Results 1 to 10 of about 5,960 (158)

The TRPA1 cation channel is upregulated by cigarette smoke in mouse and human macrophages modulating lung inflammation [PDF]

Scientific Reports
Cigarette smoke (CS) is a well-known source of several inflammatory, cytotoxic and genotoxic compounds that cause chronic lung diseases. The transient receptor potential ankyrin 1 (TRPA1), a smoking-responsive, non-selective cation channel, is expressed ...
Anita Steib, Katalin Rozmer, Éva Szőke, József Kun, Nelli Farkas, Diána Feller, Judit Pongrácz, Krisztina Pohóczky, Zsuzsanna Helyes   +8 more
doaj   +5 more sources

TRPA1 as a Key Regulator of Keratinocyte Homeostasis and Inflammation in Human Skin [PDF]

Cells
The Transient Receptor Potential Ankyrin 1 (TRPA1) channel is a non-selective cation channel activated by a range of physical and chemical stimuli. While primarily studied in neuronal tissues, TRPA1 is also expressed in human keratinocytes, where its ...
Caterina Cattani, Claudia Scarponi, Martina Morelli, Kilian Eyerich, Stefanie Eyerich, Christian Napoli, Stefania Madonna, Cristina Albanesi, Andrea Cavani, Fernanda Scopelliti   +9 more
doaj   +2 more sources

The TRPA1 Channel in the Cardiovascular System: Promising Features and Challenges

Frontiers in Pharmacology, 2019
The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable nonselective cation channel in the plasma membrane that belongs to the transient receptor potential (TRP) channel superfamily.
Zhen Wang, Zhen Wang, Zhen Wang, Di Ye, Di Ye, Di Ye, Jing Ye, Jing Ye, Jing Ye, Menglong Wang, Menglong Wang, Menglong Wang, Jianfang Liu, Jianfang Liu, Jianfang Liu, Huimin Jiang, Huimin Jiang, Huimin Jiang, Yao Xu, Yao Xu, Yao Xu, Jishou Zhang, Jiangbin Chen, Jun Wan, Jun Wan, Jun Wan   +25 more
doaj   +3 more sources

Allyl isothiocyanate (AITC) activates nonselective cation currents in human cardiac fibroblasts: possible involvement of TRPA1

Heliyon, 2021
The effects of allyl isothiocyanate (AITC), transient receptor potential ankyrin 1 (TRPA1) agonist, on cultured human cardiac fibroblasts were examined by measuring intracellular Ca2+ concentration [Ca2+]i and whole-cell voltage clamp techniques.
Gaku Oguri, Toshiaki Nakajima, Hironobu Kikuchi, Shotaro Obi, Fumitaka Nakamura, Issei Komuro   +5 more
doaj   +3 more sources

The cation channel TRPA1 tunes mosquito thermotaxis to host temperatures

eLife, 2015
While most animals thermotax only to regulate their temperature, female mosquitoes are attracted to human body heat during pursuit of a blood meal.
Román A Corfas, Leslie B Vosshall
doaj   +3 more sources

Lithium prevents the neurotoxic effects of paclitaxel mediated through TRPA1 channels [PDF]

Molecular Pain
Paclitaxel (PTX) is a drug commonly used in cancer chemotherapy despite its neurotoxicity. TRPA1 channels are essential mediators of sensory transduction and nociception. These cation channels are linked to PTX-induced neurotoxicity, which Li + prevents.
Julio C Sánchez, Aníbal Valencia-Vásquez, Juan C Olaya, Alexander Alemán, Jenifer Guerrero, Martín Torres, Luís F Martínez, Laura V Muñoz   +7 more
doaj   +2 more sources

Chronic alcohol consumption downregulates TRPA1 ion channel and the main peptidergic messengers of the Edinger-Westphal nucleus [PDF]

Scientific Reports
The urocortin 1 (UCN1) and cocaine- and amphetamine-regulated transcript (CART) co-expressing neurons of the centrally projecting Edinger-Westphal nucleus (EWcp), regulate the function of reward- and addiction-related brain areas.
Ammar Al-Omari, Izabella Török, Balázs Zoltán Zsidó, Csaba Hetényi, Erika Pintér, Zoltán Sándor, Gergely Berta, Péter Szocsics, Péter Gombás, Tünde Biró-Sütő, Balázs Gaszner, Viktória Kormos   +11 more
doaj   +2 more sources

TRPA1 Expressed by Hepatocytes and Liver Macrophages Does Not Mediate Inflammatory Infiltration and Steatosis in a Mouse Model of Chronic Alcohol-Induced Liver Injury [PDF]

Cells
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel, and its activator, the alcohol breakdown product acetaldehyde, plays a key role in the pathomechanism of alcoholic liver disease (ALD).
Dorottya Luca Fehér, Ammar Al-Omari, Zoltán Sándor, Dániel Hegedüs, Balázs Gaszner, Veronika Szombati, András Fincsur, Viktória Kormos   +7 more
doaj   +2 more sources

Exploring the epigenetic modifications of the RONS-TRPA1-CGRP axis in migraine pathophysiology [PDF]

The Journal of Headache and Pain
Background Epigenetic studies in migraine provided results on the occurrence or lack of epigenetic modifications of genes whose products are important in migraine pathogenesis. However, these studies focus on single genes without analyzing how epigenetic
Michal Fila, Elzbieta Pawlowska, Jan Krekora, Maria Mitus-Kenig, Janusz Blasiak   +4 more
doaj   +2 more sources

The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel. [PDF]

Br J Pharmacol, 2017
Background and PurposeThe mechanism of the anti‐migraine action of extracts of butterbur [Petasites hybridus(L.) Gaertn.] is unknown. Here, we investigated the ability of isopetasin, a major constituent of these extracts, to specifically target TRPA1 channel and to affect functional responses relevant to migraine.Experimental ApproachSingle‐cell ...
Benemei S, De Logu F, Li Puma S, Marone IM, Coppi E, Ugolini F, Liedtke W, Pollastro F, Appendino G, Geppetti P, Materazzi S, Nassini R.   +11 more
europepmc   +4 more sources