Results 31 to 40 of about 13,150 (209)
TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide. [PDF]
PLoS ONE, 2012 Hydrogen sulfide (H(2)S), which is produced endogenously from L-cysteine, is an irritant with pro-nociceptive actions. We have used measurements of intracellular calcium concentration, electrophysiology and behavioral measurements to show that the ...
David A Andersson +2 more
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Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels [PDF]
Proceedings of the National Academy of Sciences, 2008 Caffeine has various well-characterized pharmacological effects, but in mammals there are no known plasma membrane receptors or ion channels activated by caffeine. We observed that caffeine activates mouse transient receptor potential A1 (TRPA1) in heterologous expression systems by Ca i 2+
Katsuhiro, Nagatomo, Yoshihiro, Kubo
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Chilling injury mechanism in the immature oocytes of zebrafish (Danio rerio)
The Journal of Reproduction and DevelopmentImmature zebrafish oocytes are sensitive to chilling, and their survival is markedly reduced by exposure to 0°C. In the present study, we investigated the involvement of cold-sensitive channels and lipid mediators in chilling injury in immature zebrafish ...
Yanuar ACHADRI +4 more
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Warmth suppresses and desensitizes damage-sensing ion channel TRPA1
Molecular Pain, 2012 Background Acute or chronic tissue damage induces an inflammatory response accompanied by pain and alterations in local tissue temperature. Recent studies revealed that the transient receptor potential A1 (TRPA1) channel is activated by a wide variety of
Wang Sen +3 more
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Research Results in PharmacologyIntroduction: Oxaliplatin is a platinum-based chemotherapy agent that often causes chemotherapy-induced peripheral neuropathy (CIPN). This effect limits the potential activity and decreases the cancer patient’s quality of life. Melanocortin and transient
Alma Nuril Aliya +11 more
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An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2
Advanced Science, EarlyView.Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu +7 more
wiley +1 more source
Linkage of alternative exon assembly in Drosophila TrpA1 transcripts
Molecules and Cells: Drosophila TrpA1 (transient receptor potential ankyrin 1) transcripts are alternatively spliced at 2 distinct sites each with a choice of mutually exclusive exons.
Eun Jo Du +5 more
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Contribution of Drosophila TRPA1-expressing neurons to circadian locomotor activity patterns. [PDF]
PLoS ONE, 2013 In both vertebrates and invertebrates, Transient Receptor Potential (TRP) channels are expressed in sensory neurons and mediate environmental stimuli such as light, sound, temperature, and taste. Some of these channels, however, are expressed only in the
Youngseok Lee
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TRPA1: An asthma target with a zing [PDF]
Journal of Experimental Medicine, 2021 Asthma therapy has advanced remarkably; however, a significant number of patients respond poorly to current interventions. Balestrini et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201637) advance the concept that sensory nerves control inflammation in asthma, demonstrating that a novel inhibitor of TRPA1, a nerve receptor for irritants and ...
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BMC Research Notes, 2021 Objective Transient receptor potential ankyrin 1 (TRPA1) is an excitatory ion channel expressed on a subset of sensory neurons. TRPA1 is activated by a host of noxious stimuli including pollutants, irritants, oxidative stress and inflammation, and is ...
Parmvir K. Bahia, Thomas E. Taylor-Clark
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