Results 41 to 50 of about 12,428 (199)

Curcumin ameliorates oxaliplatin-induced allodynia response and melanocortin downregulation in the spinal cord

Research Results in Pharmacology
Introduction: Oxaliplatin is a platinum-based chemotherapy agent that often causes chemotherapy-induced peripheral neuropathy (CIPN). This effect limits the potential activity and decreases the cancer patient’s quality of life. Melanocortin and transient
Alma Nuril Aliya, Luke Wongso, Diah Ayu Wakita Trimanda , Risda Maulida, I Nengah Budi Sumartha, Samirah Samirah, Abdulloh Machin, Long Chiau Ming, Abdelhakim Bouyahya, Mahardian Rahmadi, Junaidi Khotib, Сhrismawan Ardianto   +11 more
doaj   +1 more source

Chilling injury mechanism in the immature oocytes of zebrafish (Danio rerio)

The Journal of Reproduction and Development
Immature zebrafish oocytes are sensitive to chilling, and their survival is markedly reduced by exposure to 0°C. In the present study, we investigated the involvement of cold-sensitive channels and lipid mediators in chilling injury in immature zebrafish ...
Yanuar ACHADRI, Shino SONODA, Saki OKUBO, Kazutsugu MATSUKAWA, Keisuke EDASHIGE   +4 more
doaj   +1 more source

Research Progress on TRPA1 in Diseases

The Journal of Membrane Biology, 2023
AbstractFor a long time, the physiological activity of TRP ion channels and the response to various stimuli have been the focus of attention, and the physiological functions mediated by ion channels have subtle links with the occurrence of various diseases. Our group has been engaged in the study of ion channels.
Li, Jiajing, Zhang, Hongfei, Du, Qian, Gu, Junyu, Wu, Jiangbo, Liu, Qi, Li, Zhuo, Zhang, Ting, Xu, Jingyu, Xie, Rui   +9 more
openaire   +2 more sources

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

TMEM100, a regulator of TRPV1-TRPA1 interaction, contributes to temporomandibular disorder pain

Frontiers in Molecular Neuroscience, 2023
There is an unmet need to identify new therapeutic targets for temporomandibular disorder (TMD) pain because current treatments are limited and unsatisfactory.
Peng Wang, Qiaojuan Zhang, Fabiana C. Dias, Abbie Suttle, Xinzhong Dong, Yong Chen, Yong Chen, Yong Chen   +7 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Transient Receptor Potential Channel A1 (TRPA1) Regulates Sulfur Mustard-Induced Expression of Heat Shock 70 kDa Protein 6 (HSPA6) In Vitro

Cells, 2018
The chemosensory transient receptor potential ankyrin 1 (TRPA1) ion channel perceives different sensory stimuli. It also interacts with reactive exogenous compounds including the chemical warfare agent sulfur mustard (SM).
Robin Lüling, Harald John, Thomas Gudermann, Horst Thiermann, Harald Mückter, Tanja Popp, Dirk Steinritz   +6 more
doaj   +1 more source

Inflammation—the role of TRPA1 channel

Frontiers in Physiology, 2023
Recently, increasing numbers of studies have demonstrated that transient receptor potential ankyrin 1 (TRPA1) can be used as a potential target for the treatment of inflammatory diseases. TRPA1 is expressed in both neuronal and non-neuronal cells and is involved in diverse physiological activities, such as stabilizing of cell membrane potential ...
Kaifang Yao, Baomin Dou, Yue Zhang, Zhihan Chen, Yanwei Li, Zezhi Fan, Yajing Ma, Simin Du, Jiangshan Wang, Zhifang Xu, Zhifang Xu, Zhifang Xu, Yangyang Liu, Yangyang Liu, Yangyang Liu, Xiaowei Lin, Xiaowei Lin, Xiaowei Lin, Shenjun Wang, Shenjun Wang, Shenjun Wang, Yi Guo, Yi Guo, Yi Guo   +23 more
openaire   +3 more sources

A Metal‐Phenolic Nanocluster Orchestrates Mito‐Ca2+ Metabolic Autonomy for Tumor Ca2+ Interference Therapy

Advanced Science, EarlyView.
Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie   +13 more
wiley   +1 more source

Polysulfide Evokes Acute Pain through the Activation of Nociceptive TRPA1 in Mouse Sensory Neurons

Molecular Pain, 2015
Background Hydrogen sulfide (H 2 S) is oxidized to polysulfide. Recent reports show that this sulfur compound modulates various biological functions. We have reported that H 2 S is involved in inflammatory pain in mice. On the other hand, little is known
Yukari Hatakeyama, Kenji Takahashi, Makoto Tominaga, Hideo Kimura, Toshio Ohta   +4 more
doaj   +1 more source