Results 31 to 40 of about 12,878 (216)
Molecular Pain, 2007 Agonists of TRPA1 such as mustard oil and its key component AITC cause pain and neurogenic inflammation in humans and pain behavior in rodents. TRPA1 is activated by numerous reactive compounds making it a sensor for reactive compounds in the body ...
Immke David C +6 more
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Cells, 2014 Transient receptor potential (TRP) ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are implicated in modulation of cough and nociception. In vivo, TRPA1 and TRPV1 are often co-expressed in neurons and TRPA1V1 hetero-tetramer formation is noted in ...
Laura R. Sadofsky +10 more
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TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide. [PDF]
PLoS ONE, 2012 Hydrogen sulfide (H(2)S), which is produced endogenously from L-cysteine, is an irritant with pro-nociceptive actions. We have used measurements of intracellular calcium concentration, electrophysiology and behavioral measurements to show that the ...
David A Andersson +2 more
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Function and therapeutic potential of transient receptor potential ankyrin 1 in fibrosis
Frontiers in Pharmacology, 2022 The transient receptor potential (TRP) protein superfamily is a special group of cation channels expressed in different cell types and signaling pathways.
Yicheng Wei +10 more
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BMC Research Notes, 2021 Objective Transient receptor potential ankyrin 1 (TRPA1) is an excitatory ion channel expressed on a subset of sensory neurons. TRPA1 is activated by a host of noxious stimuli including pollutants, irritants, oxidative stress and inflammation, and is ...
Parmvir K. Bahia, Thomas E. Taylor-Clark
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Pharmaceuticals, 2021 Transient receptor potential ankyrin 1 (TRPA1), a nonselective cation channel, contributes to several (patho)physiological processes. Smell loss is an early sign in several neurodegenerative disorders, such as multiple sclerosis, Parkinson’s and ...
János Konkoly +9 more
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Contribution of TRPV1-TRPA1 Interaction to the Single Channel Properties of the TRPA1 Channel [PDF]
Journal of Biological Chemistry, 2010 Several lines of evidence suggest that TRPA1 and TRPV1 mutually control the transduction of inflammation-induced noxious stimuli in sensory neurons. It was recently shown that certain TRPA1 properties are modulated by TRPV1. However, direct interaction between TRPA1 and TRPV1 as well as regulation of TRPA1 intrinsic characteristics by the TRPV1 channel
Alexander, Staruschenko +2 more
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Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels [PDF]
Proceedings of the National Academy of Sciences, 2008 Caffeine has various well-characterized pharmacological effects, but in mammals there are no known plasma membrane receptors or ion channels activated by caffeine. We observed that caffeine activates mouse transient receptor potential A1 (TRPA1) in heterologous expression systems by Ca i 2+
Katsuhiro, Nagatomo, Yoshihiro, Kubo
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Research Results in PharmacologyIntroduction: Oxaliplatin is a platinum-based chemotherapy agent that often causes chemotherapy-induced peripheral neuropathy (CIPN). This effect limits the potential activity and decreases the cancer patient’s quality of life. Melanocortin and transient
Alma Nuril Aliya +11 more
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Chilling injury mechanism in the immature oocytes of zebrafish (Danio rerio)
The Journal of Reproduction and DevelopmentImmature zebrafish oocytes are sensitive to chilling, and their survival is markedly reduced by exposure to 0°C. In the present study, we investigated the involvement of cold-sensitive channels and lipid mediators in chilling injury in immature zebrafish ...
Yanuar ACHADRI +4 more
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