Results 21 to 30 of about 13,150 (209)

TRPA1 Antagonists for Pain Relief [PDF]

Pharmaceuticals, 2018
Here, we review the literature assessing the role of transient receptor potential ankyrin 1 (TRPA1), a calcium-permeable non-selective cation channel, in various types of pain conditions. In the nervous system, TRPA1 is expressed in a subpopulation of nociceptive primary sensory neurons, astroglia, oligodendrocytes and Schwann cells.
Ari Koivisto, Niina Jalava, Raymond Bratty, Antti Pertovaara   +3 more
openaire   +4 more sources

Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists

Molecular Pain, 2007
Agonists of TRPA1 such as mustard oil and its key component AITC cause pain and neurogenic inflammation in humans and pain behavior in rodents. TRPA1 is activated by numerous reactive compounds making it a sensor for reactive compounds in the body ...
Immke David C, Wang Weiya, Gao BaoXi, Tamir Rami, Klionsky Lana, Nishimura Nobuko, Gavva Narender R   +6 more
doaj   +1 more source

Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells

Cells, 2014
Transient receptor potential (TRP) ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are implicated in modulation of cough and nociception. In vivo, TRPA1 and TRPV1 are often co-expressed in neurons and TRPA1V1 hetero-tetramer formation is noted in ...
Laura R. Sadofsky, Koti T. Sreekrishna, Yakang Lin, Renee Schinaman, Kate Gorka, Yogita Mantri, John Christian Haught, Thomas G. Huggins, Robert J. Isfort, Charles C. Bascom, Alyn H. Morice   +10 more
doaj   +1 more source

TMEM100, a regulator of TRPV1-TRPA1 interaction, contributes to temporomandibular disorder pain

Frontiers in Molecular Neuroscience, 2023
There is an unmet need to identify new therapeutic targets for temporomandibular disorder (TMD) pain because current treatments are limited and unsatisfactory.
Peng Wang, Qiaojuan Zhang, Fabiana C. Dias, Abbie Suttle, Xinzhong Dong, Yong Chen, Yong Chen, Yong Chen   +7 more
doaj   +1 more source

Transgenic Chlamydomonas Expressing Human Transient Receptor Potential Ankyrin 1 (TRPA1) Channels to Assess the Effect of Agonists and Antagonists

Frontiers in Pharmacology, 2020
Transient receptor potential ankyrin 1 (TRPA1) channel is an ion channel whose gating is controlled by agonists, such as allyl isothiocyanate (AITC), and temperature.
Megumi Yoshida, Ryodai Yamamiya, Yuto Shimizu, Kenjiro Yoshimura, Kenjiro Yoshimura   +4 more
doaj   +1 more source

Transient Receptor Potential Ankyrin-1 (TRPA1) Block Protects against Loss of White Matter Function during Ischaemia in the Mouse Optic Nerve

Pharmaceuticals, 2021
Oligodendrocytes produce myelin, which provides insulation to axons and speeds up neuronal transmission. In ischaemic conditions, myelin is damaged, resulting in mental and physical disabilities.
Wendy Lajoso, Grace Flower, Vincenzo Giacco, Anjuli Kaul, Circe La Mache, Andra Brăban, Angela Roxas, Nicola B. Hamilton   +7 more
doaj   +1 more source

Transient Receptor Potential Channel A1 (TRPA1) Regulates Sulfur Mustard-Induced Expression of Heat Shock 70 kDa Protein 6 (HSPA6) In Vitro

Cells, 2018
The chemosensory transient receptor potential ankyrin 1 (TRPA1) ion channel perceives different sensory stimuli. It also interacts with reactive exogenous compounds including the chemical warfare agent sulfur mustard (SM).
Robin Lüling, Harald John, Thomas Gudermann, Horst Thiermann, Harald Mückter, Tanja Popp, Dirk Steinritz   +6 more
doaj   +1 more source

Satellite glial cells in sensory ganglia express functional transient receptor potential ankyrin 1 that is sensitized in neuropathic and inflammatory pain

Molecular Pain, 2020
Transient receptor potential ankyrin 1 (TRPA1) is well documented as an important molecule in pain hypersensitivity following inflammation and nerve injury and in many other cellular biological processes. Here, we show that TRPA1 is expressed not only by
Seung Min Shin, Brandon Itson-Zoske, Yongsong Cai, Chensheng Qiu, Bin Pan, Cheryl L Stucky, Quinn H Hogan, Hongwei Yu   +7 more
doaj   +1 more source

Contribution of TRPV1-TRPA1 Interaction to the Single Channel Properties of the TRPA1 Channel [PDF]

Journal of Biological Chemistry, 2010
Several lines of evidence suggest that TRPA1 and TRPV1 mutually control the transduction of inflammation-induced noxious stimuli in sensory neurons. It was recently shown that certain TRPA1 properties are modulated by TRPV1. However, direct interaction between TRPA1 and TRPV1 as well as regulation of TRPA1 intrinsic characteristics by the TRPV1 channel
Alexander, Staruschenko, Nathaniel A, Jeske, Armen N, Akopian   +2 more
openaire   +2 more sources

TRPA1 is a polyunsaturated fatty acid sensor in mammals.

PLoS ONE, 2012
Fatty acids can act as important signaling molecules regulating diverse physiological processes. Our understanding, however, of fatty acid signaling mechanisms and receptor targets remains incomplete.
Arianne L Motter, Gerard P Ahern
doaj   +1 more source