Results 41 to 50 of about 23,681 (244)

TRPA1 expression and its functional activation in rodent cortex [PDF]

Open Biology, 2017
TRPA1 is a non-selective cation channel involved in pain sensation and neurogenic inflammation. Although TRPA1 is well established in a number of organs including the nervous system, its presence and function in the mammalian cortex remains unclear. Here,
Ehsan Kheradpezhouh, Julian M. C. Choy, Vincent R. Daria, Ehsan Arabzadeh   +3 more
doaj   +1 more source

On the G-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulation [PDF]

, 2013
The modulatory role of allosteric receptor-receptor interactions in the pain pathways of the Central Nervous System and the peripheral nociceptors has become of increasing interest.
Agnati, Luigi F, Borroto-Escuela, Dasiel O, Fuxe, Kjell, Rivera, Alicia, Romero-Fernandez, Wilber, Tarakanov, Alexander O, Van Craenenbroeck, Kathleen   +6 more
core   +3 more sources

TRPA1 mediates formalin-induced pain [PDF]

Proceedings of the National Academy of Sciences, 2007
The formalin model is widely used for evaluating the effects of analgesic compounds in laboratory animals. Injection of formalin into the hind paw induces a biphasic pain response; the first phase is thought to result from direct activation of primary afferent sensory neurons, whereas the second phase has been proposed to reflect the ...
Colleen R, McNamara, Josh, Mandel-Brehm, Diana M, Bautista, Jan, Siemens, Kari L, Deranian, Michael, Zhao, Neil J, Hayward, Jayhong A, Chong, David, Julius, Magdalene M, Moran, Christopher M, Fanger   +10 more
openaire   +2 more sources

Molecular Sensors and Modulators of Thermoreception [PDF]

, 2015
Peer ...
Zhang, Xuming
core   +1 more source

TRPA1: Acrolein meets its target [PDF]

Toxicology and Applied Pharmacology, 2017
Two papers in this issue of Toxicology and Applied Pharmacology reveal that the sensory irritant receptor, Transient Receptor Potential Ankyrin 1 (TRPA1), plays a key role in the morbidity and mortality caused by inhalation of acrolein, the major electrophile in smoke from fires, tobacco and in automobile exhaust (Conklin et al., 2016; Kurhanewicz et ...
Satyanarayana Achanta, Sven-Eric Jordt
openaire   +2 more sources

Identification of Natural Compound Carnosol as a Novel TRPA1 Receptor Agonist [PDF]

, 2014
The transient receptor potential ankyrin 1 (TRPA1) cation channel is one of the well-known targets for pain therapy. Herbal medicine is a rich source for new drugs and potentially useful therapeutic agents.
Li, Shiyou, Liu, Qing, Qiao, Yanjiang, Wang, Shifeng, Zhai, Chenxi, Zhang, Yanling, Zhang, Yuxin   +6 more
core   +3 more sources

Curcumin ameliorates oxaliplatin-induced allodynia response and melanocortin downregulation in the spinal cord

Research Results in Pharmacology
Introduction: Oxaliplatin is a platinum-based chemotherapy agent that often causes chemotherapy-induced peripheral neuropathy (CIPN). This effect limits the potential activity and decreases the cancer patient’s quality of life. Melanocortin and transient
Alma Nuril Aliya, Luke Wongso, Diah Ayu Wakita Trimanda , Risda Maulida, I Nengah Budi Sumartha, Samirah Samirah, Abdulloh Machin, Long Chiau Ming, Abdelhakim Bouyahya, Mahardian Rahmadi, Junaidi Khotib, Сhrismawan Ardianto   +11 more
doaj   +1 more source

Potency of irritation by benzylidenemalononitriles in humans correlates with TRPA1 ion channel activation [PDF]

Royal Society Open Science, 2015
We show that the physiological activity of solid aerosolized benzylidenemalononitriles (BMNs) including ‘tear gas’ (CS) in historic human volunteer trials correlates with activation of the human transient receptor potential ankyrin 1 ion channel (hTRPA1).
Christopher D. Lindsay, Christopher Green, Mike Bird, James T. A. Jones, James R. Riches, Katherine K. McKee, Mark S. Sandford, Debra A. Wakefield, Christopher M. Timperley   +8 more
doaj   +1 more source

Function and therapeutic potential of transient receptor potential ankyrin 1 in fibrosis

Frontiers in Pharmacology, 2022
The transient receptor potential (TRP) protein superfamily is a special group of cation channels expressed in different cell types and signaling pathways.
Yicheng Wei, Yicheng Wei, Yicheng Wei, Jialuo Cai, Jialuo Cai, Ruiqiu Zhu, Ruiqiu Zhu, Ke Xu, Ke Xu, Hongchang Li, Jianxin Li   +10 more
doaj   +1 more source

Annexin A2 Regulates TRPA1-Dependent Nociception [PDF]

The Journal of Neuroscience, 2014
The transient receptor potential A1 (TRPA1) channel is essential for vertebrate pain. Even though TRPA1 activation by ligands has been studied extensively, the molecular machinery regulating TRPA1 is only poorly understood. Using an unbiased proteomics-based approach we uncovered the physical association of Annexin A2 (AnxA2) with native TRPA1 in mouse
Luca Avenali, Pratibha Narayanan, Tom Rouwette, Ilaria Cervellini, Michael Sereda, David Gomez-Varela, Manuela Schmidt   +6 more
openaire   +5 more sources