Results 21 to 30 of about 12,428 (199)
Neuroprotective effects of TRPA1 channels in the cerebral endothelium following ischemic stroke
eLife, 2018 Hypoxia and ischemia are linked to oxidative stress, which can activate the oxidant-sensitive transient receptor potential ankyrin 1 (TRPA1) channel in cerebral artery endothelial cells, leading to vasodilation.
Paulo Wagner Pires, Scott Earley
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Contribution of TRPV1-TRPA1 Interaction to the Single Channel Properties of the TRPA1 Channel [PDF]
Journal of Biological Chemistry, 2010 Several lines of evidence suggest that TRPA1 and TRPV1 mutually control the transduction of inflammation-induced noxious stimuli in sensory neurons. It was recently shown that certain TRPA1 properties are modulated by TRPV1. However, direct interaction between TRPA1 and TRPV1 as well as regulation of TRPA1 intrinsic characteristics by the TRPV1 channel
Alexander, Staruschenko +2 more
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Application of PASS Algorithm for the Discovery of New Trpa1 Antagonists
Proceedings, 2019 TRPA1 is a calcium ion channel found on the plasma membrane of many animal cells and it is [...]
Trif Comin +4 more
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Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels [PDF]
Proceedings of the National Academy of Sciences, 2008 Caffeine has various well-characterized pharmacological effects, but in mammals there are no known plasma membrane receptors or ion channels activated by caffeine. We observed that caffeine activates mouse transient receptor potential A1 (TRPA1) in heterologous expression systems by Ca i 2+ imaging and ...
Katsuhiro, Nagatomo, Yoshihiro, Kubo
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Scientific Reports, 2021 The transient receptor potential ankyrin type 1 (TRPA1) channel belongs to the TRP superfamily of ion channels. TRPA1 is a membrane protein with multiple functions able to respond to noxious stimuli, reactive oxygen species, inflammatory cytokines or ...
Florentina Cojocaru +9 more
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Applied Sciences, 2022 Because transient receptor potential ankyrin 1 (TRPA1) is involved in various physiological functions, TRPA1-targeting drugs have been energetically developed. Although TRPA1 is considered a multimodal receptor, the structural diversity of TRPA1 agonists
Yuko Terada +7 more
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Neural Regeneration Research, 2019 Transient receptor potential ankyrin 1 (TRPA1) is a key player in pain and neurogenic inflammation, and is localized in nociceptive primary sensory dorsal root ganglion (DRG) neurons.
Xiao-Lei Wang +7 more
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Molecular Pain, 2020 Transient receptor potential ankyrin 1 (TRPA1) is well documented as an important molecule in pain hypersensitivity following inflammation and nerve injury and in many other cellular biological processes. Here, we show that TRPA1 is expressed not only by
Seung Min Shin +7 more
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Pharmaceuticals, 2021 Oligodendrocytes produce myelin, which provides insulation to axons and speeds up neuronal transmission. In ischaemic conditions, myelin is damaged, resulting in mental and physical disabilities.
Wendy Lajoso +7 more
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Ethyl Vanillin Activates TRPA1 [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2017 The nonselective cation channel transient receptor potential ankryn subtype family 1 (TRPA1) is expressed in neurons of dorsal root ganglia and trigeminal ganglia and also in vagal afferent neurons that innervate the lungs and gastrointestinal tract. Many TRPA1 agonists are reactive electrophilic compounds that form covalent adducts with TRPA1.
Shaw-Wen, Wu +4 more
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