Results 31 to 40 of about 12,428 (199)
Frontiers in Pharmacology, 2020 Transient receptor potential ankyrin 1 (TRPA1) channel is an ion channel whose gating is controlled by agonists, such as allyl isothiocyanate (AITC), and temperature.
Megumi Yoshida +4 more
doaj +1 more source
TRPA1 Contributes to Cold Hypersensitivity [PDF]
The Journal of Neuroscience, 2010 TRPA1 is a nonselective cation channel expressed by nociceptors. Although it is widely accepted that TRPA1 serves as a broad irritancy receptor for a variety of reactive chemicals, its role in cold sensation remains controversial. Here, we demonstrate that mild cooling markedly increases agonist-evoked rat TRPA1 currents.
Donato, del Camino +17 more
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TRPA1: An asthma target with a zing [PDF]
Journal of Experimental Medicine, 2021 Asthma therapy has advanced remarkably; however, a significant number of patients respond poorly to current interventions. Balestrini et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201637) advance the concept that sensory nerves control inflammation in asthma, demonstrating that a novel inhibitor of TRPA1, a nerve receptor for irritants and ...
openaire +2 more sources
ROS/TRPA1/CGRP signaling mediates cortical spreading depression
The Journal of Headache and Pain, 2019 Objectives The transient receptor potential ankyrin A 1 (TRPA1) channel and calcitonin gene-related peptide (CGRP) are targets for migraine prophylaxis.
Liwen Jiang +3 more
doaj +1 more source
Molecular Pain, 2007 Agonists of TRPA1 such as mustard oil and its key component AITC cause pain and neurogenic inflammation in humans and pain behavior in rodents. TRPA1 is activated by numerous reactive compounds making it a sensor for reactive compounds in the body ...
Immke David C +6 more
doaj +1 more source
BMC Research Notes, 2021 Objective Transient receptor potential ankyrin 1 (TRPA1) is an excitatory ion channel expressed on a subset of sensory neurons. TRPA1 is activated by a host of noxious stimuli including pollutants, irritants, oxidative stress and inflammation, and is ...
Parmvir K. Bahia, Thomas E. Taylor-Clark
doaj +1 more source
Function and therapeutic potential of transient receptor potential ankyrin 1 in fibrosis
Frontiers in Pharmacology, 2022 The transient receptor potential (TRP) protein superfamily is a special group of cation channels expressed in different cell types and signaling pathways.
Yicheng Wei +10 more
doaj +1 more source
TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide. [PDF]
PLoS ONE, 2012 Hydrogen sulfide (H(2)S), which is produced endogenously from L-cysteine, is an irritant with pro-nociceptive actions. We have used measurements of intracellular calcium concentration, electrophysiology and behavioral measurements to show that the ...
David A Andersson +2 more
doaj +1 more source
Pharmaceuticals, 2021 Transient receptor potential ankyrin 1 (TRPA1), a nonselective cation channel, contributes to several (patho)physiological processes. Smell loss is an early sign in several neurodegenerative disorders, such as multiple sclerosis, Parkinson’s and ...
János Konkoly +9 more
doaj +1 more source
TRPA1 as Target in Myocardial Infarction
International Journal of Molecular Sciences, 2023 Transient receptor potential cation channel subfamily A member 1 (TRPA1), an ion channel primarily expressed on sensory neurons, can be activated by substances occurring during myocardial infarction. Aims were to investigate whether activation, inhibition, or absence of TRPA1 affects infarcts and to explore underlying mechanisms.
Clara Hoebart +6 more
openaire +2 more sources