Results 21 to 30 of about 12,878 (216)
A TREK-1/AQP4/TRPA1/BDNF Signaling Axis Is Associated With Astrocytic Volume Transients, Synaptic Plasticity, and Spatial Memory. [PDF]
GliaAstrocytic TREK‐1‐dependent volume transients contribute to hippocampal synaptic plasticity and memory formation. TRPA1‐mediated astrocytic calcium signaling is required for long‐term potentiation, while astrocytic BDNF is necessary and sufficient to support sustained synaptic plasticity.
Drew VJ +6 more
europepmc +2 more sources
Dexmedetomidine protects against ischemia and reperfusion-induced kidney injury in rats by inhibiting the expression of TRPM2 and TRPA1 channels [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Renal ischemia and reperfusion (I/R) injury is a potentially serious issue encountered during various medical and surgical procedures. This condition is clinically significant because of its high incidence and mortality rate. In this study,
Abdulkadir Uzunboy +5 more
doaj +1 more source
TRPA1 Regulates Fibrosis-Associated Transcriptional Pathways in Human Lung Epithelial Cells. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Transient receptor potential ankyrin 1 (TRPA1) is a cation channel originally identified in lung fibroblasts and extensively studied in sensory neurons, where it is associated with pain and neurogenic inflammation. We and others have recently shown that TRPA1 is also expressed in lung epithelial cells and that its expression is regulated by ...
Halonen L +5 more
europepmc +2 more sources
Neural Regeneration Research, 2019 Transient receptor potential ankyrin 1 (TRPA1) is a key player in pain and neurogenic inflammation, and is localized in nociceptive primary sensory dorsal root ganglion (DRG) neurons.
Xiao-Lei Wang +7 more
doaj +1 more source
Molecular Pain, 2020 Transient receptor potential ankyrin 1 (TRPA1) is well documented as an important molecule in pain hypersensitivity following inflammation and nerve injury and in many other cellular biological processes. Here, we show that TRPA1 is expressed not only by
Seung Min Shin +7 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Transient receptor potential ankyrin 1 (TRPA1) channel is an ion channel whose gating is controlled by agonists, such as allyl isothiocyanate (AITC), and temperature.
Megumi Yoshida +4 more
doaj +1 more source
Scientific Reports, 2021 The transient receptor potential ankyrin type 1 (TRPA1) channel belongs to the TRP superfamily of ion channels. TRPA1 is a membrane protein with multiple functions able to respond to noxious stimuli, reactive oxygen species, inflammatory cytokines or ...
Florentina Cojocaru +9 more
doaj +1 more source
Pharmaceuticals, 2021 Oligodendrocytes produce myelin, which provides insulation to axons and speeds up neuronal transmission. In ischaemic conditions, myelin is damaged, resulting in mental and physical disabilities.
Wendy Lajoso +7 more
doaj +1 more source
TRPA1 Antagonists for Pain Relief [PDF]
Pharmaceuticals, 2018 Here, we review the literature assessing the role of transient receptor potential ankyrin 1 (TRPA1), a calcium-permeable non-selective cation channel, in various types of pain conditions. In the nervous system, TRPA1 is expressed in a subpopulation of nociceptive primary sensory neurons, astroglia, oligodendrocytes and Schwann cells.
Ari Koivisto +3 more
openaire +4 more sources
ROS/TRPA1/CGRP signaling mediates cortical spreading depression
The Journal of Headache and Pain, 2019 Objectives The transient receptor potential ankyrin A 1 (TRPA1) channel and calcitonin gene-related peptide (CGRP) are targets for migraine prophylaxis.
Liwen Jiang +3 more
doaj +1 more source