Results 1 to 10 of about 6,074 (135)

The TRPA1 cation channel is upregulated by cigarette smoke in mouse and human macrophages modulating lung inflammation [PDF]

Scientific Reports
Cigarette smoke (CS) is a well-known source of several inflammatory, cytotoxic and genotoxic compounds that cause chronic lung diseases. The transient receptor potential ankyrin 1 (TRPA1), a smoking-responsive, non-selective cation channel, is expressed ...
Anita Steib, Katalin Rozmer, Éva Szőke, József Kun, Nelli Farkas, Diána Feller, Judit Pongrácz, Krisztina Pohóczky, Zsuzsanna Helyes   +8 more
doaj   +3 more sources

TRPA1 Regulates Fibrosis-Associated Transcriptional Pathways in Human Lung Epithelial Cells. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Transient receptor potential ankyrin 1 (TRPA1) is a cation channel originally identified in lung fibroblasts and extensively studied in sensory neurons, where it is associated with pain and neurogenic inflammation. We and others have recently shown that TRPA1 is also expressed in lung epithelial cells and that its expression is regulated by ...
Halonen L, Luostarinen S, Valjus I, Vistbacka J, Pemmari A, Moilanen E.   +5 more
europepmc   +2 more sources

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin. [PDF]

J Physiol
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Alemayhu AM, Paulsen CE.
europepmc   +2 more sources

Allyl isothiocyanate (AITC) activates nonselective cation currents in human cardiac fibroblasts: possible involvement of TRPA1

Heliyon, 2021
The effects of allyl isothiocyanate (AITC), transient receptor potential ankyrin 1 (TRPA1) agonist, on cultured human cardiac fibroblasts were examined by measuring intracellular Ca2+ concentration [Ca2+]i and whole-cell voltage clamp techniques.
Gaku Oguri, Toshiaki Nakajima, Hironobu Kikuchi, Shotaro Obi, Fumitaka Nakamura, Issei Komuro   +5 more
doaj   +3 more sources

TRPA1 as a Key Regulator of Keratinocyte Homeostasis and Inflammation in Human Skin [PDF]

Cells
The Transient Receptor Potential Ankyrin 1 (TRPA1) channel is a non-selective cation channel activated by a range of physical and chemical stimuli. While primarily studied in neuronal tissues, TRPA1 is also expressed in human keratinocytes, where its ...
Caterina Cattani, Claudia Scarponi, Martina Morelli, Kilian Eyerich, Stefanie Eyerich, Christian Napoli, Stefania Madonna, Cristina Albanesi, Andrea Cavani, Fernanda Scopelliti   +9 more
doaj   +2 more sources

A TREK-1/AQP4/TRPA1/BDNF Signaling Axis Is Associated With Astrocytic Volume Transients, Synaptic Plasticity, and Spatial Memory. [PDF]

Glia
Astrocytic TREK‐1‐dependent volume transients contribute to hippocampal synaptic plasticity and memory formation. TRPA1‐mediated astrocytic calcium signaling is required for long‐term potentiation, while astrocytic BDNF is necessary and sufficient to support sustained synaptic plasticity.
Drew VJ, Woo J, Lee JM, Koh W, Won J, Lee JH, Lee CJ.   +6 more
europepmc   +2 more sources

TRPA1 Expressed by Hepatocytes and Liver Macrophages Does Not Mediate Inflammatory Infiltration and Steatosis in a Mouse Model of Chronic Alcohol-Induced Liver Injury [PDF]

Cells
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel, and its activator, the alcohol breakdown product acetaldehyde, plays a key role in the pathomechanism of alcoholic liver disease (ALD).
Dorottya Luca Fehér, Ammar Al-Omari, Zoltán Sándor, Dániel Hegedüs, Balázs Gaszner, Veronika Szombati, András Fincsur, Viktória Kormos   +7 more
doaj   +2 more sources

Lithium prevents the neurotoxic effects of paclitaxel mediated through TRPA1 channels [PDF]

Molecular Pain
Paclitaxel (PTX) is a drug commonly used in cancer chemotherapy despite its neurotoxicity. TRPA1 channels are essential mediators of sensory transduction and nociception. These cation channels are linked to PTX-induced neurotoxicity, which Li + prevents.
Julio C Sánchez, Aníbal Valencia-Vásquez, Juan C Olaya, Alexander Alemán, Jenifer Guerrero, Martín Torres, Luís F Martínez, Laura V Muñoz   +7 more
doaj   +2 more sources

Chronic alcohol consumption downregulates TRPA1 ion channel and the main peptidergic messengers of the Edinger-Westphal nucleus [PDF]

Scientific Reports
The urocortin 1 (UCN1) and cocaine- and amphetamine-regulated transcript (CART) co-expressing neurons of the centrally projecting Edinger-Westphal nucleus (EWcp), regulate the function of reward- and addiction-related brain areas.
Ammar Al-Omari, Izabella Török, Balázs Zoltán Zsidó, Csaba Hetényi, Erika Pintér, Zoltán Sándor, Gergely Berta, Péter Szocsics, Péter Gombás, Tünde Biró-Sütő, Balázs Gaszner, Viktória Kormos   +11 more
doaj   +2 more sources

Function and therapeutic potential of transient receptor potential ankyrin 1 in fibrosis

Frontiers in Pharmacology, 2022
The transient receptor potential (TRP) protein superfamily is a special group of cation channels expressed in different cell types and signaling pathways.
Yicheng Wei, Yicheng Wei, Yicheng Wei, Jialuo Cai, Jialuo Cai, Ruiqiu Zhu, Ruiqiu Zhu, Ke Xu, Ke Xu, Hongchang Li, Jianxin Li   +10 more
doaj   +1 more source