gastrointestinal tract. Many TRPA1 agonists are reactive electrophilic compounds that form covalent adducts with TRPA1.
Shaw-Wen, Wu +4 more
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Journal of Neurophysiology, 2019 The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed in pain-sensing neurons and other tissues and has become a major target in the development of novel pharmaceuticals. A remarkable feature of the channel is its long list of activators, many of which we are exposed to in daily life.
Jannis E. Meents +2 more
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Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels [PDF]
Proceedings of the National Academy of Sciences, 2008 Caffeine has various well-characterized pharmacological effects, but in mammals there are no known plasma membrane receptors or ion channels activated by caffeine. We observed that caffeine activates mouse transient receptor potential A1 (TRPA1) in heterologous expression systems by Ca i 2+ imaging and ...
Katsuhiro, Nagatomo, Yoshihiro, Kubo
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TRPA1 is functionally expressed primarily by IB4-binding, non-peptidergic mouse and rat sensory neurons. [PDF]
PLoS ONE, 2012 Subpopulations of somatosensory neurons are characterized by functional properties and expression of receptor proteins and surface markers. CGRP expression and IB4-binding are commonly used to define peptidergic and non-peptidergic subpopulations.
Marie E Barabas +2 more
doaj +1 more source
Frontiers in Oncology, 2021 Melanoma skin cancer is extremely aggressive with increasing incidence and mortality. Among the emerging therapeutic targets in the treatment of cancer, the family of transient receptor potential channels (TRPs) has been reported as a possible ...
Maria Fernanda Forni +7 more
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Catechol estrogens stimulate insulin secretion in pancreatic β-cells via activation of the transient receptor potential A1 (TRPA1) channel [PDF]
, 2019 Estrogen hormones play an important role in controlling glucose homeostasis and pancreatic β-cell function. Despite the significance of estrogen hormones for regulation of glucose metabolism, little is known about the roles of endogenous estrogen ...
Cabrera, Over +7 more
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TRPA1 Antagonists for Pain Relief [PDF]
Pharmaceuticals, 2018 Here, we review the literature assessing the role of transient receptor potential ankyrin 1 (TRPA1), a calcium-permeable non-selective cation channel, in various types of pain conditions. In the nervous system, TRPA1 is expressed in a subpopulation of nociceptive primary sensory neurons, astroglia, oligodendrocytes and Schwann cells.
Ari Koivisto +3 more
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Emergence of functional sensory subtypes as defined by transient receptor potential channel expression [PDF]
, 2007 The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception of touch, temperature, and pain. A differential expression of transient receptor potential (TRP)
AlQatari, M +3 more
core +1 more source
Sumatriptan activates TRPA1 [PDF]
Cephalalgia Reports, 2019 Background: Migraine therapy with sumatriptan may cause adverse side effects like pain at the injection site, muscle pain, and transient aggravation of headaches. In animal experiments, sumatriptan excited or sensitized slowly conducting meningeal afferents. We hypothesized that sumatriptan may activate transduction channels of the “irritant receptor,”
Alexandru Babes +3 more
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